Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice

Life Sciences

Volumn 70, Issue 15, 2002, Pages 1727-1740

  Nemmani, Kumar V S ^a   Ramarao, P ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Analgesia; Benzodiazepine GABAA receptor complex; Diazepam; Ginseng total saponin; Kappa opioid agonist; Tolerance

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BICUCULLINE; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; DIAZEPAM; FLUMAZENIL; GINSENG SAPONIN; KAPPA OPIATE RECEPTOR AGONIST; NALOXONE H 3; PICROTOXIN; UNCLASSIFIED DRUG; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ANALGESIC AGENT; GINSENOSIDE; HERBACEOUS AGENT; KAPPA OPIATE RECEPTOR; SAPONIN;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ATTENUATION; BRAIN MEMBRANE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG TOLERANCE; MALE; MOUSE; NONHUMAN; TAIL FLICK TEST; ANIMAL; DRUG POTENTIATION; GINSENG; INTRAPERITONEAL DRUG ADMINISTRATION; PAIN; PAIN THRESHOLD; PHYSIOLOGY; TAIL;

PANAX GINSENG;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, NON-NARCOTIC; ANIMALS; BICUCULLINE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ANTAGONISM; DRUG TOLERANCE; DRUGS, CHINESE HERBAL; FLUMAZENIL; GINSENOSIDES; INJECTIONS, INTRAPERITONEAL; MALE; MICE; PAIN; PAIN THRESHOLD; PANAX; PICROTOXIN; RECEPTORS, GABA-A; RECEPTORS, OPIOID, KAPPA; SAPONINS; TAIL;

EID: 0036489195     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01496-0     Document Type: Article

References (35)

1. Ginseng pharmacology: Multiple constituents and multiple actions
2. Modulatory role of ginsenosides injected intrathecally or intracerebroventrically in the production of antinociception induced by kappa-opioid receptor agonist administered intracerebroventrically in the mouse
3. Attenuation of U-50,488H-induced antinociception by ginseng total saponins is dependent on serotonergic mechanisms
4. Evidence that ginsenosides prevent the development of opioid tolerance at the central nervous system
5. Effects of Panax ginseng on the development of morphine tolerance and dependence
6. The effect of Panax ginseng on the development of tolerance to the pharmacological actions of morphine in the rat
7. Effect of ginseng saponins on U-50,488H analgesia and its tolerance to analgesia in mice
8. The effect of benzodiazepines on the analgesic activity of morphine and sodium salicylate
9. Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam
10. The possible role of benzodiazepine receptors in morphine analgesia
11. Majonoside-R2, a major constituent of Vietnamese ginseng, attenuates opioid-induced antinociception
12. Physiology of GABA enhancement of benzodiazepines and barbiturates
13. Asystems in the antinarcotic effect of majonoside-R2, a major constituent of vietnamese ginseng, in mice
14. Inhibition of morphine tolerance and dependence by diazepam and its relation to the CNS Met-enkephalin levels
15. Inhibition of morphine-induced tolerance and dependence by a benzodiazepine receptor agonist midazolam in the rat
16. Inhibition of morphine tolerance and dependence by diazepam and its relation to cyclic AMP levels in discrete rat brain regions and spinal cord
17. Inhibition of morphine tolerance and dependence by diazepam and its relation to μ-opioid receptors in the rat brain and spinal cord
18. Ginseng saponins: Influence of neurotransmitter uptake in rat brain synaptosomes
19. Interactions of ginsenosides with ligand-bindings of GABA (A) and GABA (B) receptors
20. Anxiolytic activity of Panax ginseng roots: An experimental study
21. Opioid receptor regulation in mice
22. Kappa opioid analgesia is dependent on serotonergic mechanisms
23. A receptor subtypes
24. A receptors
25. Ginseng: A pharmacological profile
26. Panax ginseng: A pharmacological and clinical appraisal
27. Recent advances in the pharmacology of quaternary salts of bicuculline
28. Serotonergic involvement in the antinociceptive action of and the development of tolerance to the kappa-opioid receptor agonist, U-50, 488H
29. Effects of GABA and glycine receptor antagonists on electrical activity and PAG-induced inhibition of rat dorsal horn neurons
30. Benzodiazepine-induced attenuation of opioid antinociception may be abolished by spinalization or blockade of the benzodiazepine receptor
31. 5)- enkephalin by striatal membranes in the rat
32. Rapid changes in enkephalin levels in rat striatum and hypothalamus induced by diazepam
33. Effect of ginseng on the brain biogenic monoamines and 3′,5′-AMP system. Experiments on rats
34. Diazepam effects on frog skin cyclic nucleotide phosphodiesterase
35. Diazepam inhibits forskolin-stimulated adenyl cyclase activity in human tumour cells