Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: Design of stable lipoxin B4 analogs with increased biologic activity

FASEB Journal

Volumn 12, Issue 6, 1998, Pages 487-494

  Maddox, Jane F ^a   Colgan, Sean P ^a   Clish, Clary B ^a   Petasis, Nicos A ^b   Fokin, Valery V ^b   Serhan, Charles N ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Eicosanoids; Inflammation; Leukocytes; Lipid mediators

Indexed keywords

15 EPILIPOXIN B4 METHYL ESTER; 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; 5,14,15 TRIHYDROXY 5 METHYL 6,8,12,10 ICOSATETRAENOIC ACID METHYL ESTER; ICOSANOID; LIPOXIN B; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; HYDROXYICOSATETRAENOIC ACID; LIPOXIN;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; LEUKOCYTE MOTILITY; MONOLAYER CULTURE; PRIORITY JOURNAL; CELL ADHESION; CELL CULTURE; CELL MOTION; CHEMISTRY; CYTOLOGY; DRUG DESIGN; DRUG EFFECT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCYTE; NEUTROPHIL; PHYSIOLOGY;

CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; DRUG DESIGN; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; LIPOXINS; MASS SPECTROMETRY; MONOCYTES; NEUTROPHILS;

EID: 0032037672     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.6.487     Document Type: Article

References (27)

1. Yamamoto, S., Suzuki, H., and Ueda, N. (1997) Arachidonate 12-lipoxygenases. Prog. Lipid Res. 36, 23-41
2. Samuelsson, B., Dahlen, S. E., Lindgren, J. Å., Rouzer, C. A., and Serhan, C. N. (1987) Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237, 1171-1176
3. Clària, J., and Serhan, C. N. (1995) Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc. Natl. Acad. Sci. USA 92, 9475-9479
4. Serhan, C. N., Haeggstrom, J. Z., and Leslie, C. C. (1996) Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J. 10, 1147-1158
5. Chavis, C., Vachier, I., Chanez, P., Bousquet, J., and Godard, P. (1996) 5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors, J. Exp. Med. 183, 1633-1643
6. Thomas, E., Leroux, J. L., Blotman, F., and Chavis, C. (1995) Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis. Inflamm. Res. 44, 121-124
7. Popov, G. K., Nekrasov, A. S., Khshivo, A. L., Pochinskii, A. G., and Lankin, V. Z. (1989) Effect of lipoxin B on colony-forming capacity of human peripheral blood mononuclear cells in diffusion chambers. Biull. Eksp. Biol. Med. 107, 80-83
8. 4 on signal transduction events in Friend erythroleukemia cells. Proc. Soc. Exp. Biol. Med. 201, 169-173
9. 2, lipoxins and leukotrienes on sleep and brain temperature of rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids 51, 87-93
10. 4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by de hydrogenation and reduction. J. Exp. Med. 183, 137-146
11. Stenke, L., Mansour, M., Edenius, C., Reizenstein, P., and Lindgren, J. Å. (1991) Formation and proliferative effects of lipoxins in human bone marrow. Biochem. Biophys. Res. Commun. 180, 255-261
12. 4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J. Immunol. 156, 2264-2272
13. Serhan, C. N. (1997) Lipoxins and novel aspirin-triggered 15-epi-lipoxins: a jungle of cell-cell interactions or a therapeutic opportunity? Prostaglandins 53, 107-137
14. 4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry 34, 14609-14615
15. 4 receptor. J. Biol. Chem. 272, 6972-6978
16. 4 stable analogues are potent inhibitors of acute inflammation: Evidence for anti-inflammatory receptors. J. Exp. Med. 185, 1693-1704
17. Braithwaite, S. S., and Jarabak, J. (1975) Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization. J. Biol. Chem. 250, 2315-2318
18. Böyum, A. (1968) Isolation of mononuclear cells and granules cytes from human blood. Scand. J. Clin. Lab. Invest. 21 (Suppl. 97), 77-89
19. Parkos, C. A., Delp, C., Arnaout, M. A., and Madara, J. L. (1991) Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction. J. Clin. Invest. 88, 1605-1612
20. +-de pendent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta 1208, 151-156
21. Griffiths, W. J., Yang, Y., Sjovall, J., and Lindgren, J. Å. (1996) Electrospray/collision-indnced dissociation mass spectrometry of mono-, di- and tri-hydroxylated lipoxygenase products, including leukotrienes of the B-series and lipoxins. Rapid Commun. Mass Spectrom. 10, 183-196
22. Clària, J., Lee, M. H., and Serhan, C. N. (1996) Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Mol. Med. 2, 583-596
23. +-dependent 15-hydroxyprostaglandin dehydrogenase. Biochem. Biophys. Res. Commun. 129, 268-274
24. 4 receptor. J. Exp. Med. 180, 253-260
25. Thierauch, K.-H., Dinter, H., and Stock, G. (1994) Prostaglandins and their receptors: II. Receptor structure and signal transduction. J. Hypertens. 12, 1-5
26. 4 stable analogues. J. Clin. Invest. In Press
27. Martin, P. (1997) Wound healing - aiming for perfect skin regeneration. Science 276, 75-81