Polymorphic CAG repeat length within the androgen receptor gene: Identification of a subgroup of patients with increased risk of ovarian cancer

Oncology Reports

Volumn 9, Issue 3, 2002, Pages 639-644

  Santarosa, Manuela ^a   Bidoli, Ettore ^a   Gallo, Angelo ^a   Steffan, Agostino ^a   Boiocchi, Mauro ^a   Viel, Alessandra ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Androgen receptor; CAG repeat; Hereditary ovarian cancer; Ovarian cancer

Indexed keywords

ANDROGEN RECEPTOR;

ADULT; AGED; ALLELE; ARTICLE; CASE CONTROL STUDY; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; ITALY; MIDDLE AGED; NUCLEOTIDE REPEAT; OVARY TUMOR; RISK FACTOR; TRINUCLEOTIDE REPEAT;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; ITALY; MIDDLE AGED; OVARIAN NEOPLASMS; POLYMORPHISM, GENETIC; RECEPTORS, ANDROGEN; REPETITIVE SEQUENCES, NUCLEIC ACID; RISK FACTORS; TRINUCLEOTIDE REPEATS;

EID: 0036584922     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.3.639     Document Type: Article

References (35)

1. Szabo CI and King MC: Population genetics of BRCA1 and BRCA2. Am J Hum Genet 60: 1013-1020, 1997. (Pubitemid 27194085)
2. Lynch HT, Smyrk T and Lynch J: An update of HNPCC (Lynch syndrome). Cancer Genet Cytogenet 93: 84-99, 1997. (Pubitemid 27102493)
3. Fathalla MF: Incessant ovulation - a factor in ovarian neoplasia? Lancet 2: 163, 1971.
4. Cramer DW and Welch WR: Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis. J Natl Cancer Inst 71: 717-721, 1983. (Pubitemid 14232385)
5. Ness RB and Cottreau C: Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer Inst 91: 1459-1467, 1999. (Pubitemid 29424550)
6. Silva EG, Tornos C, Fritsche HA, El Naggar A, Gray K, Ordonez NG, Luna M and Gershenson D: The induction of benign epithelial neoplasms of the ovaries of guinea pigs by testosterone stimulation: a potential animal model. Mod Pathol 10: 879-883, 1997. (Pubitemid 27431961)
7. Helzlsouer KJ, Alberg AJ, Gordon GB, Longcope C, Bush TL, Hoffman SC and Comstock GW: Serum gonadotropins and steroid hormones and the development of ovarian cancer. JAMA 274: 1926-1930, 1995. (Pubitemid 26003062)
8. Thompson MA and Adelson MD: Aging and development of ovarian epithelial carcinoma: the relevance of changes in ovarian stromal androgen production. Adv Exp Med Biol 330: 155-165, 1993. (Pubitemid 23202999)
9. Kuhnel R, de Graaff J, Rao BR and Stolk JG: Androgen receptor predominance in human ovarian carcinoma. J Steroid Biochem 26: 393-397, 1987. (Pubitemid 17066083)
10. Chadha S, Rao BR, Slotman BJ, van Vroonhoven CC and van der Kwast TH: An immunohistochemical evaluation of androgen and progesterone receptors in ovarian tumors. Hum Pathol 24: 90-95, 1993. (Pubitemid 23046677)
11. Lau KM, Mok SC and Ho SM: Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proc Natl Acad Sci USA 96: 5722-5727, 1999. (Pubitemid 29234685)
12. Van Doorn HC, Burger CW, van der Valk P and Bonfrer HM: Oestrogen, progesterone, and androgen receptors in ovarian neoplasia: correlation between immunohistochemical and biochemical receptor analyses. J Clin Pathol 53: 201-205, 2000. (Pubitemid 30163603)
13. Davis M, Hitchcock A, Foulkes WD and Campbell IG: Refinement of two chromosome 11q regions of loss of heterozygosity in ovarian cancer. Cancer Res 56: 741-744, 1996. (Pubitemid 26055461)
14. Gabra H, Watson JE, Taylor KJ, Mackay J, Leonard RC, Steel CM, Porteous DJ and Smyth JF: Definition and refinement of a region of loss of heterozygosity at 11q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis. Cancer Res 56: 950-954, 1996. (Pubitemid 26065383)
15. Edelson MI, Lau CC, Colitti CV, Welch WR, Bell DA, Berkowitz RS and Mok SC: A one centimorgan deletion unit on chromosome Xq12 is commonly lost in borderline and invasive epithelial ovarian tumors. Oncogene 16: 197-202, 1998. (Pubitemid 28045105)
16. Chang CS, Kokontis J and Liao ST: Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 240: 324, 1988.
17. Beato M: Gene regulation by steroid hormones. Cell 56: 335-344, 1989.
18. Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA and Ostrander EA: Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res 57: 1194-1198, 1997. (Pubitemid 27138622)
19. Chamberlain NL, Driver ED and Miesfeld RL: The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 22: 3181-3186, 1994. (Pubitemid 24260654)
20. La Spada AR, Wilson EM, Lubahn DB, Harding AE and Fischbeck KH: Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352: 77-79, 1991. (Pubitemid 21896702)
21. Spurdle AB, Dite GS, Chen X, Mayne CJ, Southey MC, Batten LE, Chy H, Trute L, McCredie MR, Giles GG, Armes J, Venter DJ, Hopper JL and Chenevix Trench G: Androgen receptor exon 1 CAG repeat length and breast cancer in women before age forty years. J Natl Cancer Inst 91: 961-966, 1999. (Pubitemid 29272523)
22. Rebbeck TR, Kantoff PW, Krithivas K, Neuhausen S, Blackwood MA, Godwin AK, Daly MB, Narod SA, Garber JE, Lynch HT, Weber BL and Brown M: Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat. Am J Hum Genet 64: 1371-1377, 1999. (Pubitemid 30468755)
23. Yu H, Bharaj B, Vassilikos EJ, Giai M and Diamandis EP: Shorter CAG repeat length in the androgen receptor gene is associated with more aggressive forms of breast cancer. Breast Cancer Res Treat 59: 153-161, 2000. (Pubitemid 30216138)
24. Spurdle AB, Webb PM, Chen X, Martin NG, Giles GG, Hopper JL and Chenevix Trench G: Androgen receptor exon 1 CAG repeat length and risk of ovarian cancer. Int J Cancer 87: 637-643, 2000. (Pubitemid 30620404)
25. Levine DA and Boyd J: The androgen receptor and genetic susceptibility to ovarian cancer: results from case series. Cancer Res 61: 908-911, 2001. (Pubitemid 32174401)
26. Santarosa M, Viel A, Dolcetti R, Crivellari D, Magri MD, Pizzichetta MA, Tibiletti MG, Gallo A, Tumolo S, Del Tin L and Boiocchi M: Low incidence of BRCA1 mutations among Italian families with breast and ovarian cancer. Int J Cancer 78: 581-586, 1998. (Pubitemid 28507181)
27. Santarosa M, Dolcetti R, Magri MD, Crivellari D, Tibiletti MG, Gallo A, Tumolo S, Della Puppa L, Furlan D, Boiocchi M and Viel A: BRCA1 and BRCA2 genes: role in hereditary breast and ovarian cancer in Italy. Int J Cancer 83: 5-9, 1999. (Pubitemid 29409468)
28. Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Dahl D, Brufsky A, Talcott J, Hennekens CH and Kantoff PW: The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 94: 3320-3323, 1997. (Pubitemid 27157309)
29. Breslow NE and Day NE: Statistical methods in cancer research. Vol I. The analysis of case-control studies. IARC Scientific Publications No. 32. IARC, Lyon, 1980.
30. Kazemi Esfarjani P, Trifiro MA and Pinsky L: Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor: possible pathogenetic relevance for the (CAG)n-expanded neuronopathies. Hum Mol Genet 4: 523-527, 1995.
31. Dowsing AT, Yong EL, Clark M, McLachlan RI, de Kretser DM and Trounson AO: Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene. Lancet 354: 640-643, 1999. (Pubitemid 29391429)
32. Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF and Coetzee GA: Breast cancer susceptibility gene 1 (BRCA1) is a coactivator of the androgen receptor. Cancer Res 60: 5946-5949, 2000.
33. Yeh S, Hu YC, Rahman M, Lin HK, Hsu, CL, Ting HJ, Kang HY and Chang C: Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. Proc Natl Acad Sci USA 97: 11256-11261, 2000.
34. Moslehi R, Chu W, Karlan B, Fishman D, Risch H, Fields A, Smotkin D, Ben David Y, Rosenblatt J, Russo D, Schwartz P, Tung N, Warner E, Rosen B, Friedman J, Brunet JS and Narod SA: BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer. Am J Hum Genet 66: 1259-1272, 2000. (Pubitemid 30468783)
35. Warner E, Foulkes W, Goodwin P, Meschino W, Blondal J, Paterson C, Ozcelik H, Goss P, Allingham Hawkins D, Hamel N, Di Prospero L, Contiga V, Serruya C, Klein M, Moslehi R, Honeyford J, Liede A, Glendon G, Brunet JS and Narod S: Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer. J Natl Cancer Inst 91: 1241-1247, 1999. (Pubitemid 29357191)