Androgen receptor exon 1 CAG repeat length and breast cancer in women before age forty years

Journal of the National Cancer Institute

Volumn 91, Issue 11, 1999, Pages 961-966

  Spurdle, Amanda B ^a   Dite, Gillian S ^b   Chen, Xiaoqing ^a   Mayne, Carol J ^a   Southey, Melissa C ^c   Batten, Leigh E ^c   Chy, Hun ^c   Trute, Lynne ^c   McCredie, Margaret R E ^d,e   Giles, Graham G ^f   Armes, Jane ^c   Venter, Deon J ^f   Hopper, John L ^b   Chenevix Trench, G ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d CANCER RESEARCH DIVISION   (Australia)

^e UNIVERSITY OF OTAGO   (New Zealand)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR;

ADULT; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA STRUCTURE; FAMILY STUDY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NUCLEOTIDE REPEAT; ONSET AGE; POPULATION RESEARCH; PRIORITY JOURNAL; RISK FACTOR;

EID: 0033516319     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/91.11.961     Document Type: Article

References (20)

1. Hopper JL, Carlin JB. Familial aggregation of a disease consequent upon correlation between relatives in a risk factor measured on a continuous scale. Am J Epidemiol 1992;136: 1138-47.
2. Easton D, Peto J. The contribution of inherited predisposition to cancer incidence. Cancer Surv 1990;9:395-416.
3. Irvine RA, Yu MC, Ross RK, Coetzee GA. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res 1995;55:1937-40.
4. Ingles SA, Ross RK, Yu MC, Irvine RA, La Pera G, Haile RW, et al. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst 1997;89:166-70.
5. Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA, et al. Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res 1997;57:1194-8.
6. Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Dahl D, Brufsky A, et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer [published erratum appears in Proc Natl Acad Sci U S A 1997;94:8272]. Proc Natl Acad Sci USA 1997;94:3320-3.
7. Hakimi JM, Schoenberg MP, Rondinelli RH, Piantadosi S, Barrack ER. Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer. Clin Cancer Res 1997;3: 1599-608.
8. Hardy DO, Scher HI, Bogenreider T, Sabbatini P, Zhang ZF, Nanus DM, et al. Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J Clin Endocrinol Metab 1996;81:4400-5.
9. Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994;22:3181-6.
10. La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991;352:77-9.
11. MacLean HE, Choi WT, Rekaris G, Warne GL, Zajac JD. Abnormal androgen receptor binding affinity in subjects with Kennedy's disease (spinal and bulbar muscular atrophy). J Clin Endocrinol Metab 1995;80:508-16.
12. Tut TG, Ghadessy FJ, Trifiro MA, Pinsky L, Yong EL. Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. J Clin Endocrinol Metab 1997;82:3777-82.
13. Wooster R, Mangion J, Eeles R, Smith S, Dowsett M, Averill D, et al. A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome. Nat Genet 1992;2: 132-4.
14. Lobaccaro JM, Lumbroso S, Belon C, Galtier-Dereure F, Bringer J, Lesimple T, et al. Male breast cancer and the androgen receptor gene. Nat Genet 1993;5:109-10.
15. Zhu X, Daffada AA, Chan CM, Dowsett M. Identification of an exon 3 deletion splice variant androgen receptor mRNA in human breast cancer. Int J Cancer 1997;72:574-80.
16. Rebbeck TR, Kantoff PW, Krithivas K, Narod SA, Godwin AK, Daly MB, et al. Modification of breast cancer risk in BRCA1 mutation carriers by the androgen receptor CAG repeat polymorphism [abstract]. Proc Am Assoc Cancer Res 1998;39:366.
17. McCredie MR, Dite G, Giles GG, Hopper JL. Breast cancer in Australian women under the age of 40. Cancer Causes Control 1998;9: 189-98.
18. Southey MC, Batten LE, McCredie MR, Giles GG, Dite G, Hopper JL, et al. Estrogen receptor polymorphism at codon 325 and risk of breast cancer in women before age forty. J Natl Cancer Inst 1998;90:532-6.
19. Allred DC, Clark GM, Elledge R, Fuqua SA, Brown RW, Chamness GC, et al. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in nodenegative breast cancer. J Natl Cancer Inst 1993;85:200-6.
20. StataCorp. Stata statistical software: release 5.0. College Station (TX): Stata Corp.; 1997.