Reduced Mg2+ blockade of synaptically activated N-methyl-D-aspartate receptor-channels in CA1 pyramidal neurons in kainic acid-lesioned rat hippocampus

Neuroscience

Volumn 88, Issue 3, 1999, Pages 727-739

  Chen, Y ^a   Chad, J E ^b   Cannon, R C ^b   Wheal, H V ^b  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

AMPA; Epilepsy; EPSC; GABA; In vitro; NMDA

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMPA RECEPTOR; KAINIC ACID; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; 2 AMINO 5 PHOSPHONOVALERIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DRUG DERIVATIVE; LIDOCAINE; LIDOCAINE ETHOBROMIDE; MAGNESIUM; QX-314;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; EPILEPSY; HIPPOCAMPUS; HIPPOCAMPUS POTENTIAL; KINDLING; MALE; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL PLASTICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; DRUG EFFECT; ELECTROSTIMULATION; EVOKED RESPONSE; IN VITRO STUDY; PATCH CLAMP; PHYSIOLOGY; REFERENCE VALUE; WISTAR RAT;

2-AMINO-5-PHOSPHONOVALERATE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ELECTRIC STIMULATION; EVOKED POTENTIALS; HIPPOCAMPUS; KAINIC ACID; LIDOCAINE; MAGNESIUM; MALE; MODELS, NEUROLOGICAL; PATCH-CLAMP TECHNIQUES; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; REFERENCE VALUES; SYNAPTIC TRANSMISSION;

EID: 0032587721     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00253-X     Document Type: Article

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