The consequences of hydroxyl radical formation on the stoichiometry and kinetics of ferrous iron oxidation by human apoferritin

Free Radical Biology and Medicine

Volumn 31, Issue 8, 2001, Pages 1007-1017

  Van Eden, Marc E ^a   Aust, Steven D ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Ferritin; Ferroxidase; Free radicals; Hydroxyl radical; Oxidative protein damage

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; APOFERRITIN; FERROUS ION; HYDROXYL RADICAL; PROTEIN SUBUNIT; SODIUM CHLORIDE;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; KINETICS; OXIDATION; PH; PRIORITY JOURNAL; STOICHIOMETRY;

APOFERRITINS; CERULOPLASMIN; ENZYME ACTIVATION; FERRIC COMPOUNDS; FREE RADICALS; HEPES; HUMANS; HYDROXYL RADICAL; IRON; KINETICS; OXIDATION-REDUCTION; PROTEIN BINDING; RECOMBINANT PROTEINS; SPLEEN;

EID: 0035887746     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00677-3     Document Type: Article

References (63)

1. Ferritin: Structure, gene regulation, and cellular function in animals, plants and microorganisms
2. The ferritins: Molecular properties, iron storage function and cellular regulation
3. The magnetic properties of ferritin and some other colloidal ferric compounds
4. Relationship between iron and phosphate in mammalian ferritins
5. On ferritin heterogeneity. Further evidence for heteropolymers
6. Fate of oxygen during ferritin iron incorporation
7. Variable stoichiometry of Fe(II)-oxidation in ferritin
8. Stoichiometry of iron oxidation by apoferritin
9. Iron oxidation chemistry in ferritin. Increasing Fe/O2 stoichiometry during core formation
10. Reaction paths of iron oxidation and hydrolysis in horse spleen and recombinant human ferritins
11. Iron incorporation into ferritins: Evidence for the transfer of monomeric Fe(III) between ferritin molecules and for the formation of an unusual mineral in the ferritin of Escherichia coli
12. Mössbauer spectroscopic investigation of structure-function relations in ferritins
13. Iron (II) oxidation and early intermediates of iron-core formation in recombinant human H-chain ferritin
14. The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake
15. The formation of ferritin from apoferritin. Catalytic action of apoferritin
16. The catalytic activity of horse spleen apoferritin. Preliminary kinetic studies and the effect of chemical modification
17. A mechanism for ferritin-iron oxidation and deposition
18. Transition metals as catalysts of "autoxidation" reactions
19. Iron and oxygen: A dangerous mixture
20. The catalytic decomposition of hydrogen peroxide by iron salts
21. The paradox of oxygen: Thermodynamics versus toxicity
22. Oxygen toxicity, oxygen radicals, transition metals and disease
23. Hydroxyl radical production during oxidative deposition of iron in ferritin
24. Adaptive responses of rat tissue isoferritins to iron administration. Changes in subunit synthesis, isoferritin abundance, and capacity for iron storage
25. Intact human ceruloplasmin is required for the incorporation of iron into human ferritin
26. Production of recombinant human apoferritin heteromers
27. Expression and loading of recombinant heavy and light chain homopolymers of rat liver ferritin
28. Kinetic analysis of progress curves
29. Considerations in the spin trapping of superoxide and hydroxyl radical in aqueous systems using 5,5-dimethyl-1-pyrroline-N-oxide
30. ESR spin trapping studies into the nature of the oxidizing species formed in the Fenton reaction: Pitfalls associated with the use of 5,5-dimethyl-1-pyrroline-N-oxide in the detection of the hydroxyl radical
31. The spin trapping of superoxide and hydroxyl free radicals with DMPO (5,5-dimethyl-1-pyrroline-N-oxide): More about iron
32. Radicals from "Good's" buffers
33. Stoichiometry of Fe(II) oxidation during ceruloplasmin-catalyzed loading of ferritin
34. Hydrogen ion buffers for biological research
35. Implications for in vitro studies of the autoxidation of ferrous ion and the iron-catalyzed autoxidation of dithiothreitol
36. The autoxidation of iron(II) in aqueous systems: The effects of iron chelation by physiological, non-physiological and therapeutic chelators on the generation of reactive oxygen species and the inducement of biomolecular damage
37. Mobilization of iron from ferritin fractions of defined iron content by biological reductants
38. Mobilization of ferritin iron by chelators in vitro
39. Heterogeneity in horse ferritins. A comparative study of surface charge, iron content and kinetics of iron uptake
40. Ferroxidase activity of ferritin: Effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation
41. An investigation into the role of hydroxyl radical in xanthine oxidase-dependent lipid peroxidation
42. The multiple effects of ethylenediaminetetraacetate in several model lipid peroxidation systems
43. Ferroxidase kinetics of human liver apoferritin, recombinant H-chain apoferritin, and site-directed mutants
44. Degradation of oxidized proteins in mammalian cells
45. Metal-catalyzed oxidation of proteins. Physiological consequences
46. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
47. When do metal complexes protect the biological system from superoxide toxicity and when do they enhance it?
48. In vitro loading of apoferritin
49. Modification of ferritin during iron loading
50. Facilitation of Fe(II) autoxidation by Fe(III) complexing agents
51. 3
52. The contribution of citrate to the ferroxidase activity of serum
53. Transient overexpression of human H- and L-ferritin chains in COS cells
54. Expression and structural and functional properties of human ferritin L-chain from Escherichia coli
55. Purification and characterization of Fet3 protein, a yeast homologue of ceruloplasmin
56. Ceruloplasmin
57. The expression of genes coding for positive acute-phase proteins in the reproductive tract of the female rat. High levels of ceruloplasmin mRNA in the uterus
58. Sertoli cells synthesize and secrete a ceruloplasmin-like protein
59. Characterization, mapping, and expression of the human ceruloplasmin gene
60. A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes
61. Iron loading into ferritin by an intracellular ferroxidase