Structural damage induced by peroxidation may account for functional impairment of heavy synaptic mitochondria

Free Radical Research

Volumn 36, Issue 4, 2002, Pages 479-484

  Battino, Maurizio ^a   Ferreiro, Maria S ^b   Littarru, GianPaolo ^a   Quiles, José L ^c   Ramrez Tortosa, M Carmen ^c   Huertas, Jesús R ^c   Mataix, José ^c   Villa, Roberto F ^d   Gorini, Antonella ^d  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF SEVILLE   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

Aging; Coenzyme Q; Hydroperoxides; Peroxidation; Rat brain mitochondria

Indexed keywords

FATTY ACID; HYDROPEROXIDE; PHOSPHOLIPID; UBIQUINONE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN REGION; BRAIN SYNAPTOSOME; CELL DAMAGE; CELL STRUCTURE; CELL SUBPOPULATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HYPOTHESIS; MITOCHONDRION; NONHUMAN; PEROXIDATION; RAT; RESPIRATORY CHAIN;

AGE FACTORS; AGING; ANIMALS; ANTIOXIDANTS; BRAIN; FATTY ACIDS; FEMALE; LIPID PEROXIDATION; LIPID PEROXIDES; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; UBIQUINONE; VITAMIN E;

ANIMALIA;

EID: 0036554586     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760290021351     Document Type: Article

References (25)

1. Battino, M., Ferri, E., Gorini, A., Villa, R.F., Huertas, J.F.R., Fiorella, P., Genova, M.L., Lenaz, G. and Marchetti, M. (1990) "Natural distribution and occurrence of coenzyme Q homologues", Membr. Biochem. 9, 179-190.
2. Battino, M., Bertoli, E., Formiggini, G., Sassi, S., Gorini, A., Villa, R.F. and Lenaz, G. (1991) "Structural and functional aspects of the respiratory chain of synaptic and non-synaptic mitochondria derived from selected brain regions", J. Bioenerg. Biomembr. 23, 345-363.
3. Battino, M., Gorini, A., Villa, R.F., Genova, M.L., Bovina, C., Sassi, S., Littarru, G.P. and Lenaz, G. (1995) "Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat", Mech. Ageing Dev. 78, 173-187.
4. Battino, M., Svegliati Baroni, S., Littarru, G.P., Bompadre, S., Leone, L., Gorini, A. and Villa, R.F. (1997) "Coenzyme Q homologs and vitamin E in synaptic and non-synaptic occipital cerebral cortex mitochondria in the ageing rat", Mol. Asp. Med. 18, s279-s282.
5. Battino, M. (2001) "Natural distribution and occurrence of coenzyme Q homologues in mammals", In: Ebadi, M., Marwah, J. and Chopra, R.K., eds, Mitochondrial Ubiquinone (Coenzyme Q10): Biochemical, Functional, Medical and Therapeutic Aspects in Human Health and Disease (Prominent Press, Scottsdale), pp 151-182.
6. Villa, R.F., Gorini, A., Geroldi, D., Lo Faro, A. and Dell'Orbo, C. (1989) "Enzyme activities in perikaryal and synaptic mitochondrial fractions from rat hippocampus during development", Mech. Ageing Dev. 49, 211-225.
7. Villa, R.F. and Gorini, A. (1991) "Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging", Neurochem. Res. 10, 1125-1132.
8. Lai, J.C.K., Walsh, J.M., Dennis, S.C. and Clark, J.B. (1977) "Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization", J. Neurochem. 28, 625-631.
9. Hansford, R.G. (1983) "Bioenergetics; in aging", Biochim. Biophys. Acta 726, 41-80.
10. Villa, R.F., Gorini, A., Lo Faro, A. and Dell'Orbo, C. (1989) "A critique on the preparation and enzymatic characterization of synaptic and non-synaptic mitochondria from hippocampus", Cell. Mol. Neurobiol. 9, 247-262.
11. Kirischuk, S., Neuhaus, J., Verkhratsky, A. and Kettenmann H. (1995) "Preferential localization of active mitochondria in process tips of immature retinal oligodendrocytes", Neuroreport 6, 737-741.
12. Gorini, A., D'Angelo, A. and Villa, R.F. (1998) "Action of L-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex", Neurochem. Res. 23, 1485-1491.
13. Vanella, A., Villa, R.F., Gorini, A., Campisi, A. and Giuffrida-Stella, A.M. (1989) "Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging", J. Neurosci. Res. 22, 351-355.
14. Nohl, H., Gille, L., Schonheit, K. and Liu, Y. (1996) "Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen", Free Radic. Biol. Med. 20, 207-213.
15. Turrens, J.F. (1997) "Superoxide production by the mitochondrial respiratory chain", Biosci. Rep. 17, 3-8.
16. Kröger, A. (1978) "Determination of contents and redox state of ubiquinone and menadione", Methods Enzymol. 53, 579-591.
17. Nourouz-Zadeh, J., Sarmadi-tajaddini, J. and Wolff, S.P. (1994) "Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine", Anal. Biochem. 220, 403-409.
18. Lepage, G. and Roy, C.C. (1986) "Direct transesterification of all classes of lipids in a one-step reaction", J. Lipid Res. 27, 114-120.
19. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) "Protein measurement with the Folin phenol reagent", J. Biol. Chem. 193, 265-275.
20. Marinetti, G.V. (1962) "Chromatographic separation, identification and analysis of phosphatides", J. Lipid Res. 3, 1-20.
21. Huertas, J.R., Battino, M., Lenaz, G. and Mataix, F.J. (1991) "Changes in mitochondrial and microsomal rat liver coenzyme Q9 and Q10 content induced by dietary fat and endogenous lipid peroxidation", FEBS Lett. 287, 89-92.
22. Mataix, J., Quiles, J.L., Huertas, J.R., Battino, M. and Mañas, M. (1998) "Tissue specific interactions of exercise, dietary fatty acids, and vitamin E in lipid peroxidation", Free Radic. Biol. Med. 24, 511-521.
23. Periago, J.L., Suarez, M.D. and Pita, M.L. (1990) "Effect of dietary olive oil, corn oil and medium chain triglycerides on the lipid composition of rat red blood cell membranes", J. Nutr. 120, 986-994.
24. Huertas, J.R., Battino, M., Barzanti, V., Maranesi, M., Parenti-Castelli, G., Littarru, G.P., Turchetto, E., Mataix, F.J. and Lenaz, G. (1992) "Mitochondrial and microsomal cholesterol mobilization after oxidative stress induced by adriamycin in rats fed with dietary olive and corn oil", Life Sci. 50, 2111-2118.
25. Quiles, J.L., Huertas, J.R., Mañas, M. and Mataix, J. (1999) "Physical exercise affects the lipid profile of mitochondiral membranes in rats fed with virgin olive oil or sunflower oil", Br. J. Nutr. 81, 21-24.