Do recurrent seizures cause neuronal damage? A series of studies with MRI volumetry in adults with partial epilepsy

Progress in Brain Research

Volumn 135, Issue , 2002, Pages 279-295

  Kälviäinen, Reetta ^a   Salmenperä, Tuuli ^a  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; AMYGDALOID NUCLEUS; BRAIN SIZE; CHRONIC DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EPILEPSY; EPILEPTIC STATE; FEMALE; FOCAL EPILEPSY; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; NEURORADIOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RECURRENT DISEASE; SEIZURE; TEMPORAL LOBE EPILEPSY;

EID: 0036458539     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(02)35026-X     Document Type: Conference Paper

References (70)

1. Barr, W.B., Ashtari, M. and Schaul, N. (1997) Bilateral reductions in hippocampal volume in adults with epilepsy and a history of febrile seizures. J. Neurol. Neurosurg. Psychiatry, 63: 461-467.
2. Bernasconi, N., Bernasconi, A., Andermann, F., Dubeau, F., Feindel, W. and Reutens, D.C. (1999) Entorhinal cortex in temporal lobe epilepsy. A quantitative MRI study. Neurology, 52: 1870-1876.
3. Bigler, E.D., Blatter, D.D., Anderson, C.V., Johnson, S.C., Gale, S.D., Hopkins, R.O. and Burnett, B. (1997) Hippocampal volume in normal aging and traumatic head injury. Am. J. Neuroradiol., 18: 11-23.
4. Briellmann, R.S., Berkovic, S.F. and Jackson, G.D. (2000) Men may be more vulnerable to seizure associated brain damage. Neurology, 55: 1479-1485.
5. Bronen, R.A., Cheung, G., Charles, J.T., Kim, J.H., Spencer, D.D., Spencer, S.S., Sze, G. and McCarthy, G. (1991) Imaging findings in hippocampal sclerosis: Correlation with pathology. Am. J. Neuroradiol., 12: 933-940.
6. Bruton, C.J. (1988) The Neuropathology of Temporal Lobe Epilepsy. Institute of Psychiatry, Maudsley monographs, 31, Oxford University Press, New York.
7. Cavanagh, J.B. and Meyer, A. (1956) Aetiological aspects of Ammon's horn sclerosis associated with temporal lobe epilepsy. Br. Med. J., 2: 1403-1407.
8. Cavazos, J.E., Das, I. and Sutula, T.P. (1994) Neuronal loss induced in limbic pathways by kindling: Evidence for induction of hippocampal sclerosis by repeated brief seizures. J. Neurosci., 14: 3106-3121.
9. Cendes, F., Andermann, F., Dubeau, F., Gloor, P., Evans, A., Jones-Gotman, M., Olivier, A., Andermann, E., Robitaille, Y., Lopes-Cendes, I., Peters, T. and Melanson, D. (1993a) Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: An MRI volumetric study. Neurology, 43: 1083-1087.
10. Cendes, F., Andermann, F., Gloor, P., Evans, A., Jones-Gotman, M., Watson, C., Melanson, D., Olivier, A., Peters, T., Lopes-Cendes, I. and Leroux, G. (1993b) MRI volumetric measurements of amygdala and hippocampus in temporal lobe epilepsy. Neurology, 43: 719-725.
11. Cendes, F., Andermann, F., Gloor, P., Lopes-Cendes, I., Andermann, E., Melanson, D., Jones-Gotman, M., Robitaille, Y., Evans, A. and Peters, T. (1993c) Atrophy of mesial structures in patients with temporal lobe epilepsy: Cause or consequence of repeated seizures. Ann. Neurol., 34: 795-801.
12. Cendes, F., Leproux, F., Melanson, D., Ethier, R., Evans, A., Peters, T. and Andermann, F. (1993d) MRI of amygdala and hippocampus in temporal lobe epilepsy. J. Comput. Assisted Tomogr., 17: 206-210.
13. Cendes, F., Andermann, F., Gloor, P., Gambardella, A., Lopes- Cendes, I., Watson, C., Evans, A., Carpenter, S. and Olivier, A. (1994) Relationship between atrophy of the amygdala and ictal fear in temporal lobe epilepsy. Brain, 117: 739-746.
14. Du, F., Eid, T., Lothman, E.W., Köhler, C. and Schwarcz, R. (1995) Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J. Neurosci., 10: 6301-6313.
15. Duncan, J.S. (1997) Imaging and epilepsy. Invited Review. Brain, 120: 339-377.
16. Duncan, J.S. and Sagar, H.J. (1987) Seizure characteristics, pathology and outcome after temporal lobectomy. Neurology, 37: 405-409.
17. Engel Jr., J. (1996) Introduction to temporal lobe epilepsy. Epilepsy Res., 26: 141-150.
18. Falconer, M.A. and Cavanagh, J.B. (1959) Clinico-pathological considerations of temporal lobe epilepsy due to small focal lesions. Brain, 82: 483-503.
19. Falconer, M.A., Serafetinides, E.A. and Corsellis, J.A.N. (1964) Etiology and pathogenesis of temporal lobe epilepsy. Arch. Neurol., 10: 233-248.
20. Fernandez, G., Effenberger, O., Vinz, B., Steinlein, O., Elger, C.E., Dohring, W. and Heinze, H.J. (1998) Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis. Neurology, 50: 909-917.
21. Free, S.L., Li, L.M., Fish, D.R., Shorvon, S.D. and Stevens, J.M. (1996) Bilateral hippocampal volume loss in patients with a history of encephalitis or meningitis. Epilepsia, 37: 400-405.
22. Gowers, W.R. (1881) Epilepsy and Other Chronic Convulsive Disorders; Their Cases, Symptoms and Treatment. William Wood, New York, 225.
23. Grunewald, R.A., Jackson, G.D., Connelly, A. and Duncan, J.S. (1994) MR detection of hippocampat disease in epilepsy: Factors influencing T2 relaxation time. Am. J. Neuroradiol., 15: 1149-1156.
24. Harvey, A.S., Grattan-Smith, J.D., Desmond, P.M., Chow, C.W. and Berkovic, S.F. (1995) Febrile seizures and hippocampal sclerosis: Frequent and related findings in intractable temporal lobe epilepsy of childhood. Pediatr. Neuro., 12: 201-206.
25. Harvey, A.S., Berkovic, S.F., Wrennall, J.A. and Hopkins, I.J. (1997) Temporal lobe epilepsy in childhood: clinical, EEG, and neuroimaging findings and syndrome classification in a cohort with new-onset seizures. Neurology, 49: 960-968.
26. Hauser, W.A. and Hesdorffer, D.C. (2001) Epidemiology of intractable epilepsy. In: H.O. Luders and Y.G. Comair (Eds.), Epilepsy Surgery. Lippincott, Williams and Wilkins, Philadelphia, PA, pp. 55-61.
27. Hudson, L.P., Munoz, D.G., Miller, L., McLachlan, R.S., Girvin, J.P. and Blume, W.T. (1993) Amygdaloid sclerosis in temporal lobe epilepsy. Ann. Neurol., 33: 622-631.
28. Insausti, R., Juottonen, K., Soininen, H., Insausti, A.M., Partanen, K., Vainio, P., Laakso, M.P. and Pitkänen, A. (1998) MRI-based volumetric analyses of the human entorhinal, perirhinal and temporopolar cortices. Am. J. Neuroradiol., 19: 659-671.
29. Jack Jr., C.R., Sharbrough, F.W., Twomey, C.K., Cascino, G.D., Hirschorn, K.A., Marsh, W.R., Zinsmeister, A.R. and Scheithauer, B. (1990) Temporal lobe seizures: Lateralization with MR volume measurements of the hippocampal formation. Radiology, 175: 423-429.
30. Jackson, G.D., Kuzniecky, R.I. and Cascino, G.D. (1994) Hippocampal sclerosis without detectable hippocampal atrophy. Neurology, 44: 42-46.
31. Jokeit, H., Ebner, A., Arnold, S., Schuller, M., Antke, C., Huang, Y., Steinmetz, H., Seitz, R.J. and Witte, O.W. (1999) Bilateral reductions of hippocampal volume, glucose metabolism, and WADA hemispheric memory performance are related to the duration of mesial temporal lobe epilepsy. J. Neurol., 246: 926-933.
32. Kapur, N., Barker, S., Burrows, E.H., Ellison, D., Brice, J., Illis, L.S., Scholey, K., Colbourn, C., Wilson, B. and Loates, M. (1994) Herpes simplex encephalitis: long term magnetic resonance imaging and neuropsychological profile.,J. Neurol. Neurosurg. Psychiatry, 57: 1334-1342.
33. Kuks, J.B., Cook, M.J., Fish, D.R., Stevens, J.M. and Shorvon, S.D. (1993) Hippocampal sclerosis in epilepsy and childhood febrile seizures. Lancet, 342: 1391-1394.
34. Kuzniecky, R.I., Burgard, S., Bilir, E., Morawetz, R., Gilliam, F., Faught, E., Black, L. and Palmer, C. (1996) Qualitative MRI segmentation in mesial temporal sclerosis: Clinical correlations. Epilepsia, 37: 433-439.
35. Kälviäinen, R., Äikiä, M., Partanen, K., Salmenperä, T., Vainio, P. and Pitkänen, A. (1997a) Hippocampal damage correlates with poor memory performance but not with early prognosis of newly diagnosed patients with epilepsy. Epilepsia, 38(Suppl. 8): S144-S145.
36. Kälviäinen, R., Salmenperii, T., Partanen, K., Vainio, P., Riekkinen Sr., P. and Pitkänen, A. (1997b) MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy. Epilepsy Res., 28: 39-50.
37. Kälviäinen, R., Salmenperä, T., Partanen, K., Vainio, P., Riekkinen Sr., P. and Pitkänen, A. (1998) Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy. Neurology, 50: 1377-1382.
38. Kälviäinen, R., Salmenperä, T., Partanen, K., Vainio, P., Riekkinen Sr., P. and Pitkänen, A. (1999) Hippocampal damage and the onset of epilepsy. Neurology, 52: 1717.
39. Lehericy, S., Semah, F., Hasboun, D., Dormont, D., Clemenceau, S., Granat, O., Marsault, C. and Baulac, M. (1997) Temporal lobe epilepsy with varying severity: MRI study of 222 patients. Neuroradiology, 39: 788-796.
40. Margerison, J.H. and Corsellis, J.A.N. (1966) Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes. Brain, 89: 499-530.
41. Marsh, L., Morrell, M.J., Shear, P.K., Sullivan, E.V., Freeman, H., Marie, A., Lim, K.O. and Pfefferbaum, A. (1997) Cortical and hippocampal volume deficits in temporal lobe epilepsy. Epilepsia, 38: 576-587.
42. Mathern, G.W., Babb, T.L., Vickrey, B.G., Melendez, M. and Pretorius, J.K. (1995) The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy. Brain, 118: 105-118.
43. Mikkonen, M., Soininen, H., Kälviäinen, R., Tapiola, T., Ylinen, A., Vapalahti, M., Paljärvi, L. and Pitkänen, A. (1998) Remodeling of neuronal circuitries in human temporal lobe epilepsy: Increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex. Ann. Neurol., 44: 923-934.
44. Miller, L.A., McLachlan, R.S., Bouwer, M.S., Hudson, L.P. and Munoz, D.G. (1994) Amygdalar sclerosis: Preoperative indicators and outcome after temporal lobectomy. J. Neurol. Neurosurg. Psychiatry, 57: 1099-1105.
45. Mouritzen Dam, A. (1980) Epilepsy and neuron loss in the hippocampus. Epilepsia, 21: 617-629.
46. Nohria, V., Lee, N., Tien, R.D., Heinz, E.R., Smith, J.S., DeLong, G.R., Skeen, M.B., Resnick, T.J., Crain, B. and Lewis, D.V. (1994) Magnetic resonance imaging evidence of hippocampal sclerosis in progression: A case report. Epilepsia, 35: 1332-1336.
47. O'Brien, T.J., So, E.L., Meyer, F.B., Parisi, J.E. and Jack, C.R. (1999) Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy. Ann. Neurol., 45: 526-529.
48. Pitkänen, A., Tuunanen, J., Kälviäinen, R., Partanen, K. and Salmenperä, T. (1998) Amygdala damage in experimental and human temporal lobe epilepsy. Epilepsy Res., 32: 233-253.
49. Quigg, M., Bertram, E.H. and Jackson, T. (1997) Longitudinal distribution of hippocampal atrophy in mesial temporal lobe epilepsy. Epilepsy Res., 27: 101-110.
50. Salmenperä, T., Kälviäinen, R., Partanen, K. and Pitkänen, A. (1999) Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy. Seizure, 9: 208-215.
51. Salmenperä, T., Kälviäinen, R., Partanen, K. and Pitkänen, A. (2001) Hippocampal and amygdaloid damage in partial epilepsy: A cross-sectional MRI study of 241 patients. Epilepsy Res., 46: 69-82.
52. Saukkonen, A., Kälviäinen, R., Partanen, K., Vainio, P., Riekkinen, P. and Pitkänen, A. (1994) Do seizures cause neuronal damage? A MRI study in newly diagnosed and chronic epilepsy. NeuroReport, 6: 219-223.
53. Semah, F., Picot, M.C., Adam, C., Broglin, D., Arzimanoglou, A., Bazin, B., Cavalcanti, D. and Baulac, A. (1998) Is the underlying cause of epilepsy a major prognostic factor for recurrence?. Neurology, 51: 1256-1262.
54. Sloviter, R.S. (1983) 'Epileptic' brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies. Brain Res. Bull., 10: 675-697.
55. Soininen, H., Partanen, K., Pitkänen, A., Vainio, P., Hänninen, T., Hallikainen, M., Koivisto, K. and Riekkinen Sr., P. (1994) Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment. Neurology, 44: 1660-1668.
56. Spencer, S.S., McCarthy, G. and Spencer, D.D. (1993) Diagnosis of medial temporal lobe seizure onset: Relative specificity and sensitivity of quantitative MRI. Neurology, 43: 2117-2124.
57. Sutula, T.P. and Hermann, B. (1999) Progression in mesial temporal lobe epilepsy. Ann. Neurol., 45: 553-556.
58. Tasch, E., Cendes, F., Li, L.M., Dubeau, F., Andermann, F. and Arnold, D.L. (1999) Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy. Ann. Neurol., 45: 568-576.
59. Theodore, W.H., Bhatia, S., Hatta, J., Fazilat, S., DeCarli, C., Bookheimer, S.Y. and Gaillard, W.D. (1999) Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures. Neurology, 52: 132-136.
60. Tien, R.D. and Felsberg, G.J. (1995) The hippocampus in status epilepticus: Demonstration of signal intensity and morphologic changes with sequential fast spin-echo MR imaging. Radiology, 194: 249-256.
61. Trenerry, M.R., Jack Jr., C.R., Sharbrough, F.W., Cascino, G.D., Hirschorn, K.A., Marsh, W.R., Kelly, P.J. and Meyer, F.B. (1993) Quantitative MRI hippocampal volumes: Association with onset and duration of epilepsy, and febrile convulsions in temporal lobectomy patients. Epilepsy Res., 15: 247-252.
62. VanLandingham, K.E., Heinz, E.R., Cavazos, J.E. and Lewis, D.V. (1998) Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions. Ann. Neurol., 43: 413-426.
63. Van Paesschen, W., Connelly, A., Johnson, C.L. and Duncan, J.S. (1996) The amygdala and intractable temporal lobe epilepsy: A quantitative magnetic resonance imaging study. Neurology, 47: 1021-1031.
64. Van Paesschen, W., Connelly, A., King, M.D., Jackson, G.D. and Duncan, J.S. (1997a) The spectrum of hippocampal sclerosis: A quantitative magnetic resonance imaging study. Ann. Neurol., 41: 41-51.
65. Van Paesschen, W., Duncan, J.S., Stevens, J.M. and Connelly, A. (1997b) Etiology and early prognosis of newly diagnosed partial seizures in adults: A quantitative hippocampal MRI study. Neurology, 49: 753-757.
66. Van Paesschen, W., Revesz, T., Duncan, J.S., King, M.D. and Connelly, A. (1997c) Quantitative neuropathology and quantitative magnetic resonance imaging of the hippocampus in temporal lobe epilepsy. Ann. Neurol., 42: 756-766.
67. Van Paesschen, W., Duncan, J.S., Stevens, J.M. and Connelly, A. (1998) Longitudinal quantitative hippocampal magnetic resonance imaging study of adults with newly diagnosed partial seizures: One-year follow-up results. Epilepsia, 39: 633-639.
68. Watson, C., Andermann, F., Gloor, P., Jones-Gotman, M., Peters, T., Evans, A., Olivier, A., Melanson, D. and Leroux, G. (1992) Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology, 42: 1743-1750.
69. Wieser, H.G., Engel, J. Jr., Williamson, P.D., Babb, T.L. and Gloor, P. (1993) Surgically remediable temporal lobe syndromes. In: J. Engel Jr. (Ed.), Surgical Treatment of the Epilepsies. Raven Press, New York, pp. 49-63.
70. Wieshmann, U.C., Woermann, F.G., Lemieux, L., Free, S.L., Bartlett, P.A., Smith, S.J.M., Duncan, J.S., Stevens, J.M. and Shorvon, S.D. (1997) Development of hippocampal atrophy: A serial magnetic resonance imaging study in a patient who developed epilepsy after generalized status epilepticus. Epilepsia, 38: 1238-1241.