Hepatic cytochrome P450 and flavin-containing monooxygenase in male Nts:Mini rat, a transgenic rat carrying antisense RNA transgene for rat growth hormone

Toxicology Letters

Volumn 106, Issue 2-3, 1999, Pages 159-169

  Tani, Yoshiro ^a,b   Yamamoto, Hideki ^a   Kawaji, Akiko ^c   Mizuno, Hatsue ^a   Fukushige, Junichiro ^a   Hosokawa, Tsunemichi ^a   Doi, Kunio ^b  

^a DAIICHI SANKYO CO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Kinki University   (Japan)

Author keywords

Cytochrome P450; Flavin containing monooxygenase; Growth hormone deficiency; Liver microsome; Mini rats

Indexed keywords

COMPLEMENTARY RNA; CYTOCHROME P450 ISOENZYME; DIMETHYLANILINE MONOOXYGENASE; GLUTATHIONE; GROWTH HORMONE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GROWTH HORMONE DEFICIENCY; IMMUNOBLOTTING; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOTTING, WESTERN; CYTOCHROME P-450 ENZYME SYSTEM; GROWTH HORMONE; MALE; MICROSOMES, LIVER; OXYGENASES; RATS; RATS, WISTAR; RNA, ANTISENSE; TRANSGENES;

RATTUS NORVEGICUS;

EID: 0033030393     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00055-7     Document Type: Article

References (44)

1. Baldock G.A., Brodie R.R., Chasseaud L.F., Taylor T. Determination of benzydamine and its N-oxide in biological fluids by high-performance liquid chromatography. J. Chromatogr. 529:1990;113-123.
2. Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., Mayer R.T. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues. A series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34:1985;3337-3345.
3. Clark M.A., Bing B.A., Gottschall P.E., Williams J.F. Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes. Biochem. Pharmacol. 49:1995;97-104.
4. Coon M.J., Vaz A.D.N., Bestervelt L.L. Peroxidative reactions of diversozymes. FASEB J. 10:1996;428-434.
5. Cooper J.R., Brodie B.B. The enzymatic metabolism of hexobarbital (EVIPAL). J. Pharmacol. Exp. Ther. 114:1955;409-417.
6. Damani L.A., Nnane I.P. The assessment of flavin-containing monooxygenase activity in intact animals. Drug Metab. Drug Interact. 13:1996;1-28.
7. 4-steroid 5α-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450. J. Biol. Chem. 261:1986;10728-10735.
8. Guengerich F.P., Wang P., Davidson N.K. Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry. 21:1982;1698-1706.
9. Hong J.Y., Ning S.M., Ma B.L., Lee M.J., Pan J.M., Yang C.S. Roles of pituitary hormones in the regulation of hepatic cytochrome P450IIE1 in rats and mice. Arch. Biochem. Biophys. 281:1990;132-138.
10. Imaoka S., Inoue T., Funae Y. Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography. Arch. Biochem. Biophys. 265:1988;159-170.
11. Imaoka S., Fujita S., Funae Y. Age-dependent expression of cytochrome P-450s in rat liver. Biochim. Biophys. Acta. 1097:1991;187-192.
12. Kawaji A., Ohara K., Takabatake E. An assay of flavin-containing monooxygenase activity with benzydamine N-oxidation. Anal. Biochem. 214:1993;409-412.
13. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
14. Lawton M.P., Cashman J.R., Cresteil T., Dolphin C.T., Elfarra A.A., Hines R.N., Hodgson E., Kimura T., Ozols J., Phillips I.R., Philpot R.M., Poulsen L.L., Rettie A.E., Shephard E.A., Williams D.E., Ziegler D.M. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. Arch. Biochem. Biophys. 308:1994;254-257.
15. Lemoine A., Williams D.E., Cresteil T., Leroux J.-P. Hormonal regulation of microsomal flavin-containing monooxygenase: tissue-dependent expression and substrate specificity. Mol. Pharmacol. 40:1991;211-217.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. Matsumoto K., Kakidani H., Takahashi A., Nakagata N., Anzai M., Matsuzaki Y., Takahashi Y., Miyata K., Utsumi K., Iritani A. Growth retardation in rats whose growth hormone gene expression was suppressed by antisense RNA transgene. Mol. Reprod. Dev. 36:1993;53-58.
18. Matsumoto K., Kakidani H., Anzai M., Nakagata N., Takahashi A., Takahashi Y., Miyata K. Evaluation of an antisense RNA transgene for inhibiting growth hormone gene expression in transgenic rats. Dev. Genet. 16:1995;273-277.
19. Morgan E.T., MacGeoch C., Gustafsson J.Å. Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16α-hydroxylase cytochrome P-450 apoprotein in the rat. J. Biol. Chem. 260:1985;11895-11898.
20. Moroni P., Longin-Sauvageon C., Benoit E. The flavin-containing monooxygenases in rat liver: evidence for the expression of a second form different from FMO1. Biochem. Biophys. Res. Commun. 212:1995;820-826.
21. Murayama N, Shimada M., Yamazoe Y., Kato R. Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system. Mol. Pharmacol. 39:1991;811-817.
22. Nash T. The calorimetric estimation of formaldehyde by means of the Hantzsch reaction. J. Biol. Chem. 55:1953;416-422.
23. Oinonen T., Lindros K.O. Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver. Biochem. J. 309:1995;55-61.
24. Omura T., Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239:1964;2370-2378.
25. Pampori N.A., Shapiro B.H. Over-expression of CYP2C11, the major male-specific form of hepatic cytochrome P450, in the presence of nominal pulses of circulating growth hormone in adult male rats neonatally exposed to low levels of monosodium glutamate. J. Pharmacol. Exp. Ther. 271:1994;1067-1073.
26. Pampori N.A., Agrawal A.K., Waxman D.J., Shapiro B.H. Differential effects of neonatally administered glutamate on the ultradian pattern of circulating growth hormone regulating expression of sex-dependent forms of cytochrome P450. Biochem. Pharmacol. 41:1991;1299-1309.
27. 5. Arch. Biochem. Biophys. 251:1986;629-638.
28. Sato C., Matsuda Y., Lieber C.S. Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat. Gastroenterology. 80:1981;140-148.
29. Shimada M., Murayama N., Yamazoe Y., Hashimoto H., Ishikawa H., Kato R. Age- and sex-related alterations of microsomal drug- and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats. J. Pharmacol. Exp. Ther. 275:1995;972-977.
30. Shimada M., Murayama N., Nagata K., Hashimoto H., Ishikawa H., Yamazoe Y. A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats: reversal of the profiles by growth hormone-treatment. Arch. Biochem. Biophys. 337:1997;34-42.
31. Song B.J., Gelboin H.V., Park S.S., Yang C.S., Gonzalez F.J. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. J. Biol. Chem. 261:1986;16689-16697.
32. Tani Y., Murata S., Kajiwara S., Mizuno H., Fukushige J., Hosokawa T., Uetsuka K., Nakayama H., Doi K. Rapid induction of liver cirrhosis in Mini rats by thioacetamide. J. Toxicol. Pathol. 11:1998;119-125.
33. Teranishi M., Tani Y., Manabe S. Comparison of age-related bone changes between Mini rats and Wistar rats. J. Toxicol. Pathol. 11:1998;137-143.
34. Towbin H., Staehlin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
35. Uetsuka K., Suzuki M., Nakayama H., Doi K. Immunohistochemical study on galactosamine-induced subacute hepatitis in rats of Jcl:Wistar-TgN(ARGHGEN)1Nts strain (Mini rats). Exp. Anim. 46:1997;203-209.
36. Watkins J.B., Sanders R.A., Beck L.V. The effect of long-term streptozotocin-induced diabetes on the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats. Toxicol. Appl. Pharmacol. 93:1988;329-338.
37. Waxman D.J., Walsh C. Phenobarbital-induced rat liver cytochrome P-450. J. Biol. Chem. 256:1982;1044-1052.
38. Waxman D.J., Ram P.A., Pampori N.A., Shapiro B.H. Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. Mol. Pharmacol. 48:1995;790-797.
39. Wells T., Mode A., Floby E., Robinson I.C. The sensitivity of hepatic CYP2C gene expression to baseline growth hormone (GH) bioactivity in dwarf rats: effects of GH-binding protein in vivo. Endocrinology. 134:1994;2135-2141.
40. Yamazoe Y., Shimada M., Murayama N., Kato R. Suppression of levels of phenobarbital-induced rat liver cytochrome P-450 by pituitary hormone. J. Biol. Chem. 262:1987;7423-7428.
41. Yamazoe Y., Shimada M., Murayama N., Yamauchi K., Kato R. Alteration of hepatic drug metabolizing activities and contents of cytochrome P-450 isozymes by neonatal monosodium glutamate treatment. Biochem. Pharmacol. 37:1988;1687-1691.
42. Yamazoe Y., Murayama N., Shimada M., Kato R. Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e and other neonatal P-450s in hypophysectomized rats. Biochem. Biophys. Res. Commun. 160:1989;609-614.
43. Yamazoe Y., Murayama N., Shimada M., Imaoka S., Funae Y., Kato R. Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes. Mol. Pharmacol. 36:1989;716-722.
44. Ziegler D.M. Flavin-containing monooxygenases: catalytic mechanism and substrate specificities. Drug Metab. Rev. 19:1988;1-32.