Anti-CD38 autoantibodies: Characterisation in new-onset Type I diabetes and latent autoimmune diabetes of the adult “LADA” and comparison with other islet autoantibodies

Diabetologia

Volumn 45, Issue 12, 2002, Pages 1667-1677

  Mallone, Roberto ^a   Ortolan, E ^b   Pinach, S ^a   Volante, M ^b   Zanone, M M ^a   Bruno, G ^a   Baj, G ^c   Lohmann, T ^d   Cavallo Perin, P ^a   Malavasi, F ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

ADP ribosyl cyclase; Autoimmunity; Beta cell; Calcium; Ectoenzymes; GAD; ICA; Islet cell antibodies

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; AUTOANTIBODY; C PEPTIDE; CALCIUM; CD38 ANTIGEN; CD38 PROTEIN, HUMAN; GLUTAMATE DECARBOXYLASE; ICA512 AUTOANTIBODY; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PANCREAS ISLET CELL ANTIBODY; CD38 AUTOANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; AGED; ARTICLE; BLOOD; CASE CONTROL STUDY; CHILD; COHORT ANALYSIS; FEMALE; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; ADULT; CONTROLLED STUDY; ENZYME CHEMISTRY; IMMUNOASSAY; IMMUNOFLUORESCENCE; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHOTOREACTIVITY; PREVALENCE; PRIORITY JOURNAL;

ADOLESCENT; ADP-RIBOSYL CYCLASE; AGED; ANTIGENS, CD; ANTIGENS, CD38; AUTOANTIBODIES; C-PEPTIDE; CALCIUM; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED;

EID: 0036460036     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0940-4     Document Type: Article

References (47)

1. Atkinson MA, Eisenbarth GS “2001” Type 1 diabetes: New perspectives on disease pathogenesis and treatment. Lancet 358:221-229
2. Yki-Jarvinen H “1992” Glucose toxicity. Endocr Rev 13:415-431
3. Unger RH, Zhou YT “2001” Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 50:S118-S121
4. Grill V, Bjorklund A “2001” Overstimulation and beta-cell function. Diabetes 50:S122-S124
5. Pratley RE, Weyer C “2001” The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus. Diabetologia 44:929-945
6. Wilkin TJ “2001” The accelerator hypothesis: Weight gain as the missing link between Type I and Type II diabetes. Diabetologia 44:914-922
7. Bottazzo GF, Florin-Christensen A, Doniach D “1974” Islet cell antibodies in diabetes mellitus with autoimmune poly-endocrine deficiencies. Lancet ii:1279-1283
8. Myers MA, Rabin DU, Rowley MJ “1995” Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes 44:1290-1295
9. Atkinson MA, Kaufman DL, Newman D, Tobin AJ, Maclaren NK “1993” Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J Clin Invest 91:350-356
10. Verge CF, Stenger D, Bonifacio E et al. “1998” Combined use of autoantibodies “IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies” in type 1 diabetes. Combinatorial Islet Autoantibody Workshop. Diabetes 47:1857-1866
11. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E “1995” Identification of protein tyrosine phosphatase-like IA2 “islet cell antigen 512” as the insulin-dependent diabetes-related 37/40 K autoantigen and a target of islet-cell antibodies. J Immunol 155:5419-5426
12. Seissler J, Sonnaville JJ de, Morgenthaler NG et al. “1998” Immunological heterogeneity in Type I diabetes: Presence of distinct autoantibody patterns in patients with acute onset and slowly progressive disease. Diabetologia 41:891-897
13. Lohmann T, Seissler J, Verlohren H-J et al. “1997” Distinct genetic and immunological features in patients with onset of IDDM before and after age 40. Diabetes Care 20:524-529
14. Seissler J, Hering B, Richter W et al. “1992” Antibodies to the Mr 64,000 “64 K” protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired beta-cell function. Diabetologia 35:550-554
15. Christie MR, Tun RY, Lo SS et al. “1992” Antibodies to glutamic acid decarboxylase and tryptic fragments of islet 64kD antigen as distinct markers for the development of insulin-dependent diabetes: Studies with identical twins. Diabetes 41:782-787
16. Christie MR, Genovese S, Cassidy D et al. “1994” Antibodies to islet 37 k antigen, but not glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes 43:1254-1259
17. Verge CF, Gianani R, Kawasaki E et al. “1996” Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45:926-933
18. Groop LC, Bottazzo GF, Doniach D “1986” Islet cell antibodies identify latent type I diabetes in patients aged 35-75 years at diagnosis. Diabetes 35:237-241
19. Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles W, Mackay IR “1993” Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42:359-362
20. Tuomi T, Carlsson A, Li H et al. “1999” Clinical and genetic characteristics of type II diabetes with and without GAD antibodies. Diabetes 48:150-157
21. Lohmann T, Kellner K, Verlohren H-J et al. “2001” Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults “LADA”. Diabetologia 44:1005-1010
22. Pozzilli P, Di Mario U “2001” Autoimmune diabetes not requiring insulin at diagnosis “Latent Autoimmune Diabetes of the Adult”. Diabetes Care 24:1460-1467
23. Ikehata F, Satoh J, Nata K et al. “1998” Autoantibodies against CD38 “ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase” that impair glucose-induced insulin secretion in noninsulin-dependent diabetes patients. J Clin Invest 102:395-401
24. Pupilli C, Giannini S, Marchetti P et al. “1999” Autoantibodies to CD38 “ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase” in Caucasian patients with diabetes: Effects on insulin release from human islets. Diabetes 48:2309-2315
25. Mallone R, Ortolan E, Baj G et al. “2001” Autoantibody response to CD38 in Caucasian patients with type 1 and type 2 diabetes: Immunological and genetic characterization. Diabetes 50:752-762
26. Ferrero E, Malavasi F “1999” The metamorphosis of a molecule: From soluble enzyme to the leukocyte receptor CD38. J Leukoc Biol 65:151-161
27. Mehta K, Malavasi F “2000” Human CD38 and Related Molecules. Karger, Basel
28. Takasawa S, Nata K, Yonekura H, Okamoto H “1993” Cyclic ADP-ribose in insulin secretion from pancreatic beta cells. Science 259:370-373
29. Okamoto H, Takasawa S, Nata K “1997” The CD38-cyclic ADP-ribose signalling system in insulin secretion: Molecular basis and clinical implications. Diabetologia 40:1485-1491
30. Antonelli A, Baj G, Marchetti P et al. “2001” Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets. Diabetes 50:985-991
31. Bruno G, Merletti F, Biggeri A et al. “2001” Increasing trend of Type I diabetes in children and young adults in the province of Turin “Italy”. Analysis of age, period and birth cohort effects from 1984 to 1996. Diabetologia 44:22-25
32. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus “2002” Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 25:S5-S20
33. Alberti KGM, Zimmet PZ for the WHO Consultation “1998” Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 15:539-553
34. Munshi CB, Fryxell KB, Lee HC, Branton WD “1997” Large-scale production of human CD38 in yeast by fermentation. Methods Enzymol 280:318-330
35. 35S]GAD 65-ligand binding assay. Clin Chem 43:779-785
36. Rabin DU, Pleasic SM, Shapiro JA et al. “1994” Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152:3183-3188
37. Hagopian WA, Sanjeevi CB, Kockum I et al. “1995” Glutamate decarboxylase-, insulin-, and islet cell- antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95:1505-1511
38. Bonifacio E, Genovese S, Braghi S et al. “1995” Islet autoantibody markers in IDDM: Risk assessment strategies yielding high sensitivity. Diabetologia 38:816-822
39. Dotta F, Falorni A, Tiberti C et al. “1997” Autoantibodies to the GM2-1 islet ganglioside and to GAD-65 at type 1 diabetes onset. J Autoimmun 10:585-588
40. Yokota I, Matsuda J, Naito E, Michinori I, Shima K, Kuroda Y “1998” Comparison of GAD and ICA512/IA-2 antibodies at and after the onset of IDDM. Diabetes Care 21:49-52
41. Takasawa S, Tohgo A, Noguchi N et al. “1993” Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. J Biol Chem 268:26052-26054
42. Van de Winkle M, Maes E, Pipeleers D “1982” Islet cell analysis and purification by light scatter and autofluorescence. Biochem Biophys Res Commun 107:525-532
43. Jindal RM, McShane P, Gray DW, Morris PJ “1994” Isolation and purification of pancreatic islets by fluorescence activated islet sorter. Transplant Proc 26:653
44. Vives M, Somoza N, Soldevila G et al. “1992” Reevaluation of autoantibodies to islet cell membrane in IDDM. Failure to detect islet cell surface antibodies using human islet cells as substrate. Diabetes 41:1624-1631
45. Moulias R, Proust J, Wang A et al. “1984” Age-related increase in autoantibodies. Lancet i:1128-1129
46. Bach JF, Koutouzov S, van Endert PM “1998” Are there unique autoantigens triggering autoimmune diseases? Immunol Rev 164:139-155
47. Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren P-O, Orrenius S “2001” Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes 50:S44-S47