Measuring the complexity of cell cycle arrest and killing of drugs: Kinetics of phase-specific effects induced by taxol

Cytometry

Volumn 37, Issue 2, 1999, Pages 113-124

  Sena, Giovanni ^a   Onado, Carlo ^a   Cappella, Paolo ^a   Montalenti, Francesco ^a   Ubezio, Paolo ^a,b  

^a Biophysics Unit   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Apoptosis; Cell cycle; Cell proliferation; Chemotherapy; Flow cytometry; Mathematical models; Taxol

Indexed keywords

PACLITAXEL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; CHEMOTHERAPY; COMPUTER PROGRAM; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; KINETICS; MATHEMATICAL MODEL; MITOSIS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL DIVISION; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; HISTOCYTOCHEMISTRY; HUMANS; IN SITU NICK-END LABELING; INTERPHASE; MITOSIS; PACLITAXEL; S PHASE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0033215008     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0320(19991001)37:2<113::AID-CYTO4>3.0.CO;2-M     Document Type: Article

References (24)

1. Cook JA, Mitchell JB. Viability measurements in mammalian cell systems. Analytical Biochem 1989;179:1-7.
2. Lamb JR, Friend SH. Which guesstimate is the best guesstimate? Predicting chemotherapeutic outcomes. Nature (Medicine) 1997;3:962-963.
3. Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B, Williams J. Cell-cycle arrest versus cell death in cancer therapy. Nature (Medicine) 1997;3:1034-1036.
4. Ubezio P. Relationship between flow cytometric data and kinetic parameters. Eur J Histochem 1993;37:15-28.
5. Rowinsky EK, Donehower RC, Jones RJ, Tucker RW. Microtubule changes and cytotoxicity in leukemic cell lines treated with Taxol. Cancer Res 1988;80:4093-4096.
6. Schiff PB, Horwitz SB. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci USA 1980;77:1561-1565.
7. Lopes NM, Adams EG, Pitts TW, Bhuyan BK. Cell kill kinetics and cell cycle effects of Taxol on human and hamster ovarian cell lines. Cancer Chemother Pharmacol 1993;32:235-242.
8. Woods CM, Zhu J, McQueney PA, Bollag D, Lazarides E. Taxol-Induced mitotic block trigger rapid onset of a p53-independent apoptotic pathway. Mol Med 1995;1:1076-1551.
9. Eisenhauer EA, ten Bokkel Huinink WW, Swenerton KD, Gianni L, Myles J, van der Burg ME, Kerr I, Vermorken JB, Buser K, Colombo N, et al. European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion. J Clin Oncol 1994;12:2654-2666.
10. Holmes FA. Paclitaxel combination therapy in the treatment of metastatic breast cancer: a review. Sem Oncol 1996;23:46-56.
11. Donaldson KL, Goolsby GL, Wahl AF. Cytotoxicity of the anticancer agents cisplatin and Taxol during cell proliferation and the cell cycle, Int J Cancer 1994;57:847-855.
12. Hennequin C, Giocanti N, Favaudon V. S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells. Br J Cancer 1995;71:1194-1198.
13. Dolbeare F, Gratzner H, Pallavicini MG, Gray JW. Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc Natl Acad Sci USA 1983;80:5573-5577.
14. Ubezio P, Filippeschi S, Spinelli L. Method for kinetic analysis of drug-induced cell cycle perturbations. Cytometry 1991;12:119-126.
15. Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 1993;53:1945-1951.
16. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 1997;27:1-20.
17. Ubezio P. Cell cycle simulation for flow Cytometry. Comput Meth Programs Biomed 1990;31:255-266.
18. Ubezio P, Rossotti A. Sensitivity of flow cytometric data to variation in cell cycle parameters. Cell Tissue Kinet 1987;20:507-517.
19. Priori L, Ubezio P. Mathematical modelling and computer simulation of cell synchrony. Meth Cell Sci 1996;18:83-91.
20. Montalenti F, Sena G, Cappella P, Ubezio U. Simulating cancer-cell kinetics after drug treatment: Application to cisplatin on ovarian carcinoma. Phys Rev E 1998;57:5877-5887.
21. Gianni L, Kearns CM, Giani A, Capri G, Vigano L, Lotatelli A, Bonadonna G, Egorin MJ. Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/ pharmacodynamic relationship in human. J Clin Oncol 1995;13:180-190.
22. Huizing MT, Keung ACF, Rosing H, Van der Kuij V, Bokkel Huinink WW, Mandjes IM, Dubbelman AC, Pinedo HM, Beijnen JH. Pharmacokinetics of paclitaxel and metabolites in randomized comparative study in platinum-pretreated ovarian cancer patients. J Clin Oncol 1993;11:2127-2135.
23. Trielli MO, Andreassen PR, Lacroix FB, Morgolis RL. Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells. J Cell Biol 1996;135:689-700.
24. Roberts JR, Allison DC, Donehower RC, Rowinski ER. Development of polyploidization in Taxol-resistant human leukemia cells in vitro. Cancer Res 1990;50:710-716.