Potential alternatives to COX 2 inhibitors

British Medical Journal

Volumn 324, Issue 7349, 2002, Pages 1289-1290

  Skelly, M M ^a   Hawkey, C J ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; LEUKOTRIENE; LICOFELONE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

ARTHRITIS; DRUG EFFICACY; DRUG SAFETY; EDITORIAL; ENDOSCOPY; HUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROPHYLAXIS; STOMACH MUCOSA; STOMACH ULCER;

EID: 0036607705     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.324.7349.1289     Document Type: Editorial

References (12)

1. Are selective COX-2 inhibitors superior to traditional NSAIDs?
2. NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis
3. Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs
4. Redox-inhibitors: Discovery and development of ML3000
5. Gastrointestinal safety of AZD 3582: A new chemical entity with a novel multi-pathway mechanism of action
6. Licofelone (ML 3000) an inhibitor of COX-1, COX-2 and 5-LO is associated with less gastric damage than naproxen and is similar to placebo in man
7. A dual cyclo- and lipo-oxygenase inhibitor, ML3000 spares gastric mucosa in aspirin-treated rats
8. In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis
9. ML3000, recent clinical trials: A broader view of inflammatory processes
10. The effects of ML 3000 on antigen-induced responses in sheep
11. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee
12. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: A randomized trial