High plasma levels of nitrogen oxides are associated with severe disease and correlate with rapid parasitological and clinical cure in Plasmodium falciparum malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 90, Issue 1, 1996, Pages 44-47

  Kremsner, Peter G ^a,b   Winkler, Stefan ^a,c   Wildling, Eckart ^a,c   Prada, Javier ^b   Bienzle, Ulrich ^b   Graninger, Wolfgang ^c   Nüssler, Andreas K ^d  

^a ALBERT SCHWEITZER HOSPITAL   (Gabon)

^b Institut fur Tropenmedizin   (Germany)

^c UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

C reactive protein; Malaria; Neopterin; Nitrate; Nitrite; Plasmodium falciparum

Indexed keywords

C REACTIVE PROTEIN; NEOPTERIN; NITRIC OXIDE; NITROGEN OXIDE;

ADOLESCENT; ADULT; ARTICLE; BLOOD LEVEL; CHILD; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 0030068778     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(96)90476-9     Document Type: Article

References (33)

1. Asensio, V. C., Oshima, H. & Falanga, P. B. (1993). Plasmodium berghei: is nitric oxide involved in the pathogenesis of mouse cerebral malaria? Experimental Parasitology, 77, 111-117.
2. Clark, I. A., Rockett, K. A. & Cowden, W. B. (1991). Proposed link between cytokines, nitric oxide and cerebral malaria. Parasitology Today, 7, 205-207.
3. Cot, S., Ringwald, P., Mulder, B., Miailhes, P., Yap-Yap, J., Nüssler, A. K. & Eling, M. C. (1994). Nitric oxide in cerebral malaria. Journal of Infectious Diseases, 169, 1417-1418.
4. Drapier, J. C., Wietzerbin, J. & Hibbs, J. B., jr (1988). Interferon-gamma and tumour necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. European Journal of Immunology, 18, 1587-1592.
5. Galve-De Rochemonteix, B., Wiktorowicz, K., Kushner, I. & Dayer, J. M. (1993). C-reactive protein increases production of IL-1α, IL-1β and TNFα, and expression of mRNA by human alveolar macrophages. Journal of Leukocyte Biology, 53, 439-445.
6. Graninger, W., Thalhammer, F., Hollenstein, U., Zotter, G. M. & Kremsner, P. G. (1992). Serum protein concentrations in Plasmodium falciparum malaria. Acta Tropica, 52, 121-128.
7. Grau, G. E., Tacchini-Cottier, F., Vesin, C., Milon, G., Lou, J. N., Piguet, P. F. & Juillard, P. (1993). TNF-induced microvascular pathology: active role of platelets and importance of the LFA-1/ICAM-1 interaction. European Cytokine Network, 4, 415-419.
8. G-monomethyl-L-arginine increases platelet deposition on damaged endothelium in vivo. A scanning electron microscopic study. Thrombocyte Research, 64, 1-9.
9. Kern, P., Hemmer, C. J., Van Damme, J., Gruss, H. J. & Dietrich, M. (1989). Elevated tumour necrosis factor alpha and interleukin 6 serum levels as markers for complicated Plasmodium falciparum malaria. American Journal of Medicine, 87, 139-143.
10. G-methyl-L-arginine inhibits tumour necrosis factor-induced hypotension. Proceedings of the National Academy of Sciences of the USA, 87, 3629-3632.
11. Kremsner, P. G., Feldmeier, H., Zotter, G. M., Jansen-Rosseck, R., Graninger, W., Rocha, R. M. & Bienzle, U. (1989). Immunological alterations in uncomplicated Plasmodiumfalciparum malaria. Relationship between parasitemia and indicators of macrophage activation. Acta Tropica, 46, 351-359.
12. Kremsner, P. G., Neifer, S., Ferreira-Chaves, M., Rudolph, R. & Bienzle, U. (1992). Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. European Journal of Immunology, 22, 2873-2878.
13. Kremsner, P. G., Winkler, S., Brandts, C., Graninger, W. & Bienzle, U. (1993a). Curing of chloroquine resistant malaria with clindamycin. American Journal of Tropical Medicine and Hygiene, 49, 650-654.
14. Kremsner, P. G., Nüssler, A. K., Neifer, S., Ferreira-Chaves, M., Bienzle, U., Senaldi, G. & Grau, G. E. (1993b). Malaria antigen and cytokine-induced production of reactive nitrogen intermediates by murine macrophages: no relevance to the development of experimental cerebral malaria. Immunology, 78, 286-290.
15. Kremsner, P. G., Winkler, S., Brandts, C., Neifer, S., Bienzle, U. & Graninger, W. (1994). Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon. Journal of Infectious Diseases, 169, 467-470.
16. Kubes, P., Suzuki, M. & Granger, D. N. (1991). Nitric oxide: an endogenous modulator of leukocyte adhesion. Proceedings of the National Academy of Sciences of the USA, 88, 4651-4655.
17. Leszczynski, D., Josephs, M. D. & Foegh, M. L. (1994). IL-1 beta-stimulated leucocyte-endothelial adhesion is regulated, in part, by the cyclic-GMP-dependent signal transduction pathway. Scandinavian Journal of Immunology, 39, 551-556.
18. Mellouk, S., Green, S. J., Nacy, C. A. & Hoffmann, S. L. (1991). IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine dependent effector mechanism. Journal of Immunology, 146, 3971-3976.
19. Naik, P. & Voller, A. (1984). Serum C-reactive protein levels and falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 78, 812-813.
20. Nüssler, A. K. & Billiar, T. R. (1993). Inflammation, immunoregulation, and inducible nitric oxide synthase. Journal of Leukocyte Biology, 54, 171-178.
21. Nüssler, A. K., Drapier, J. C., Renia, L., Pied, S., Miltgen, F., Gentilini, M. & Mazier, D. (1991). L-Arginine dependent destruction of intrahepatic malaria parasites in response to tumour necrosis factor and/or interleukin 6 stimulation. European Journal of Immunology, 21, 227-230.
22. Nüssler, A. K., Di Silvio, M., Billiar, T. R., Huffman, R., Geller, D., Selby, R., Madariaga, J. & Simmons, R. L. (1992). Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. Journal of Experimental Medicine, 176, 261-264.
23. Nüssler, A. K., Eling, W. & Kremsner, P. G. (1994). Patients with Plasmodium falciparum malaria and Plasmodium vivax malaria show increased nitrite and nitrate plasma levels. Journal of Infectious Diseases, 169, 1418-1419.
24. Ochoa, J. B., Udekwu, A. O., Billiar, T. R., Curran, R. D., Cerra, F. B., Simmons, R. L. & Peitzman, A. B. (1991). Nitrogen oxide levels in patients after trauma and during sepsis. Annals of Surgery, 214, 621-626.
25. Pied, S., Nüssler, A. K., Pontet, M., Miltgen, F., Matile, H., Lambert, P. H. & Mazier, D. (1989). C-reactive protein protects against preerythrocytic stages of malaria. Infection and Immunity, 57, 278-282.
26. Pongponratn, E., Riganti, M., Harinasuta, T. & Bunnag, D. (1985). Electron microscopy of the human brain in cerebral malaria. Southeast Asian Journal of Tropical Medicine and Public Health, 16, 219-227.
27. Radomski, M. W., Palmer, R. M. J. & Moncada, S. (1991). Modulation of platelet aggregation by an L-arginine nitric oxide pathway. Trends in Pharmacological Sciences, 12, 87-88.
28. Rockett, K. A., Awburn, M. M., Cowden, W. B. & Clark, I. A. (1991). Killing of Plasmodium falciparum in vitro by nitric oxide derivatives. Infection and Immunity, 59, 3280-3283.
29. Senaldi, G., Kremsner, P. G. & Grau, G. E. (1992). Nitric oxide and cerebral malaria. Lancet, 340, 1554.
30. Stuehr, D. J. & Marietta, M. A. (1987). Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines or interferon-gamma. Journal of Immunology, 139, 518-525.
31. Vidal, M. J., Zocchi, M. R., Poggi, A., Pellegatta, F. & Chierchia, S. L. (1992). Involvement of nitric oxide in tumour cell adhesion to cytokine-activated endothelial cells. Journal of Cardiovascular Pharmacology, 20, supplement 12, S155-S159.
32. Warrell, D. A., Molyneux, M. E. & Beales, P. F., editors (1990). Severe and complicated malaria, 2nd edition. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, supplement 2.
33. Wildling, E., Winkler, S., Kremsner, P. G., Brandts, C., Jenne, L. & Wernsdorfer, W. H. (1995). Malaria epidemiology in the province of Moyen Ogooué, Gabon. Tropical Medicine and Parasitology. 46, 77-82.