Comparison of in vitro BBMEC permeability and in vivo CNS uptake by microdialysis sampling

Journal of Pharmaceutical and Biomedical Analysis

Volumn 27, Issue 6, 2002, Pages 945-958

  Hansen, D K ^a   Scott, D O ^b   Otis, K W ^a   Lunte, S M ^c  

^a IQVIA   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

BBMEC permeability; CNS uptake; Microdialysis sampling

Indexed keywords

CAFFEINE; KYNURENIC ACID; MANNITOL; TRYPTOPHAN;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN METABOLISM; CALIBRATION; CELL TRANSPORT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG ADSORPTION; DRUG PENETRATION; DRUG UPTAKE; ENDOTHELIUM CELL; EXTRACELLULAR FLUID; EXTRACELLULAR SPACE; IN VITRO STUDY; IN VIVO STUDY; MALE; MATHEMATICAL MODEL; MICRODIALYSIS; NONHUMAN; PERMEABILITY; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; PREDICTION; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CATTLE; ENDOTHELIUM, VASCULAR; EXTRACELLULAR SPACE; MALE; MICRODIALYSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036498117     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(01)00542-8     Document Type: Article

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