Establishment of tsA58 transgenic rats as a source of conditionally immortalized cell lines with differentiated functions

Experimental Animals

Volumn 51, Issue 2, 2002, Pages 113-118

  Takahashi, Ri Ichi ^a  

^a YS New Technology Institute Inc   (Japan)

Author keywords

Temperature sensitive large T antigen; Transgenic rat

Indexed keywords

SIMIAE; SIMIAN VIRUS 40;

VIRUS T ANTIGEN;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; GENETIC PROCEDURES; GENETICS; MUTATION; PROMOTER REGION; RAT; SIMIAN VIRUS 40; SPECIES DIFFERENCE; TEMPERATURE; TRANSGENIC ANIMAL; VIRUS GENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL DIFFERENTIATION; CELL LINE; CYTOLOGICAL TECHNIQUES; GENES, VIRAL; GENETIC TECHNIQUES; MUTATION; PROMOTER REGIONS (GENETICS); RATS; SIMIAN VIRUS 40; SPECIES SPECIFICITY; TEMPERATURE;

EID: 0036545564     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.51.113     Document Type: Review

References (20)

1. Allen, K.J., Reyes, R., Demmler, K., Mercer, J.F., Williamson, R., and Whitehead, R.H. 2000. Conditionally immortalized mouse hepatocytes for use in liver gene therapy. J. Gastroenterol. Hepatol. 15: 1325-1332.
2. Baker, H.J., Lindsey, J.R., and Weisbrith, M. 1979. The Laboratory rat. Vols. 1 and 2 New York Academic Press.
3. Charreau, B., Tesson, L., Soulillou, J.P., Pourcel, C., and Anegon, I. 1996. Transgenesis in rats: technical aspects and models. Transgenic Res. 5: 223-234.
4. Gill, T., Smith, G.J., Wissler, R.W., and Kunz, H.W. 1989. The rat as an experimental animal. Science 245, 269-276.
5. Hakamada, K., Tahara, K., Uchida, H., Sakuma, Y., Nakamura, M., Kume, A., Murakami. T., Takahashi, M., Takahashi, R., Hirabayashi, M., Ueda, M., Miyoshi, I., Kasai, N., and Kobayashi, E. 2001. Green fluorescent protein-tansgenic rat: A tool for organ transplantation research. Biochem. Biophys. Res. Commun. 286: 779-785.
6. Hammer, R.E., Maika, S.D., Richardson, J.A., Tang, J.P., and Taurog, J.D. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63: 1099-1112.
7. Hattori, K., Muta, M., Toi, M., Iizasa, H., Shinsei, M., Terasaki, T., Obinata, M., Ueda, M., and Nakashima, E. 2001. Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats. Pharm. Res. 18: 9-15.
8. Hirabayashi, M., Kato, M., Aoto, T., Sekimoto, A., Ueda, M., Miyoshi, I., Kasai, N., and Hochi, S. (in press). Offspring derived from intracytoplasmic injection of transgenic rat sperm. Transgenic Res. 10: in press.
9. Hirabayashi, M., Takahashi, R., Ito, K., Kodaira, K., Suzuki, T., and Ueda, M. 1997. Factors affecting the producing efficiency of transgenic rats. J. Reprod. Dev. 43: j15-j18.
10. Hosoya, K., Takashima, T., Tetsuka, K., Nagura, T., Ohtsuki, S., Takanaga, H., Ueda, M., Yanai, N., Obinata, M., and Terasaki, T. 2000. mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines: a new in vitro BBB model for drug targeting. J. Drug Targeting 8: 357-370.
11. Hosoya, K., Tomi, M., Ohtsuki, S., Takanaga, H., Ueda, M., Yanai, N., Obinata. M., and Terasaki, T. 2001. Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat. Exp. Eye. Res. 72: 163-172.
12. Kitazawa, T., Hosoya, K., Watanabe, M., Takashima, T., Ohtsuki, S., Takanaga, H., Ueda, M., Yanai, N., Obinata, M., and Terasaki, T. 2001. Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: A novel in vitro system for investigating transport functions at blood-cerebrospinal fluid barrer. Pharm. Res. 18: 16-22.
13. Jat, P.S. and Sharp, P.A. 1989. Cell lines established by a temperature-sensitive simian virus 40 large-T antigen are growth restricted at the non-permissive temperature. Mol. Cell. Biol. 9: 1672-1681.
14. b-tsA58 transgenic mouse. Proc. Natl. Acad. Sci. USA 88: 5096-5100.
15. Noble, M., Groves, A.K., Ataliotis, P., Ikram, Z., and Jat, P.S. 1995. The H-2Kb tsA58 transgenic mouse: a new tool for the rapid generation of novel cell lines. Transgenic Res. 4: 215-225.
16. Obinata, M. 1997. Conditionally immortalized cell lines with differentiated functions established from temperature-sensitive T-antigen transgenic mice. Genes to Cells 2: 235-244.
17. Palmiter, R.D., Chen, H.Y., Messing, A., and Brinster, R.L. 1985. SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumors. Nature 316: 457-460.
18. Takahashi, R., Hirabayashi, M., Yanai, N., Obinata, M., and Ueda, M. 1999. Establishment of SV40-tsA58 transgenic rats as a source of conditionally immortalized cell lines. Exp. Anim. 48: 255-261.
19. Terasaki, T. and Hosoya, K. 2001. Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions. Biol. Pharm. Bull. 24: 111-118.
20. Yanai, N., Suzuki, M., and Obinata, M. 1991. Hepatocyte cell lines established from transgenic mice harboring temperature-sensitive Simian Virus 40 large T-antigen gene. Exp. Cell Res. 197: 50-56.