High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: Evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis

Cancer Research

Volumn 62, Issue 7, 2002, Pages 1952-1955

  Lott, Steven T ^a   Chandler, Dawn S ^a   Curley, Steven A ^a   Foster, Carolyn J ^a   El Naggar, Adel ^a   Frazier, Marsha ^a   Strong, Louise C ^a   Lovell, Mercedes ^a   Killary, Ann McNeill ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1;

ARTICLE; CANCER MODEL; CARCINOGENESIS; CHROMOSOME 3P; GENE LOCUS; GENE MAPPING; GENETIC PREDISPOSITION; GENOTYPE; GERM LINE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CARCINOMA; MALIGNANT TRANSFORMATION; PANCREAS ISLET CELL TUMOR; PHENOTYPE; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; VON HIPPEL LINDAU DISEASE;

ADENOMA, ISLET CELL; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 3; FEMALE; HIPPEL-LINDAU DISEASE; HUMANS; LIGASES; LOSS OF HETEROZYGOSITY; MALE; MUTATION, MISSENSE; PANCREATIC NEOPLASMS; PEDIGREE; RETROSPECTIVE STUDIES; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0036532047     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

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2. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
3. The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
4. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
5. Molecular genetics of human renal cell tumors
6. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
7. Vascular tumors in livers associated with targeted inactivation of the von Hippel-Lindau tumor suppressor
8. Involvement of multiple loci on chromosome 3 in renal cell cancer development
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10. Physical and functional mapping of a tumor suppressor locus for renal cell carcinoma within chromosome 3p12
11. The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation
12. A method to isolate DNA from small archival tissue samples for p53 gene analysis
13. Mutations of the VHL tumour suppressor gene in renal carcinoma
14. Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors
15. Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease: Analysis of allele loss in VHL tumors
16. Pancreatic lesions in von Hippel-Lindau disease: Prevalence, clinical significance, and CT findings
17. Homozygous deletions of human chromosome 3p in lung tumors
18. Homozygous deletions at 3p12 in breast and lung cancer
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20. Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumors
21. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
22. Induction of angiogenesis during the transition from hyperplasia to neoplasia
23. Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
24. The candidate tumor suppressor gene, RASSFIA, from human chromosome 3p21.3 is involved in kidney tumorigenesis
25. Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Duttl/Robol gene