Tumor promoting effect of phenolphthalein on development of lung tumors induced by N-ethyl-N-nitrosourea in transgenic mice carrying human prototype c-Ha-ras gene

Journal of Veterinary Medical Science

Volumn 64, Issue 6, 2002, Pages 489-493

  Imaoka, Masako ^a   Kashida, Yoko ^a   Watanabe, Takao ^a   Ueda, Makoto ^b   Onodera, Hiroshi ^b   Hirose, Masao ^b   Mitsumori, Kunitoshi ^a,b  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Lung tumor; Phenolphthalein; rasH2 mouse; Tumor promotion

Indexed keywords

MUS MUSCULUS;

CARCINOGEN; CYCLINE; ETHYLNITROSOUREA; PHENOLPHTHALEIN;

ADENOCARCINOMA; ADENOMA; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; METABOLISM; MOUSE; ONCOGENE RAS; PATHOLOGY; RANDOMIZATION; TRANSGENIC MOUSE;

ADENOCARCINOMA; ADENOMA; ANIMALS; CARCINOGENS; ETHYLNITROSOUREA; FEMALE; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; PHENOLPHTHALEIN; PROLIFERATING CELL NUCLEAR ANTIGEN; RANDOM ALLOCATION;

EID: 0036597883     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.64.489     Document Type: Article

References (17)

1. Doi, ST., Kimura, M. and Katsuki, M. 1994. Site-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice. Jpn J Cancer Res. 85: 801-807.
2. Dunnick, J. K. and Hailey, J. R. 1996. Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems. Cancer Res. 56: 4922-4926.
3. Dunnick, J. K., Haedisty, J. F., Herbert, R. A., Seely, J. C., Furedi-Machacek, E. M., Foley, J. F., Lacks, G. D., Stasiewicz, S. and French, J. E. 1997. Phenolphthalein induces thymic lymphomas accompanied by loss of the p53 wild type allele in heterozygous p53-deficient (±) mice. Toxicol. Pathol. 25: 533-540.
4. Koujitani, T., Yasuhara, K., Usui. T., Nomura, T., Onodera, H., Takagi, H., Hirose, M. and Mitsumori, K. 2000. Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study. Cancer Lett. 152: 211-216.
5. Mitsumori, K. Evaluation on carcinogenicity of chemicals using transgenic mice. Proceeding of ICT-IX. Toxicology (in press).
6. Mitsumori, K., Wakana, S., Yamamoto, S., Kodama, Y., Yasuhara, K., Nomura, T., Hayashi, Y. and Maronpot, R. R. 1997. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors. Mol. Carcinog. 20: 298-307.
7. Mitsumori, K., Koizumi, H., Nomura, T. and Yamamoto, S. 1998. Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies. Toxicol. Pathol. 26: 520-531.
8. National Toxicology Program (NTP). 1996. Toxicology and carcinogenesis studies of phenolphthalein in F344/N rats and B6C3F1 mice (feed studies). NTP Technical Report No. 465, US Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda.
9. National Research Council. 1996. Guide for the Care and Use of Laboratory Animals. National Academy Press. Washington, D.C.
10. Ogawa, K., Imaida, K., Masui, T., Kawabe, M., Hasegawa, R., Kato, K., Ito, N. and Shirai, T. 1996. Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene. Carcinogenesis. 17: 341-345.
11. Saitoh, A., Kimura, M., Takahashi, R., Yokoyama, M., Nomura. T., Izawa, M., Sekiya, T., Nishimura, S. and Katsuki, M. 1990. Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5: 1195-1200.
12. Umemura, T., Kodama, Y., Hioki, K., Inoue, T., Nomura, T. and Kurokawa, Y. 1999. Susceptibility to urethane carcinogensis of transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) and its modification by butylhydroxytoluene. Cancer Lett. 145: 101-106.
13. Urano, K., Koizumi, H., Nagase, S., Watanabe, Y., Jiang, H., Nomura, T. and Yamamoto, S. 2000. Rapid carcinogenic response of transgenic mice harboring the human prototype c-Ha-ras gene to various carcinogens. Prog. Clin. Biol. Res. (in press).
14. Yamamoto, S., Hayashi, Y., Mitsumori, K. and Nomura, T. 1997. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene. Lab. Anim. Sci. 47: 121-126.
15. Yamamoto, S., Urano, K., Koizumi, H., Wakana, S., Hioki, K., Mitsumori, K., Kurosawa, K., Hayashi, Y. and Nomura, T. 1998. Validation of transgenic mice carrying human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Environ. Health Perspect. 106: 57-69.
16. Yamamoto, S., Mitsumori, K., Kodama, Y., Matsunuma, N., Manabe, S., Okamiya, H., Suzuki, H., Fukuda, T., Sakamaki, Y., Sunaga, M., Nomura, G., Hioki, K., Wakana, S., Nomura, T. and Hayashi, Y. 1996. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17: 2455-2461.
17. Vesselinovitch, S. D., Rao, K. V. N., Mihailovich, N., Rice, J. M. and Lombard, L. S. 1974. Development of a broad spectrum of tumors by ethylnitrosourea in mice and the modifying role of age, sex and strain. Cancer Res. 34: 2530-2538.