Genetic contributions to LDL-C, Apo-B and LDL-C/Apo-B ratio in a sample of Israeli offspring with a parental history of myocardial infarction

Clinical Genetics

Volumn 50, Issue 1, 1996, Pages 1-9

  Friedlander, Y ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Apo B; Coronary heart disease; Family history; LDL C; LDL C Apo B; Linkage; Ratio major gene

Indexed keywords

APOLIPOPROTEIN B; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADOLESCENT; ADULT; ARTICLE; DATA ANALYSIS; FAMILY HISTORY; FEMALE; GENETIC LINKAGE; HEART INFARCTION; HUMAN; HUMAN CELL; ISRAEL; MAJOR CLINICAL STUDY; MAJOR GENE; MALE; MULTIPLE REGRESSION; PRIORITY JOURNAL; PROGENY; RESTRICTION SITE; SIBLING;

EID: 0029793830     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0004.1996.tb02338.x     Document Type: Article

References (61)

1. Amos CI, Elston RC, Srinivasan SR, Wilson AF, Cresanta JL, Ward LJ, Berenson GS. Linkage and segregation analyses of apolipoproteins A1 and B, and lipoprotein cholesterol levels in a large pedigree with excess coronary heart disease: The Bogalusa Heart Study. Genet Epidemiol 1987: 4: 115-128.
2. Austin MA, Breslow JL, Hennekens CH, Buring JE, Willett WS, Krauss RM. Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA 1988a: 260: 1917-1921.
3. Austin MA, King M-C, Vranzian KM, Newman B, Krauss RM. Inheritance of low-density lipoprotein subclass patterns: results of complex segregation analysis. Am J Hum Genet 1988b: 43: 838-846.
4. Austin MA, Brunzell JD, Fitch WL, Krauss RM. Inheritance of low-density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis 1990: 10: 520-530.
5. Austin MA, Wijsman E, Guo S, Krauss RM, Brunzell JD, Deeb S. Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia. Genet Epidemiol 1991: 8: 287-297.
6. Austin MA, Newman B. Selby JV, Edwards K, Mayer EJ, Krauss RM. Genetics of low-density lipoprotein subclasses in women twins: concordance, heritability and commingling analysis. Arterioscler Thromb 1993: 13: 687-695.
7. Beaty TH, Kwiterovitch PO, Khoury MJ, White S, Bachorik PS, Smith HH, Sniderman A. Genetic analysis of plasma sitosterol, apoprotein B and lipoproteins in a large Amish pedigree with sitosterolemia. Am J Hum Genet 1986: 38: 492-504.
8. Berg K. DNA polymorphism at the apolipoprotein B locus is associated with lipoprotein level. Clin Genet 1986: 30: 515-520.
9. Blackwelder WC, Elston RC. Power and robustness of sib-pair linkage test and extension to larger sibships. Commun Stat Theor Meth 1982: 11: 449-484.
10. Box GEP, Cox DR. An analysis of transformations. J Royal Stat Soc 1964: 26: Series B: 211-252.
11. Campos H. Genest JJ, McNamara JR, Ordovas JM, Wilson PWF, Schaefer EJ. Low-density lipoprotein particle size and coronary artery disease. Circulation 1990: 82 (suppl III): 349.
12. Campos H. Genest JJ, Blijlevens E, McNamara JR, Jenner JL, Ordovas JM, Wilson PWF, Schaefer EJ. Low density lipoprotein particle size and coronary artery disease. Arterioscler Thromb 1992a: 12: 187-195.
13. Campos H, Blijlevens E, McNamara JR, Ordovas JM, Posner BM, Wilson PWF, Castelli WP, Schaefer EJ. LDL particle size distribution: results from the Framingham Offspring Study. Arterioscler Thromb 1992b: 12: 1410-1419.
14. Coresh J. Kwiterovich PO, Bachorik P. Association of low density lipoprotein size, density and composition with premature coronary heart disease. Circulation (Suppl I) 1992a: 86: 1811.
15. Coresh J, Beaty TH, Kwiterovich PO, Antonarakis SE. Pedigree and sib-pair linkage analysis suggest the apolipoprotein B is not the major gene influencing plasma apolipoprotein B levels. Am J Hum Genet 1992b: 50: 1038-1045.
16. Cox DR, Hinkley DV. Theoretical statistics. London: Chapman and Hall, 1974.
17. Crouse JR, Parks JS, Schey HM. Studies of low density lipoprotein molecular weight in human beings with coronary artery disease. J Lipid Res 1985: 26: 566-574.
18. de Graaf J, Swinkels DW, de Haan AFJ, Demacker PNM, Stalenhoef FH. Both inherited susceptibility and environmental exposure determine the low-density lipoprotein-subfraction pattern distribution in healthy Dutch families. Am J Hum Genet 1992: 51: 1295-1310.
19. Dixon WJ, Massey FJ Jr. Introduction to statistical analysis, 3rd edn. New York: McGraw-Hill, 1969.
20. Fain PR. Characteristics of simple sibship variance test for the detection of major loci and applications for height, weight, and spatial performance. Ann Hum Genet 1978: 42: 109-129.
21. Freedman DS, Srinivasan SR, Shear CL, Franklin FA, Webber LS, Berenson GS. The relationship of apolipoproteins A1 and B in children to parental myocardial infarction. N Engl J Med 1986: 315: 721-726.
22. Friedlander Y, Kark JD, Eisenberg S, Stein Y. Calculation of LDL-cholesterol from total cholesterol, triglyceride and HDL-cholesterol: a comparison of methods in the Jerusalem Lipid Research Clinic prevalence study. Isr J Med Sci 1982: 18: 1242-1252.
23. Friedlander Y, Kark JD, Stein Y. Family history as an independent risk factor for coronary heart disease. Br Heart J 1985: 53: 382-387.
24. Friedlander Y, Kark JD, Stein Y. Biological and environmental sources of variation in plasma lipids and lipoproteins: the Jerusalem Lipid Research Clinic. J Hum Hered 1986: 36: 143-153.
25. Friedlander Y, Kaufmann NA, Cedar H, Kark JD. Xbal polymorphism of the apolipoprotein B gene and plasma lipid and lipoprotein response to dietary fat and cholesterol: a clinical trial. Clin Genet 1993a: 43: 223-231.
26. Friedlander Y, Dann EJ, Leitersdorf E. Absence of familial defective apolipoprotein B-100 in Israeli patients with dominantly inherited hypercholesterolemia and in offspring with parental history of myocardial infarction. Hum Genet 1993b: 91: 299-300.
27. Friedlander Y, Kaufmann NA, Cedar H, Weinberg N, Kark JD. The role of Xbal polymorphism of the apolipoprotein B gene in determining levels and covariability of lipid and lipoprotein variables in a sample of Israeli offspring with family history of myocardial infarction. Atherosclerosis 1993c: 98: 165-177.
28. Friedlander Y, Berry EM, Eisenberg S, Stein Y, Leitersdorf E. Plasma lipids and lipoproteins response to a dietary challenge: analysis of four candidate genes. Clin Genet 1995: 47: 1-12.
29. Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge. Clin Chem 1972: 18: 499-502.
30. Goldstein JL, Brown MS. Familial hypercholesterolemia. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS, eds. The metabolic basis of inherited disease, 5th edn. New York: McGraw-Hill, 1983: 672-712.
31. Green P, Owen ARG, Namboodiri K, Hewitt D, Williams LR, Elston RC. The Collaborative Lipid Research Clinics Program Family Study: detection of major genes influencing lipids levels by examination of heterogeneity of familial variances. Genet Epidemiol 1984: 1: 123-141.
32. Haseman JK, Elston RC. The investigation of linkage between a quantitative trait and marker locus. Behav Genet 1972: 2: 3-19.
33. Hasstedt SJ, Wu L, Williams RR. Major locus inheritance of apolipoprotein B in Utah pedigrees. Genet Epidemiol 1987: 4: 67-76.
34. Hegele RA, Huang L-S, Herbert PN, Blum CB, Buring JE, Hennekens CH, Breslow JL. Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction. N Engl J Med 1986: 315: 1509-1515.
35. Hewitt D, Jones GJL, Godin GJ, Wraight D, Breckenridge WC, Little JA, Steiner G, Mishkel MA. Nature of the familial influence on plasma lipid levels. Atheroscler 1979: 32: 381-396.
36. Hodge SE. The information contained in multiple sibling pairs. Genet Epidemiol 1984: 1: 109-122.
37. Islam S, Gutin B, Manos T, Smith C, Treiber F. Low-density lipoprotein cholesterol/apolipoprotein B-100 ratio: interaction of family history of premature atherosclerotic coronary artery disease with race and gender in 7 to 11 year olds. Pediatrics 1994: 94: 494-499.
38. Kwon JM, Boehnke M, Burns TL, Moll PP. Commingling and segregation analyses: comparison of results from a simulation study of a quantitative trait. Genet Epidemiol 1990: 7: 57-68.
39. LaBelle M, Austin MA, Rubin E, Krauss RM. Linkage analysis of low-density lipoprotein subclass phenotypes and the apolipoprotein B gene. Genet Epidemiol 1991: 8: 269-275.
40. Law K, Wallis SC, Powell LM, Pease RJ, Brunt H, Priestley LM, Knott TJ, Scott J, Allman DG, Miller GJ, Rajput J, Miller NE. Common DNA polymorphism within coding sequence of apolipoprotein B gene associated with altered lipid levels, Lancet 1986: i: 1301-1303.
41. Liang AK, Amos CI, DeMeester C, Diep A, Xia YR, Elston RC, Srinivasan SR, Berenson GS, Lusis AJ. Linkage between the APOB gene and serum ApoB levels in a large pedigree from the Bogalusa Heart Study. Genet Epidemiol 1994: 11: 29-40.
42. MacLean CJ, Morton NE, Elston RC, Lew R. Analysis of familial resemblance IV. Operational characteristics of segregation analysis. Am J Hum Genet 1975: 27: 365-384.
43. MacLean CJ, Morton NE, Elston RC, Yee S. Skewness in commingled distributions. Biometrics 1976: 32: 695-699.
44. Merat P. Distribution de frequencies, interpretation du determinisme genetique des characters quantitatifs et recherche de "genes majeurs". Biometrics 1968: 24: 277-293.
45. Motti C, Funke H, Rust S, Dergunov A, Assmann G. Using mutagenic polymerase chain reaction primers to detect carriers of familial defective apolipoprotein B-100. Clin Chem 1991: 37: 1762-1766.
46. Myant NB, Gallagher J, Babir M, Thompson GR, Wile D, Humphries SE. Restriction fragment length polymorphisms in the apo B gene in relation to coronary heart disease. Atherosclerosis 1989: 77: 193-201.
47. Namboodiri KK, Kaplan EB, Heuch I, Elston RC, Green PP, Rao DC, Laskarzewski P, Glueck CJ, Rifkind BM. The Collaborative Lipid Research Clinics Family Study: biological and cultural determinants of familial resemblance for plasma lipids and lipoproteins. Genet Epidemiol 1985: 2: 227-254.
48. Nishina PM, Johnson JP, Naggert JK, Krauss RM. Linkage of atherogenic lipoprotein phenotype to the low density lipoprotein receptor locus on the short arm of chromosome 19. Proc Natl Acad Sci USA 1992: 89: 708-712.
49. Ott J. Detection of rare major genes in lipid levels. Hum Genet 1979: 51: 79-91.
50. Pairitz G, Davingnon J, Mailloux H, Sing CF. Sources of interindividual variation in the quantitative levels of apolipoprotein B in pedigrees ascertained through lipid clinic. Am J Hum Genet 1988: 43: 311-321.
51. Rigby PWJ, Dieckmann M, Rhodes C, Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol 1977: 113: 237.
52. SAGE. Statistical Analysis for Genetic Epidemiology, Version 2.2. Computer program package available from the Department of Biometry and Genetics. New Orleans: LSU Medical Center, 1992.
53. Schonfeld G, Lees RS, George PK, Pfleger B. Assay of total plasma apoprotein B concentration in human subjects. J Clin Invest 1974: 53: 1458-1467.
54. Slack J, Evans KA. The increased risk of death from ischaemic heart disease in first degree relatives of 121 men and 96 women with ischaemic heart disease. J Med Genet 1966: 3: 239-257.
55. Sniderman A, Shapiro S, Marpole D, Skinner B, Kwiterovich PO Jr. Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human low density (β) lipoprotein]. Proc Natl Acad Sci USA 1980: 77: 604-608.
56. Sniderman A, Teng B, Genest J, Cianflone K, Wacholder S, Kwiterovich PO Jr. Familial aggregation and early expression of hyperapobetalipoproteinemia. Am J Cardiol 1985: 55: 291-295.
57. Southern EM. Detection of specific sequence among DNA fragments separated by gel electrophoresis. J Mol Biol 1975: 93: 503-517.
58. Swinkels DW, Demacker PNM, Hendricks JCM, van't Laar A. Low-density lipoprotein subfractions and relationship of other risk factors for coronary artery disease in healthy individuals. Arterioscler Thromb 1989: 9: 604-613.
59. Teng B, Thompson GR, Sniderman AD, Forte TM, Krauss RM, Kwiterovich PO, Jr. Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia. Proc Natl Acad Sci USA 1983: 80: 6662-6666.
60. Tikkanen MJ, Xu C-F, Hamalainen T, Talmud P, Sarna S, Huttunen JK, Pietinen P, Humphries SE. Xbal polymorphism of the apolipoprotein B gene influences plasma lipid response to diet intervention. Clin Genet 1990: 37: 327-334.
61. WHO. MONICA manual, World Health Organization, Geneva, 1986.