Skeletal myopathy in transgenic mice carrying human prototype c-Ha-ras gene

Toxicologic Pathology

Volumn 30, Issue 4, 2002, Pages 501-506

  Tsuchiya, Takayuki ^a   Kobayashi, Kiyoshi ^a   Sakairi, Tetsuya ^a   Goto, Kazuhiro ^a   Okada, Miyoko ^a   Sano, Fumiko ^a   Sugimoto, Jiro ^a   Morohashi, Tetsuo ^a   Usui, Toshimi ^b   Mutai, Mamoru ^a  

^a Toxicology Laboratory   (Japan)

^b CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

Author keywords

Histopathology; Muscular dystrophy; Ras gene; rasH2 mouse; Skeletal muscle; Spontaneous

Indexed keywords

C HA RAS PROTEIN; GENE PRODUCT; UNCLASSIFIED DRUG; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; GENE; GENE IDENTIFICATION; HISTOPATHOLOGY; HYALINE DEGENERATION; INFLAMMATION; MALE; MOUSE; MUSCLE CELL; MUSCULAR DYSTROPHY; MYOPATHY; NONHUMAN; ONCOGENE C H RAS; PATHOGENESIS; PECTORALIS MAJOR MUSCLE; PERIPHERAL NERVE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TRANSGENIC MOUSE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; HUMAN; ONCOGENE RAS; PATHOLOGY; PHYSIOLOGY;

ANIMAL; FEMALE; GENES, RAS; HUMAN; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; RNA, MESSENGER; ANIMALS; HUMANS;

ANIMALIA; MUS MUSCULUS;

EID: 0036628962     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230290105677     Document Type: Article

References (35)

1. Electron microscopic and autoradiographic characterization of hind limb muscle regeneration in the mdx mouse
2. Ras oncogenes in human cancer: A review
3. X chromosome-linked muscular dystrophy (mdx) in the mouse
4. Feline muscular dystrophy with dystrophin deficiency
5. A point mutation in the last intron responsible for increased expression and transforming activity of the c-Ha-ras oncogene
6. The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs
7. The mdx mouse skeletal muscle myopathy: I. A histological, morphometric and biochemical investigation
8. The muscular dystrophies
9. Cardiac involvement in primary myopathies
10. Dystrophin: The protein product of Duchenne muscular dystrophy locus
11. Dystrophin abnormalities in Duchenne/Becker muscular dystrophy
12. Neuromuscular disorders: Gene location
13. Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene
14. Lack of modifying effects of eugenol on development of lung proliferative lesions induced by urethane in transgenic mice carrying the human prototype c-Ha-ras gene
15. c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be associated from cell transformation
16. Severe cardiomyopathy in mice lacking dystropin and MyoD
17. Muscular dystrophy in the mouse caused by an allele at the dy-locus
18. Dystrophia muscularis: A hereditary primary myopathy in the house mouse
19. c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation
20. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcingenicity study of vinyl carbamate and ras gene analyses of the induced tumors
21. Utility of transgenic mice carrying human prototype c-Ha-ras gene for alternative carcinogenicity testing of chemicals - Negative results with methapyrilene hydrochloride
22. The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation
23. A role for RaIGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis
24. The international life sciences institute’s role in the evaluation of alternative methodologies for the assessment of carcinogenic risk
25. The molecular regulation of myogenesis
26. Most tumors in transgenic mice with human c-Ha-ras-gene contained somatically activated trangene
27. X chromosome-linked muscular dystrophy (mdx) of the skeletal muscle, mouse
28. Twenty-six-week carcinogenicity study of sulfamethoxazole in CB6FI-Tg rasH2 mice
29. The mutant mdx: Inherited myopathy in the mouse. Morphological studies of nerves, muscles and end-plates
30. Biological characterization and oncogene expression in human colorectal carcinoma cell lines
31. Elevation of the level of thiobarbituric acid-reactive products in hindleg skeletal muscle of dystrophic mice, but non-elevation in tongue muscle
32. Oncogenic Ras-induced secretion of a novel inhibitor of skeletal myoblast
33. Postnatal growth and differentiation of muscle fibers in the mouse. II. A histochemical and morphometric investigation of dystrophic muscle
34. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene
35. Validation of transgenic mice carrying the human prototype c-Ha-ras-gene as a bioassay model for rapid carcinogenicity testing