Pharmacogenetics: Ethical issues and policy options

Kennedy Institute of Ethics Journal

Volumn 12, Issue 1, 2002, Pages 1-15

  Buchanan, Allen ^a   Califano, Andrea ^a   Kahn, Jeffrey ^a   McPherson, Elizabeth ^a   Robertson, John ^a   Brody, Baruch ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOMEDICAL AND BEHAVIORAL RESEARCH; CONFIDENTIALITY; DRUG INDUSTRY; FOOD AND DRUG ADMINISTRATION; GENETIC PRIVACY; GENETIC SCREENING; GENETIC VARIABILITY; GENETICS; GENETICS AND REPRODUCTION; GOVERNMENT REGULATION; HEALTH INSURANCE; HUMAN; INFORMED CONSENT; LEGAL ASPECT; PHARMACOGENETICS; PHYSICIAN ATTITUDE; POLICY; RISK ASSESSMENT; UNITED STATES;

BIOMEDICAL AND BEHAVIORAL RESEARCH; GENETICS AND REPRODUCTION;

CONFIDENTIALITY; DRUG INDUSTRY; GENETIC PRIVACY; GENETIC RESEARCH; GENETIC SCREENING; GOVERNMENT REGULATION; HUMANS; INFORMED CONSENT; INSURANCE, HEALTH; PHARMACOGENETICS; PHYSICIAN'S ROLE; PUBLIC POLICY; RISK ASSESSMENT; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; VARIATION (GENETICS);

EID: 0036490808     PISSN: 10546863     EISSN: None     Source Type: Journal    
DOI: 10.1353/ken.2002.0001     Document Type: Article

References (20)

1. Beaudet, Arthur L. 1999. ASGH Presidential Address. Making Genomic Medicine a Reality. American Journal of Human Genetics. 64: 1-13.
2. Bootman, J. Lyle; Townsend, Raymond J.; and McGhan, William F. 1996. Principles of Pharmacoeconoinics. 2d ed. Cincinnati, OH: Harvey Whitney Books Co.
3. Brock, Dan W. 1983. Distribution of Health Care and Individual Liberty. In Securing Access to Health Care, Volume Two: Appendices (Sociocultural and Philosophical Studies), President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, pp. 239-63. Washington, DC: U.S. Government Printing Office.
4. Califano, Andrea; Stolovitzky, Gustavo; and Tu, Yuhai 2000. Analysis of Gene Expression Microarrays for Phenotype Classification. In Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology, ed. Philip Bourne; Michael Gribskov; Russ Altman; et al., pp. 75-85. Menlo Park, CA: AAAI Press.
5. Collins, Francis S. 1999. Shattuck Lecture - Medical and Societal Consequences of the Human Genome Project. New England Journal of Medicine 341: 28-37.
6. Daniels, Norman; Light, Donald W.; and Caplan, Ronald L., eds. 1996. Benchmarks of Fairness for Health Care Reform. New York: Oxford University Press.
7. DHHS. Department of Health and Human Services. 2000. Standards for Privacy of Individually Identifiable Health Information. Federal Register 65 (28 December): 82462.
8. Drazen, Jeffrey M.; Yandava, Chandri N.; Dubé, Louise; et al. 1999. Pharmacogenetic Association Between ALOX5 Promoter Genotype and the Response to Anti-Asthma Treatment. Nature Genetics. 22: 168-70.
9. Giardiello, Francis M.; Brensinger, Jill D.; Petersen, Gloria M.; et al. 1997. The Use and Interpretation of Commercial APC Gene Testing for Familial Adenomatous Polyposis. New England Journal of Medicine 336: 823-27.
10. Hall, Mark A., and Rich, Stephen S. 2000. Patients' Fear of Genetic Discrimination by Health Insurers: The Impact of Legal Protections. Genetics in Medicine 2: 214-21.
11. Murphy, M. Paul; Beaman, Margaret E.; Clark, L. Scott; et al. 2000. Prospective CYP2D6 Genotyping as an Exclusion Criterion for Enrollment of a Phase III Clinical Trial. Pharmacogenetics 10: 583-90.
12. NBAC. National Bioethics Advisory Commission. 1999. Research Involving Human Biological Materials: Ethical Issues and Policy Guidance. Rockville, MD: NBAC.
13. Roses, Allen D. 1997. Genetic Testing for Alzheimer Disease. Practical and Ethical Issues. Archives of Neurology 54: 1226-29.
14. _. 2000a. Pharmacogenetics and Future Drug Development and Delivery. Lancet 355: 1358-61.
15. _. 2000b. Pharmacogenetics and the Practice of Medicine. Nature 405: 857-65.
16. Sander, Chris. 2000. Genomic Medicine and the Future of Health Care. Science 287: 1977-78.
17. Secretary's Advisory Committee on Genetic Testing. 2001. Enhancing the Oversight of Genetic Tests: Recommendations of the SACGT. (Available at http://www4.od.nih.gov/oba/sacgt.htm. Accessed 30 April 2001.)
18. Sykes, Richard. 2000. New Medicines, the Practice of Medicine, and Public Policy: A Strategic View of How Innovation in the Development of Medicine Will Impact on the Practice of Medicine and the Delivery of Healthcare During the Next Two Decades. Norwich: Stationery Office.
19. Weinstein, John N. 2000. Pharmacogenomics - Teaching Old Drugs New Tricks. New England Journal of Medicine 343: 1408-9.
20. _; Myers, Timothy G.; O'Connor, Patrick M.; et al. 1997. An Information-Intensive Approach to the Molecular Pharmacology of Cancer. Science 275: 343-49.