The effects of NMDA receptor antagonist MK-801 on lipid peroxidation during focal cerebral ischemia in rats

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 26, Issue 5, 2002, Pages 871-877

  Serteser, Mustafa ^a   Ozben, Tomris ^b   Gumuslu, Saadet ^b   Balkan, Sevin ^b   Balkan, Esor ^b  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

^b AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Conjugated dienes; Focal ischemia; Malondialdehyde; MK 801

Indexed keywords

ALKADIENE; DIZOCILPINE; GLUTAMATE RECEPTOR; LIPID PEROXIDE; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN LEVEL; CEREBELLUM; CONJUGATION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; RAT;

ALKENES; ANIMALS; BRAIN CHEMISTRY; BRAIN ISCHEMIA; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0036592269     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(01)00332-3     Document Type: Article

References (55)

1. Ali C., Docagne F., Nicole O., Lesne S., Toutain J., Young A., Chazalviel L., Divoux D., Caly M., Cabal P., Derlon J.M., McKenzie E.T., Buisson A., Vivien D. Increased expression of transforming growth factor-beta after cerebral ischemia in the baboon: an endogenous marker of neuronal stress? J. Cereb. Blood Flow Metab. 21(7):2001;820-827.
2. Ardelt B.K., Borowitz S.L., Maduh E.U., Swain S.L., Isom G.E. Cyanide induced lipid peroxidation in different organs: subcellular distribution and hydroperoxide generation in neuronal cells. Toxicology. 89(2):1994;127-137.
3. Auer R.N. Combination therapy with U74006F (Trilazad Mesylate), MK-801, insulin and diazepam in transient forebrain ischemia. Neurol. Res. 17(2):1995;132-136.
4. Bal-Price A., Brown G.C. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neurosci. 21(17):2001;6480-6491.
5. Balkan E., Balkan S., Ozben T., Serteser M., Gumuslu S., Oguz N. The effects of nitric oxide synthase inhibitor, L-NAME on NO production during focal cerebral ischemia in rats: could L-NAME be the future treatment of sudden deafness? Int. J. Neurosci. 89:1997;61-77.
6. Balkan S., Ozben T., Balkan E., Oguz N., Serteser M., Gumuslu S. Effects of lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats. Acta Neurol. Scand. 95(3):1997;140-146.
7. Barone F.C., Irving E.A., Ray A.M., Lee J.C., Kassis S., Kumar S., Badger A.M., Legos J.J., Erhardt J.A., Ohlstein E.H., Hunter A.J., Harrison D.C., Philpott K., Smith B.R., Adams J.L., Parson A.A. Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. Med. Res. Rev. 21(2):2001;129-145.
8. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A. 87:1990;1620-1624.
9. Beech J.S., Reckless J., Mosedale D.E., Grainger D.J., Williams S.C., Menon D.K. Neuroprotection in ischemia-reperfusion injury: an antiinflammatory approach using a novel broad-spectrum chemokine inhibitor. J. Cereb. Blood Flow Metab. 21(6):2001;683-689.
10. Block F., Schmidt W., Nolden-Koch M., Schwarz M. Rolipram reduces excitotoxic neuronal damage. NeuroReport. 12(7):2001;1507-1511.
11. Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. U.S.A. 86:1989;9030-9033.
12. Che X., Ye W., Panga L., Wu D.C., Yang G.Y. Monocyte chemoattractant protein-1 expressed in neurones and astrocytes during focal ischemia in mice. Brain Res. 902(2):2001;171-177.
13. Chen S.T., Hsu C.Y., Hogan E.L., Maricq H., Balentine J.D. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarct. Stroke. 17:1986;738-743.
14. Ciuffi M., Gentilini G., Franchi M.S., Zilletti L. Effect of 21-aminosteroid U74500A on rat brain cortex lipid peroxidation induced "in vivo" by iron-carbohydrate. Biochem. Pharmacol. 47(12):1994;2181-2186.
15. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science. 262:1993;689-695.
16. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical culture. Proc. Natl. Acad. Sci. U.S.A. 88:1991;6371-6868.
17. Draper H.H., McGirr L.G., Hadley M. The metabolism of malondialdehyde. Lipids. 21(4):1986;305-307.
18. Fulham M.J., Brooks R.A., Hallett M., Di-Chiro G. Cerebellar diaschisis revisited: pontine hypometabolism and dentate sparing. Neurology. 42:1992;2267-2273.
19. Garthwaite J., Garthwaite G., Palmer R.M.J., Moncada S. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur. J. Pharmacol. 172:1989;413-416.
20. Goel R., Mishra O.P., Papadopoulos M.D. Effect of dithiothreitol on lipid peroxidation induced modification of NMDA receptor in fetal guinea pig brain. Neurosci. Lett. 169(1 and 2):1994;109-113.
21. Gutteridge J.M.C. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem. 41(12):1995;1819-1828.
22. Horakowa L., Lukovic L., Uraz V., Stolc S. Time course of lipid peroxidation during incomplete ischemia followed by reperfusion in rat brain. Physiol. Bohemoslov. 39(6):1990;513-517.
23. 2. Eur. J. Cardiothoracic Surg. 9(8):1995;410-418.
24. Jander S., Schroeter M., Stoll G. Role of NMDA receptor signalling in the regulation of inflammatory gene expression after focal brain ischemia. J. Neuroimmunol. 109(2):2000;181-187.
25. Jander S., Schroeter M., Peters O., Witte O.W., Stoll G. Cortical spreading depression induces proinflammatory cytokine gene expression in the rat brain. J. Cereb. Blood Flow Metab. 21(3):2001;218-225.
26. Jesberger J.A., Richardson J.S. Oxygen free radicals and brain dysfunction. Int. J. Neurosci. 57:1991;1-17.
27. Kinuta Y., Kikuchi H., Ishikawa M., Kimura M., Itokawa Y. Lipid peroxidation in focal cerebral ischemia. J. Neurosurg. 71:1989;421-429.
28. Lazzarino G., Tavazzi B., Di-Pierro D., Vaonozzi R., Penco M., Giardina B. The relevance of malondialdehyde as a biochemical index of lipid peroxidation of postischemic tissues in the rat and human beings. Biol. Trace Elem. Res. 47(1-3):1995;165-170.
29. Leach M.J., Swan J.H., Eisenthal D., Dopson M., Nobbs M. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke. 24:1993;1063-1067.
30. Lowry O.H., Rosenbrough N.J., Farr A.L., Randell R.J. Protein measurement with folin-phenol reagent. J. Biol. Chem. 193:1951;265-275.
31. MacDermott A.B., Mayer M.L., Westbrook G.L. NMDA receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature. 321:1986;519.
32. Margaill I., Parmentier S., Callebert J., Allix M., Boulu R.G., Plotkine M. Short therapeutic window for MK-801 in transient focal cerebral ischemia in normotensive rats. J. Cereb. Blood Flow Metab. 16(1):1996;107-113.
33. Meldrum B. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clin. Sci. 68:1985;113-122.
34. Meldrum B. Protection against ischemic neuronal damage by drugs acting on excitatory neurotransmission. Cerebrovasc. Brain Metab. Rev. 2:1990;25-57.
35. Park C.K., Nehls D.G., Graham D.I., Teasdale G.M., McCulloch J. The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann. Neurol. 24(1):1988;543-551.
36. Peng H., Wen T.C., Tanaka J., Maeda N., Matsuda S., Desaki J., Sudo S., Zhang B., Sakanaka M. Epidermal growth factor protects neuronal cells in vivo and in vitro against transient forebrain ischemia- and free radical-induced injuries. J. Cereb. Blood Flow Metab. 18(4):1998;349-360.
37. Radi R., Beckman J.S., Bush K.M., Freeman B.A. Peroxynitrite oxidation of sulfohydryls: the cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266:1991;4244-4250.
38. Recknagel R.O., Glende E.A. Spectrophotometric detection of lipid conjugated dienes. Packer L. Methods in Enzymology. vol. 105:1984;331-337 Academic Press, New York.
39. Rothman S.M., Olney J.W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19:1986;101-111.
40. Rothman S.M., Olney J.W. Excitotoxicity and the NMDA receptor. Trends Neurosci. 10:1987;299-302.
41. Sakashita Y., Matsuda H., Kakuda K., Takamori M. Hypoperfusion and vasoreactivity in the thalamus and cerebellum after stroke. Stroke. 24:1993;84-87.
42. Scatton B. Excitatory amino acid receptor antagonists. A novel treatment for ischemic cerebrovascular diseases. Science. 55:1994;25-26.
43. Schurr A., Payne R.S., Meine M.P., Rigon B.M. Hypoxia, excitotoxicity and neuroprotection in the hippocampal slice preparation. J. Neurosci. Methods. 59(1):1990;129-138.
44. Schwab J.M., Nguyen T.D., Meyermann R., Schluesener H.J. Human focal cerebral infarctions induce differential lesional interleukin-16 (IL-16) expression confined to infiltrating granulocytes, CD8+ T-lymphocytes and activated microglia/macrophages. J. Neuroimmunol. 114(1 and 2):2001;232-241.
45. Serteser M., Ozben T., Gumuslu S., Balkan S., Balkan E. Biochemical evidence of crossed cerebellar diaschisis in terms of nitric oxide indicators and lipid peroxidation products in rats during focal cerebral ischemia. Acta Neurol. Scand. 103(1):2001;43-48.
46. Sharp F.R., Lu A., Tang Y., Millhorn D.E. Multiple molecular penumbras after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 20(7):2000;1011-1032.
47. Southam E., East S.J., Garthwaite J. Excitatory amino acid receptors coupled to the nitric oxide/cyclic GMP pathway in rat cerebellum during development. J. Neurochem. 56:1991;2072-2081.
48. Taourel D.B., Guerin M.C., Torreilles J. Is malondialdehyde a valuable indicator of lipid peroxidation. Biochem. Pharmacol. 44(5):1992;985-988.
49. Vaonozzi R., Lazzarino G., Tavazzi B., Di-Pierro D., Siragusa P., Giuffre R., Giardina B. Incomplete cerebral ischemia in the rat provokes increase of tissue and plasma malondialdehyde. Biol. Trace Elem. Res. 47(1-3):1995;241-246.
50. Wasowicz W., Jean N., Peratz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin. Chem. 39(12):1993;2522-2526.
51. White B.C., Sullivan J.M., DeGracia D.J., O'Neil B.J., Neumar R.W., Grossman L.I., Rafols J.A., Krause G.S. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neurol. Sci. 179(S1 and S2):2000;1-33.
52. Wink D.A., Look J.A., Pacelli R., Liebmann J., Krishna M.C., Mitchell J.B. Nitric oxide protects against cellular damage by reactive oxygen species. Toxicol. Lett. 82 and 83:1995;221-226.
53. Wong J.W., Ebeler S.E., Isseroff R.R., Shibamoto T. Analysis of malondialdehyde in biological samples by capillary gas chromatography. Anal. Biochem. 220:1994;73-81.
54. Xu H.L., Feng Y.P. Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats. Acta Pharmacol. Sin. 21(5):2000;433-438.
55. Yamasaki Y., Itoyama Y., Kogure K. Involvement of cytokine production in pathogenesis of transient cerebral ischemic damage. Keio J. Med. 45(3):1996;225-229.