메뉴 건너뛰기




Volumn 13, Issue 3, 2000, Pages 179-188

Utility of Transgenic Mice Carrying Human Prototype c-Ha-im Gene for Alternative Carcinogenicity Testing of Chemicals - Negative Results with Methapyrilene Hydrochloride

Author keywords

Human c Ha ras gene; Methapyrilene hydrochloride; RasH2 mouse; Short term carcinogenicity test

Indexed keywords


EID: 0001313710     PISSN: 09149198     EISSN: 09149198     Source Type: Journal    
DOI: 10.1293/tox.13.179     Document Type: Article
Times cited : (5)

References (37)
  • 1
    • 0028902169 scopus 로고
    • Marketed human pharmaceuticals reported to be tumorigenic in rodents
    • Davies TS and Monro A. Marketed human pharmaceuticals reported to be tumorigenic in rodents. J Am Coll Toxicol 1995; 14: 90-107.
    • (1995) J Am Coll Toxicol , vol.14 , pp. 90-107
    • Davies, T.S.1    Monro, A.2
  • 2
    • 0028892461 scopus 로고
    • Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models
    • Tennant RW, French JE, and Spalding JW. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ Health Perspect 1995; 103: 942-950.
    • (1995) Environ Health Perspect , vol.103 , pp. 942-950
    • Tennant, R.W.1    French, J.E.2    Spalding, J.W.3
  • 3
    • 0028798677 scopus 로고
    • Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM transgenic mice
    • Storer RD, Cartwright ME, Cook WO, Soper KA, and Nichols WW. Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM transgenic mice. Carcinogenesis 1995 ; 16: 285-293.
    • (1995) Carcinogenesis , vol.16 , pp. 285-293
    • Storer, R.D.1    Cartwright, M.E.2    Cook, W.O.3    Soper, K.A.4    Nichols, W.W.5
  • 6
    • 0031871858 scopus 로고    scopus 로고
    • The international Life Sciences Institute's role in the evaluation of alternative methodologies for the assessment of carcinogenic risk
    • Robinson D. The international Life Sciences Institute's role in the evaluation of alternative methodologies for the assessment of carcinogenic risk. Toxicol Pathol 1998 ; 26: 474-475.
    • (1998) Toxicol Pathol , vol.26 , pp. 474-475
    • Robinson, D.1
  • 8
    • 0031854359 scopus 로고    scopus 로고
    • Pathological Features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies
    • Mitsumori K, Koizumi H, Nomura T, and Yamamoto S. Pathological Features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies. Toxicol Pathol 1998; 26: 520-531.
    • (1998) Toxicol Pathol , vol.26 , pp. 520-531
    • Mitsumori, K.1    Koizumi, H.2    Nomura, T.3    Yamamoto, S.4
  • 10
    • 0019307495 scopus 로고
    • Liver tumors induced in rats by oral administration of the antihistamic methapyrilene hydrochloride
    • Lijinsky W, Reuber MD, and Blackwell BN. Liver tumors induced in rats by oral administration of the antihistamic methapyrilene hydrochloride. Science 1980; 209: 817-819.
    • (1980) Science , vol.209 , pp. 817-819
    • Lijinsky, W.1    Reuber, M.D.2    Blackwell, B.N.3
  • 11
    • 0021068561 scopus 로고
    • Failure of methapyrilene to induce tumors in hamsters or guinea pigs
    • Lijinsky W, Knutsen G, and Reuber MD. Failure of methapyrilene to induce tumors in hamsters or guinea pigs. J Tox Environ Health 1983 ; 12: 653-657.
    • (1983) J Tox Environ Health , vol.12 , pp. 653-657
    • Lijinsky, W.1    Knutsen, G.2    Reuber, M.D.3
  • 12
    • 0020363739 scopus 로고
    • The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbitalinduced sleeping time in rats and mice
    • Brennan LM and Creasia DA. The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbitalinduced sleeping time in rats and mice. Toxicol Appl Pharmacol 1982; 66: 252-258.
    • (1982) Toxicol Appl Pharmacol , vol.66 , pp. 252-258
    • Brennan, L.M.1    Creasia, D.A.2
  • 13
    • 0023175454 scopus 로고
    • Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene
    • Mirsalis JC. Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene. Mutat Res 1987; 185: 309-317.
    • (1987) Mutat Res , vol.185 , pp. 309-317
    • Mirsalis, J.C.1
  • 16
    • 0023732831 scopus 로고
    • The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats
    • Casciano DA, Shaddock JG, and Talaska G. The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats. Mutat Res 1988 ; 208 : 129-135.
    • (1988) Mutat Res , vol.208 , pp. 129-135
    • Casciano, D.A.1    Shaddock, J.G.2    Talaska, G.3
  • 17
    • 0023796193 scopus 로고
    • Lack of binding of methapyrilene and similar antihistamines to rat liver DNA examined by 32P postlabeling
    • Lijinsky W and Yamashita K. Lack of binding of methapyrilene and similar antihistamines to rat liver DNA examined by 32P postlabeling. Cancer Res 1988 ; 48 : 6475-6477.
    • (1988) Cancer Res , vol.48 , pp. 6475-6477
    • Lijinsky, W.1    Yamashita, K.2
  • 18
    • 0020459516 scopus 로고
    • Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo
    • lype PT, Ray-Chaudhuri R, Lijinsky W, and Kelley SP. Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo. Cancer Res 1982; 42: 4614-4618.
    • (1982) Cancer Res , vol.42 , pp. 4614-4618
    • Lype, P.T.1    Ray-Chaudhuri, R.2    Lijinsky, W.3    Kelley, S.P.4
  • 19
    • 0021324775 scopus 로고
    • Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthineguanine phosphoribosyl transferase mutational assay
    • Casciano DA and Schol HM. Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthineguanine phosphoribosyl transferase mutational assay. Cancer Lett 1984; 21: 337-341.
    • (1984) Cancer Lett , vol.21 , pp. 337-341
    • Casciano, D.A.1    Schol, H.M.2
  • 20
    • 0023943565 scopus 로고
    • Examination of genotoxicity, toxicity, and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene
    • Steinmetz KL, Tyson CK, Meierhenry EF, Spalding JW, and Mirsalis JC. Examination of genotoxicity, toxicity, and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. Carcinogenesis 1988; 9: 959-963.
    • (1988) Carcinogenesis , vol.9 , pp. 959-963
    • Steinmetz, K.L.1    Tyson, C.K.2    Meierhenry, E.F.3    Spalding, J.W.4    Mirsalis, J.C.5
  • 23
    • 0025769580 scopus 로고
    • DNA methylation and oncogene expression in methapyrileneinduced rat liver tumors and in treated hepatocytes in culture
    • Harnandez L, Petropoulos CJ, Hughes SH, and Lijinsky W. DNA methylation and oncogene expression in methapyrileneinduced rat liver tumors and in treated hepatocytes in culture. Mol Carcinogenesis 1991 ; 4: 203-209.
    • (1991) Mol Carcinogenesis , vol.4 , pp. 203-209
    • Harnandez, L.1    Petropoulos, C.J.2    Hughes, S.H.3    Lijinsky, W.4
  • 24
    • 0021339705 scopus 로고
    • A sequential study of methapyrilene hydrochloride-induced liver Carcinogenesis in male F344 rats
    • Ohshima M, Ward JM, Brennan LM, and Creasia DA. A sequential study of methapyrilene hydrochloride-induced liver Carcinogenesis in male F344 rats. JNCI 1984; 72: 759-768.
    • (1984) JNCI , vol.72 , pp. 759-768
    • Ohshima, M.1    Ward, J.M.2    Brennan, L.M.3    Creasia, D.A.4
  • 25
    • 0021349181 scopus 로고
    • Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats
    • Lijinsky W. Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats. Fd Chem Toxic 1984 ; 22: 27-30.
    • (1984) Fd Chem Toxic , vol.22 , pp. 27-30
    • Lijinsky, W.1
  • 26
    • 0024438033 scopus 로고
    • Effect of the antihistamine, methapyrilene, as an initiator of hepatocarcinogenesis in female rats
    • Glauert HP and Pitot HC. Effect of the antihistamine, methapyrilene, as an initiator of hepatocarcinogenesis in female rats. Cancer Lett 1989; 46: 189-194.
    • (1989) Cancer Lett , vol.46 , pp. 189-194
    • Glauert, H.P.1    Pitot, H.C.2
  • 27
    • 0020644049 scopus 로고
    • An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide
    • Furuya K, Mori H, and Williams GM. An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide. Toxicol Appl Pharmacol 1983 ; 70 : 49-56.
    • (1983) Toxicol Appl Pharmacol , vol.70 , pp. 49-56
    • Furuya, K.1    Mori, H.2    Williams, G.M.3
  • 28
    • 0026659134 scopus 로고
    • The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses
    • Lijinsky W, Kovatch RM, and Thomas BJ. The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses. Carcinogenesis 1992 ; 13 : 1293-1297.
    • (1992) Carcinogenesis , vol.13 , pp. 1293-1297
    • Lijinsky, W.1    Kovatch, R.M.2    Thomas, B.J.3
  • 30
    • 0027103978 scopus 로고
    • Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure
    • Richardson FC, Copple DM, and Eacho PI. Effects of methapyrilene on DNA synthesis in mice and rats following continuous dietary exposure. Carcinogenesis 1992 ; 13 : 2453-2457.
    • (1992) Carcinogenesis , vol.13 , pp. 2453-2457
    • Richardson, F.C.1    Copple, D.M.2    Eacho, P.I.3
  • 31
    • 0028939149 scopus 로고
    • The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study
    • Cunningham ML, Pippin LL, Anderson NL, and Wenk ML. The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. Toxicol Appl Pharmacol 1995; 131: 216-223.
    • (1995) Toxicol Appl Pharmacol , vol.131 , pp. 216-223
    • Cunningham, M.L.1    Pippin, L.L.2    Anderson, N.L.3    Wenk, M.L.4
  • 32
    • 0019792469 scopus 로고
    • Morphology of early changes in liver Carcinogenesis induced by methapyrilene
    • Reznik-Schuller HM and Lijinsky W. Morphology of early changes in liver Carcinogenesis induced by methapyrilene. Arch Toxicol 1981; 49: 79-83.
    • (1981) Arch Toxicol , vol.49 , pp. 79-83
    • Reznik-Schuller, H.M.1    Lijinsky, W.2
  • 33
    • 0022271606 scopus 로고
    • Methapyrilene induces membrane lipid peroxidation of rat liver cells
    • Perera MIR, Katyal SL, and Shinozuka H. Methapyrilene induces membrane lipid peroxidation of rat liver cells. Carcinogenesis 1985; 6: 925-927.
    • (1985) Carcinogenesis , vol.6 , pp. 925-927
    • Perera, M.I.R.1    Katyal, S.L.2    Shinozuka, H.3
  • 34
    • 0030250237 scopus 로고    scopus 로고
    • Role of increased DNA replication in the carcinogenic risk of nonmutagenic chemical carcinogens
    • Cunningham ML. Role of increased DNA replication in the carcinogenic risk of nonmutagenic chemical carcinogens. Mutat Res 1996; 365: 59-69.
    • (1996) Mutat Res , vol.365 , pp. 59-69
    • Cunningham, M.L.1
  • 36
    • 0025184982 scopus 로고
    • Species differences in the metabolism and macromolecular binding of methapyrilene: A comparison of rat, mouse and hamster
    • Lampe MA and Kammerer RC. Species differences in the metabolism and macromolecular binding of methapyrilene : a comparison of rat, mouse and hamster. Xenobiotica 1990; 20: 1269-1280.
    • (1990) Xenobiotica , vol.20 , pp. 1269-1280
    • Lampe, M.A.1    Kammerer, R.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.