Effect of long-term treatment with inhaled budesonide or theophylline on lung function, airway reactivity and asthma symptoms

Respiratory Medicine

Volumn 96, Issue 6, 2002, Pages 432-438

  Dahl, R ^a   Larsen, B B ^a   Venge, P ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bronchial asthma; Budesonide; Inhaled glucocorticosteroid; Long term treatment

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; GLUCOCORTICOID; HISTAMINE; SALBUTAMOL; TERBUTALINE; THEOPHYLLINE; BRONCHODILATING AGENT;

ADULT; ARTICLE; ASTHMA; BRONCHUS REACTIVITY; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DETERIORATION; DILUTION; DISEASE CONTROL; DISEASE EXACERBATION; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; HOARSENESS; HUMAN; LONG TERM CARE; LUNG FUNCTION; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SYMPTOMATOLOGY; TREATMENT OUTCOME; INHALATIONAL DRUG ADMINISTRATION; LUNG; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHYSIOLOGY;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ASTHMA; BRONCHODILATOR AGENTS; BUDESONIDE; DOUBLE-BLIND METHOD; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LONG-TERM CARE; LUNG; MALE; MIDDLE AGED; THEOPHYLLINE; TREATMENT OUTCOME;

EID: 0036591414     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1053/rmed.2001.1280     Document Type: Article

References (25)

1. Glynn AA, Michaels L. Bronchial biopsy in chronic bronchitis and asthma. Thorax 1960; 15: 42-53.
2. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985; 131: 599-606.
3. Peat JK, Woolcock AJ, Cullen K. Rate of decline of lung function in subjects with asthma. Eur J Respir Dis 1987; 70: 171-179.
4. Gerritsen J, Koeter GH, Postma DS, Schouten JP, Knol K. Prognosis of asthma from childhood to adulthood. Am Rev Respir Dis 1989; 140: 1325-1330,
5. Fuglsang G, Hertz B, Holm EB. No protection by oral terbutaline against exercise-induced asthma in children: a dose-response study. Eur Respir J 1993; 6: 527-530.
6. Szefler SJ, Nelson HS. Alternative agents for anti-inflammatory treatment of asthma. J Allergy Clin Immunol 1998; 102: S23-S35.
7. Lim S, Tomita K, Carramori G, Jatakanon A, Oliver B, Keller A, Adcock I, Chung KF, Barnes PJ. Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. Am J Respir Crit Care Med 2001; 164: 273-276.
8. Barnes PJ. A new approach to the treatment of asthma. N Engl J Med 1989; 321: 1517-1527.
9. Kraan J, Koeter GH, vd Mark TW, Sluiter HJ, De Vries K. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline. J Allergy Clin Immunol 1985; 76: 628-636.
10. Waalkens HJ, Gerritsen J, Koeter GH, Krouwels FH, van Aalderen WM, Knol K. Budesonide and terbutaline or terbutaline alone in children with mild asthma: effects on bronchial hyperresponsiveness and diurnal variation in peak flow. Thorax 1991; 46: 499-503.
11. Kerrebijn KF, Essen-Zandvliet EE, Neijens HJ. Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol 1987; 79: 653-659.
12. Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, O'Byrne PM, Hargreave FE. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am Rev Respir Dis 1990; 142: 832-836.
13. Haahtela T, Jarvinen M, Kava T, Kiviranta K, Koskinen S, Lehtonen K, Nikander K, Persson T, Reinikainen K, Selroos O. Comparison of a beta-2 agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med 1991; 325: 388-392.
14. Kerstjens HA, Brand PL, Hughes MD, Robinson NJ, Postma DS, Sluiter HJ, Bleecker ER, Dekhuijzen PN, de Jong PM, Mengelers HJ. A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease. Dutch Chronic Non-Specific Lung Disease Study Group. N Engl J Med 1992; 327: 1413-1419.
15. Pedersen B, Dahl R, Karlstrom R, Peterson CG, Venge P. Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking. Am J Respir Crit Care Med 1996; 153: 1519-1529.
16. American Thoracic Society Commitee on Diagnostic Standards. Definitions and classification of chronic bronchitis, asthma, and pulmonary empaysema. Am Rev Respir Dis 1962; 85: 762.
17. Quanjer PHed. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J 1993; 16(Suppl): 1-95.
18. International Consensus Report on Diagnosis and Treatment of Asthma. Clin Exp Allergy 1992; 22(Supp) 1: 1-72.
19. Cockcroft DW, Killian DN, Mellon JJ, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1997; 7: 235-243.
20. Toogood JH. High-dose inhaled steroid therapy for asthma. J Allergy Clin Immunol 1989; 83: 528-536.
21. Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 1988; 137: 62-69.
22. Adelroth E, Rosenhall L, Johansson SA, Linden M, Venge P. Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline. Am Rev Respir Dis 1990; 142: 91-99.
23. Pedersen S, Hansen OR. Budesonide treatment of moderate and severe asthma in children: a dose-response study. J Allergy Clin Immunol 1995; 95: 29-33.
24. Wilson AM, Lipworth BJ. Dose-response evaluation of the therapeutic index for inhaled budesonide in patients with mild-to-moderate asthma. Am J Med 2000; 108: 269-275.
25. Lundgren R, Soderberg M, Horstedt P, Stenling R. Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. Eur Respir J 1988; 1: 883-889.