T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region

Genes and Immunity

Volumn 3, Issue 1, 2002, Pages 38-42

  Wang, Z C ^a,b   Yunis, E J ^b   De los Santos, M J ^a   Xiao, L ^a   Anderson, D J ^a   Hill, J A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

IL1B; Polymorphism; Recurrent pregnancy loss; Th1 immunity

Indexed keywords

CELL ANTIGEN; CELL EXTRACT; GAMMA INTERFERON; INTERLEUKIN 1BETA; ANTIGEN; INTERLEUKIN 1;

ARTICLE; CELL LINE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; HIGH RISK PREGNANCY; HOMOZYGOSITY; HUMAN; IMMUNITY; INTERFERON PRODUCTION; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MEDICAL RECORD; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; RECURRENT DISEASE; SPONTANEOUS ABORTION; TH1 CELL; TROPHOBLAST; ANAMNESIS; BIOSYNTHESIS; CASE CONTROL STUDY; CELL CULTURE; COMPARATIVE STUDY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HOMOZYGOTE; IMMUNOLOGY; PREGNANCY; RECURRENT ABORTION; RETROSPECTIVE STUDY;

ABORTION, HABITUAL; ANTIGENS; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; GENE FREQUENCY; GENOTYPE; HOMOZYGOTE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; POLYMORPHISM, GENETIC; PREGNANCY; PROMOTER REGIONS (GENETICS); REPRODUCTIVE HISTORY; RETROSPECTIVE STUDIES; TH1 CELLS; TROPHOBLASTS; VARIATION (GENETICS);

EID: 0036480136     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363812     Document Type: Article

References (35)

1. Regan L. Recurrent miscarriage. BMJ 1991; 302: 543-544.
2. Hill JA. in Creasy R, Resnik R (eds). Maternal-Fetal Medicine. 4th Edition. WB Saunders Co, 1998; pp 423-443.
3. H2 phenomenon?. Immunol Today 1993; 14: 353-356.
4. Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997; 18: 478-482.
5. Hill JA, Anderson DJ, Polgar K. T helper 1-type cellular immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 1995; 273: 1933-1936.
6. Raghupathy R, Makhseed M, Azizieh F et al. Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol 1999; 196: 122-130.
7. Piccinni M-P, Piccinni MP, Beloni L et al. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 1998; 4: 1020-1024.
8. Hill JA, Polgar K, Harlow BL, Anderson DJ. Evidence of embryo and trophoblast-toxic cellular immune response(s) in women with recurrent spontaneous abortion. Am J Obstet Gynecol 1992; 166: 1044-1052.
9. Yui J, Garcia-Lloret M, Wegmann TG, Guilbert L. Cytotoxicity of tumor necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts. Placenta 1994; 15: 819-827.
10. Khan-Hanjani A, Lacaille D, Holar D et al. Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to and severity of, rheumatoid arthritis. Lancet 2000; 356: 820-825.
11. McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature 1994; 371: 508-510.
12. Nemetz A, Nosti-Escanilla MP, Molnar T et al. IL1B gene polymorphisms influence the course and severity of inflammatory bowel disease. Immunogenetics 1999; 49: 527-531.
13. Wilkinson RJ, Patel P, Llewelyn M et al. Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1β on tuberculosis. J Exp Med 1999; 189: 1863-1873.
14. El-Omar EM, Carrington M, Chow W-H et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398-402.
15. Robertson SA, Seamark RF, Guilbert LJ, Wegmann TG. The role of cytokines in gestation. Crit Rev Immunol 1994; 14: 239-292.
16. Lichtman AH, Chin J, Schmidt JA, Abbas AK. Role of interleukin 1 in the activation of T lymphocytes. Proc Natl Acad Sci USA 1988; 85: 9699-9703.
17. Manetti R, Barak V, Piccinni MP et al. Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones. Res Immunol 1994; 145: 93-100.
18. Oriss TB, McCArthy SA, Morel BF, Campana MA, Morel PA. Crossregulation between T helper cell (Th)1 and Th2: inhibition of Th2 proliferation by IFN-gamma involves interference with IL-1. J Immunol 1997; 158: 3666-3672.
19. Huber M, Rutherford A, Meister W et al. TCR and IL-1 mediated co-stimulation reveals an IL-4-independent way of Th2 cell proliferation. Int Immunol 1996; 8: 1257-1263.
20. Hunter CA, Chizzonite, Remington JS. IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. J Immunol 1995; 155: 4347-4354.
21. Tominaga K, Yoshimoto T, Torigoe K et al. IL-12 synergizes with IL-18 or IL-1 beta for IFN-gamma production from human T cells. Int Immunol 2000; 12: 151-160.
22. Simon C, Valbuena D, Krussel J et al. Interleukin-1 receptor antagonist prevents embryonic implantation by a direct effect on the endometrial epithelium. Fertil Steril 1998; 70: 896-906.
23. Librach CL, Feigenbaum SL, Bass KE. Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro. J Biol Chem 1994; 269: 493-500.
24. Von Wolff M, Thaler CJ, Strowitzki T et al. Regulated expression of cytokines in human endometrium throughout the menstrual cycle: dysregulation in habitual abortion. Mol Hum Reprod 2000; 6: 627-634.
25. di Giovine FS, Takhsh E, Blakemore AIF, Duff GW. Single base polymorphism at -511 in the human interleukin-1β gene. Hum Mol Genet 1993; 1: 450.
26. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup JA. TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur J Clin Invest 1992; 22: 396-402.
27. Unfried G, Tempter C, Schneeberger C et al. Interleukin 1 receptor antagonist polymorphism in women with idiopathic recurrent miscarriage. Fertil Steril 2001; 75: 683-687.
28. Yamada H, Polgar K, Hill JA. Cell-mediated immunity to trophoblast antigens in women with recurrent spontaneous abortion. Am J Obstet Gynecol 1994; 170: 1339-1344.
29. Berkowitz RS, Alberti OJ, Hunter NJ, Goldstein DP, Anderson DJ. Localization of stage-specific embryonic antigens in hydatiform mole, normal placenta and gestational choriocarcinoma. Gynecol Oncol 1985; 1: 70-77.
30. Berkowitz RS, Umpiere SA, Goldstein DP, Anderson DJ. Cross-reactivity of monoclonal antibodies against lymphocyte markers with trophoblast cells of normal placenta, hydatiform mole and gestational choriocarcinima. Gynecol Oncol 1988; 29: 94-100.
31. Faas M, Bouman A, Moesa H, Heineman MJ, de Lei j L, Schuiling G. The immune response during the luteal phase of the ovarian cycle: a Th2-type response. Fertil Steril 2000; 74: 1008-1013.
32. Canon JG, Dinarello CA. Increased plasma interleukin-1 activity in women after ovulation. Science 1985; 227: 1247-1249.
33. Al-Harthi L, Wright DJ, Anderson D et al. The impact of the ovulatory cycle on cytokine production: evaluation of systemic, cervicovaginal, and salivary compartments. J Interferon Cytokine Res 2000; 20: 719-724.
34. Santtila S, Savinainen K, Hurme M. Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1 beta production in vitro. Scand. J Immunol 1998; 47: 195-198.
35. Guasch JF, Bertina RM, Reitsma PH. Five novel intragenic dimorphisms in the human interleukin-1 genes combine to high informativity. Cytokine 1996; 8: 598-602.