Cancer modifier alleles inhibiting lung tumorigenesis are common in inbred mouse strains

International Journal of Cancer

Volumn 99, Issue 4, 2002, Pages 555-559

  Manenti, Giacomo ^a   Acevedo, Abraham ^b   Galbiati, Federica ^a   Barrera, Roberto Giannfi ^a   Noci, Sara ^a   Salido, Eduardo ^b   Dragani, Tommaso A ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Cancer modifier; Genetic predisposition; Par loci; Pas1; Urethane

Indexed keywords

GENE PRODUCT; PROTEIN PAR; PROTEIN PAS1; UNCLASSIFIED DRUG;

ALLELISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE LOCUS; GENETIC SUSCEPTIBILITY; LUNG ADENOMA; LUNG CANCER; LUNG CARCINOGENESIS; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ADENOMA; ALLELES; ANIMALS; CARCINOGENS; GENE DOSAGE; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED STRAINS; PHENOTYPE; URETHANE;

EID: 0036605087     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10386     Document Type: Article

References (23)

1. The genetic basis of susceptibility to lung tumors in mice
2. A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6
3. Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19
4. At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice
5. Linkage disequilibrium and physical mapping of Pas1 in mice
6. Quantitative analysis of genetic susceptibility to liver and lung carcinogenesis in mice
7. Genetic mapping of a pulmonary adenoma resistance locus (Par1) in mouse
8. Genetic resistance to urethane-induced pulmonary adenomas in SMXA recombinant inbred mouse strains
9. Pas1 is a common lung cancer susceptibility locus in three mouse strains
10. Major effect on susceptibility to urethane-induced pulmonary adenoma by a single gene in BALB/cBy mice
11. Identification of the Par2 (pulmonary adenoma resistance) locus on mouse chromosome 18, a major genetic determinant for lung carcinogen resistance in BALB/cByJ mice
12. Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression
13. At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J X BALB/c mice
14. Genetic analysis of susceptibility to induced pulmonary tumors in mice
15. Associations between both genetic and environmental biomarkers and lung cancer: Evidence of a greater risk of lung cancer in women smokers
16. Bacterial artificial chromosome libraries for mouse sequencing and functional analysis
17. Lung adenoma structure among inbred strains of mice: The pulmonary adenoma histologic type (Pah) genes
18. The association between atypical adenomatous hyperplasia and primary lung cancer
19. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
20. Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene
21. K-ras oncogene activation in atypical alveolar hyperplasias of the human lung
22. Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice