High-resolution nuclear magnetic resonance applied to biophysics and molecular biology: Highlights and challenges

IEEE Transactions on Applied Superconductivity

Volumn 12, Issue 1, 2002, Pages 740-745

  Wider, Gerhard ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Drug design; NMR spectrometer; Polypeptide; Protein structure; Superconducting magnets; TROSY

Indexed keywords

BIOCHEMISTRY; BIOMEDICAL ENGINEERING; DRUG PRODUCTS; MACROMOLECULES; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYPEPTIDES; PROTEINS; SPECTROMETERS;

BIOPHYSICS; DRUG DESIGN; DRUG DISCOVERY; NUCLEAR MAGNETIC RESONANCE SPECTROMETER; PROTEIN STRUCTURE; STRUCTURAL BIOLOGY; TRANSVERSE RELAXATION OPTIMIZED SPECTROSCOPY;

SUPERCONDUCTING MAGNETS;

EID: 0036509606     PISSN: 10518223     EISSN: None     Source Type: Journal    
DOI: 10.1109/TASC.2002.1018508     Document Type: Conference Paper

References (28)

1. Sequential resonance assignments as a basis for determination of spatial protein structures by high resolution proton nuclear magnetic resonance
2. Structure determination of biological macromolecules in solution using NMR spectroscopy
3. Insights into protein folding from NMR
4. Probing molecular motion by NMR
5. Protein dynamics from NMR
6. Technical aspects of NMR spectroscopy with biological macromolecules and studies of hydration in solution
7. SAR by NMR: A method for discovering high affinity ligands for proteins
8. Structure of the urea unfolded 434 repressor determined by NMR in solution
9. Methodological advances in protein NMR
10. 2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution
11. Impact of transverse relaxation optimized spectroscopy (TROSY) on NMR as a technique in structural biology
12. NMR assignment and secondary structure determination of an octameric 110 kDa protein using TROSY in triple resonance experiments
13. NMR spectroscopy of large molecules and multimolecular assemblies in solution
14. 1H NMR of proteins. Experimental procedures
15. The protein data bank: A computer-based archival file for macromolecular structures
16. 1H nuclear magnetic resonance and distance geometry
17. The use of H-2, C-13, N-15 multidimensional NMR to study the structure and dynamics of proteins
18. Structure calculation of biological macromolecules from NMR data
19. 13C nuclear-magnetic-resonance chemical-shifts
20. NC scalar couplings
21. Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium
22. New techniques in structural NMR-anisotropic interactions
23. NMR solution structure of the human prion protein
24. Extending the size limit of protein nuclear magnetic resonance
25. TROSY in triple-resonance experiments: New perspectives for sequential NMR assignment of large proteins
26. 1H]-ZQ-TROSY NMR experiment with diagonal peak suppression