Development of solubility screening methods in drug discovery

Yakugaku Zasshi

Volumn 122, Issue 3, 2002, Pages 237-246

  Sugaya, Yukiko ^a   Yoshiba, Takako ^a   Kajima, Takashi ^a   Ishihama, Yasushi ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Drug discovery; High throughput screening; Powder dissolution; Solubility screening; Solution precipitation

Indexed keywords

ACETIC ACID DERIVATIVE; BENZBROMARONE; BUFFER; CYCLANDELATE; DIMETHYL SULFOXIDE; DIPYRIDAMOLE; FLUFENAMIC ACID; FLUOROCORTISONE ACETATE; FLURBIPROFEN; FUROSEMIDE; HYDROXYZINE EMBONATE; IBUPROFEN; KETOCONAZOLE; KETOPROFEN; NAPROXEN; OXYPHENBUTAZONE; PHENYLBUTAZONE; PHENYTOIN; RESERPINE; SALICYLIC ACID DERIVATIVE; SALOL; SULINDAC; TAMOXIFEN; TERFENADINE; TESTOSTERONE; TOLBUTAMIDE; TRICHLORMETHIAZIDE; UNCLASSIFIED DRUG; DRUG;

ANTENNA; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DRUG SCREENING; DRUG SOLUBILITY; FILTER; FILTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; MEMBRANE; MOLECULAR INTERACTION; POWDER DISSOLUTION METHOD; SAMPLER; SAMPLING; SOLID STATE; SOLUTION PRECIPITATION METHOD; SOLVATION; TECHNIQUE; CHEMISTRY; DRUG DESIGN; INSTRUMENTATION; METHODOLOGY; PHYSICAL CHEMISTRY; SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMETHYL SULFOXIDE; DRUG DESIGN; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 0036515918     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi.122.237     Document Type: Article

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