Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host

International Journal of Medical Microbiology

Volumn 292, Issue 7-8, 2003, Pages 537-540

  Kunstmann, Erdmute ^a   Hardt, Cornelia ^b   Crabtree, Jean E ^c   Suerbaum, Sebastian ^d   Epplen, Jörg T ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

CagA; Gene polymorphism; Helicobacter pylori; HLA DRB1; Host factors; TCRBV

Indexed keywords

CAGA PROTEIN; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; T LYMPHOCYTE RECEPTOR;

ALLELE; ARTICLE; BACTERIAL STRAIN; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; GERMANY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HLA SYSTEM; HOMOZYGOTE; HUMAN; IMMUNOGENETICS; MAJOR CLINICAL STUDY; NONHUMAN; OUTCOMES RESEARCH; PEPTIC ULCER;

EID: 0036488843     PISSN: 14384221     EISSN: None     Source Type: Journal    
DOI: 10.1078/1438-4221-00237     Document Type: Article

References (16)

1. Campbell, S., Fraser, A., Holliss, B., Schmid, J., O'Toole, P. W.: Evidence for ethnic tropism of Helicobacter pylori. Infect. Immun. 65, 3708-3712 (1997).
2. Coraddu, F., Sawcer, S., D'Alfonso, S., Lai, M., Hensiek, A., Solla, E., Broadley, S., Mancosu, C., Pugliatti, M., Marrosu, M. G., Compston, A.: A genome screen for multiple sclerosis in Sardinian multiplex families. Eur. J. Hum. Genet. 9, 621-626 (2001).
3. Cover, T. L., Glupczyriski, Y., Lage, A. P., Burette, A., Tummuru, M. K., Perez-Perez, G. I., Blaser, M. J.: Serologic detection of infection with cagA+ Helicobacter pylori strains. J. Clin. Microbiol. 33, 1496-1500 (1995).
4. Crabtree, J. E., Taylor, J. D., Wyatt, J. I., Heatley, R. V., Shallcross, T. M., Tompkins, D. S., Rathbone, B. J.: Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration and gastric pathology. Lancet 338, 332-335 (1991).
5. El-Omar, E. M., Carrington, M., Chow, W. H., McColl, K. E., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C. C., Rothman, N., Lanyon, G., Martin, M., Fraumeni, J. F., Jr., Rabkin, C. S.: Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404, 398-402 (2000). Erratum: Nature 412, 99 (2001).
6. Epplen, C., Jäckel, S., Santos, E. J., D'Souza, M., Poehlau, D., Dotzauer, B., Sindern, E., Haupts, M., Rude, K. P., Weber, F., Stover, J., Poser, S., Gehler, W., Malin, J. P., Przuntek, H., Epplen, J. T.: Genetic predisposition to multiple sclerosis as revealed by immunoprinting. Ann. Neurol. 41, 341-352 (1997).
7. Garcia-Gonzalez, M. A., Lanas, A., Santolaria, S., Crusius, J. B., Serrano, M. T., Pena, A. S.: The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer. Clin. Exp. Immunol. 125, 368-375 (2001).
8. Kunstmann, E., Hardt, C., Elitok, E., Harder, M., Suerbaum, S., Peitz, U., Schmiegel, W., Epplen, J. T.: The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection. Infect. Immun. 68, 6493-6495 (2000).
9. Kunstmann, E., Hardt, C., Treitz, H., Suerbaum, S., Faller, G., Peitz, U., Schmiegel, W., Epplen, J. T.: In the European population HLA-class II genes are not associated with Helicobacter pylori infection. Eur. J. Gastroenterol. Hepatol. 14, 49-53 (2002).
10. Maeda, S., Kanai, F., Ogura, K., Yoshida, H., Ikenoue, T., Takahashi, M., Kawabe, T., Shiratori, Y., Omata, M.: High seropositivity of anti-cagA antibody in Helicobacter pylori-infected patients irrelevant to peptic ulcers and normal mucosa in Japan. Dig. Dis. Sci. 42, 1841-1847 (1997).
11. Shimoyama, T., Fukada, S., Tanaka, M., Mikami, T., Munakata, A., Crabtree, J. E.: CagA seropositivity associated with the development of gastric cancer in a Japanese population. J. Clin. Pathol. 51, 225-228 (1998a).
12. Shimoyama, T., Everett, S. M., Dixon, M. F., Axon, A. T., Crabtree, J. E.: Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J. Clin. Pathol. 51, 765-770 (1998b).
13. Suerbaum, S., Josenhans, C.: Virulence factors of Helicobacter pylori: implications for vaccine development. Mol. Med. Today 5, 32-39 (1999).
14. Van Doorn, L. J., Figueiredo, C., Megraud, F., Pena, S., Midolo, P., Queiroz, D. M., Carneiro, F., Vanderborght, B., Pegado, M. D., Sanna, R., De Boer, W., Schneeberger, P. M., Correa, P., Ng, E. K., Atherton, J., Blaser, M. J., Quint, W. G.: Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 116, 823-830 (1999).
15. Yamaoka, Y., Kodama, T., Kita, M., Kim, J. G., Kashima, K., Graham, D. Y.: Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. J. Clin. Microbiol. 37, 2274-2279 (1999).
16. Yoshitake, S., Okada, M., Kimura, A., Sasazuki, T.: Contribution of major histocompatibility complex genes to susceptibility and resistance in Helicobacter pylori related diseases. Eur. J. Gastroenterol. Hepatol. 11, 875-880 (1999).