LC-MS/MS identification of in vitro metabolites of a new H+/K+ ATPase inhibitor, KR-60436 produced by rat and human liver microsomes

Journal of Pharmaceutical and Biomedical Analysis

Volumn 28, Issue 5, 2002, Pages 897-902

  Choi, Sung Jin ^a   Ji, Hye Young ^a   Baek, Soo Kyung ^a   Lee, Hee Yong ^a   Choi, Joong Kwon ^b   Cheon, Hyae Gyeong ^b   Lee, Dong Ha ^c   Lim, Hong ^c   Lee, Hye Suk ^a  

^a Wonkwang University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Dongbu Hannong Chemical Co   (South Korea)

Author keywords

In vitro metabolism; KR 60436; LC ESI MS; Liver microsomes

Indexed keywords

1 (4 METHOXY 2 METHYLPHENYL) 4 [(2 HYDROXYETHYL)AMINO] 6 TRIFLUOROMETHOXY 2,3 DIHYDROPYRROLO[3,2 C]QUINOLINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; KR 60436; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PYRROLE; PYRROLE DERIVATIVE; QUINOLINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; DEALKYLATION; DEMETHYLATION; DRUG IDENTIFICATION; DRUG METABOLISM; HYDROXYLATION; IN VITRO STUDY; LIVER MICROSOME; MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; H(+)-K(+)-EXCHANGING ATPASE; HUMANS; MALE; MICROSOMES, LIVER; PYRROLES; QUINOLINES; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0036605374     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(01)00696-3     Document Type: Article

References (9)