Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer

Cancer Genetics and Cytogenetics

Volumn 134, Issue 1, 2002, Pages 46-54

  Planck, Maria ^a   Halvarsson, Britta ^a   Pålsson, Eva ^a   Hallén, Magnus ^a   Ekelund, Mats ^a   Pålsson, Birger ^a   Baldetorp, Bo ^a   Nilbert, Mef ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENESIS; CELL HETEROGENEITY; CHROMOSOME 12; CHROMOSOME 7; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; COLON CARCINOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOGENETICS; DIPLOIDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC STRAIN; GERM LINE; HUMAN; KARYOTYPE; MICROSATELLITE INSTABILITY; PHENOTYPE; PLOIDY; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR GROWTH;

CARRIER PROTEINS; CHROMOSOME ABERRATIONS; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MICROSATELLITE REPEATS; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PLOIDIES; REPETITIVE SEQUENCES, NUCLEIC ACID; TUMOR CELLS, CULTURED;

EID: 0036538849     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(01)00587-8     Document Type: Article

References (38)

1. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
2. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
3. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
4. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer
5. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
6. MLH3: A dna mismatch repair gene associated with mammalian microsatellite instability
7. Clues to the pathogenesis of familial colorectal cancer
8. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
9. Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
10. Genetic instability in colorectal cancers
11. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
12. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
13. Frameshift mutator mutations
14. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours
15. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
16. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability
17. Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability
18. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype
19. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients
20. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
21. A genetic model for colorectal tumorigenesis
22. Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer
23. Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: A study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR, and BLM genes
24. Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers
25. Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation
26. Regional reproducibility of microsatellite instability in sporadic colorectal cancer
27. Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity
28. HMLH1, hMSH2 and hMSH6 mutations in hereditary non-polyposis colorectal cancer families from southern Sweden
29. Typing of human papillomaviruses by polymerase chain reaction amplification with L1 consensus primers and RFLP analysis
30. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
31. Image cytometric DNA analysis in human breast cancer analysis may add prognostic information in diploid cases with low S-phase fraction by flow cytometry
32. New strategy for multi-colour flourescence in situ hybridisation: COBRA: COmbined Binary RAtio labelling
33. An update of HNPCC (Lynch syndrome)
34. Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry
35. DNA-repeat instability is associated with colorectal cancers presenting minimal chromosome rearrangements
36. Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients