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Volumn 24, Issue SUPPL. D, 2002, Pages 127-128

Pharmaco-electroencephalography and pharmacokinetic-pharmacodynamic modeling in drug development: Focus on preclinical steps

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CLOBAZAM; FLUNITRAZEPAM; MIDAZOLAM; OXAZEPAM; PSYCHOTROPIC AGENT; TIAGABINE;

EID: 0036458046     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (4)

References (14)
  • 1
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    • Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "Wooden Shoe" paradigm
    • Breimer, D.D., Danhof, M. Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "Wooden Shoe" paradigm. Clin Pharmacokinet 1997, 32: 259-67.
    • (1997) Clin Pharmacokinet , vol.32 , pp. 259-267
    • Breimer, D.D.1    Danhof, M.2
  • 2
    • 0030842321 scopus 로고    scopus 로고
    • Analysis of drug-receptor interactions in vivo: A new approach in pharmacodynamic modelling
    • Van der Graaf, P.H., Danhof, M. Analysis of drug-receptor interactions in vivo: A new approach in pharmacodynamic modelling. Int J Clin Pharmacol Ther 1997, 35: 442-6.
    • (1997) Int J Clin Pharmacol Ther , vol.35 , pp. 442-446
    • Van der Graaf, P.H.1    Danhof, M.2
  • 5
    • 0031936583 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: Correlation with the interaction at the mu-opioid receptor
    • Cox, E.H., Kerbusch, T., Van der Graaf, P.H., Danhof, M. Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: Correlation with the interaction at the mu-opioid receptor. J Pharmacol Exp Ther 1998, 284: 1095-103.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 1095-1103
    • Cox, E.H.1    Kerbusch, T.2    Van der Graaf, P.H.3    Danhof, M.4
  • 7
    • 0032912419 scopus 로고    scopus 로고
    • The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat EEG model
    • Cox, E.H., Langemeijer, M.W.E., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat EEG model. Anesthesiology 1999, 90: 535-44.
    • (1999) Anesthesiology , vol.90 , pp. 535-544
    • Cox, E.H.1    Langemeijer, M.W.E.2    Gubbens-Stibbe, J.M.3    Muir, K.T.4    Danhof, M.5
  • 8
    • 0032927364 scopus 로고    scopus 로고
    • Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: Midazolam and alpha-OH-midazolam
    • Tuk, B., van Oostenbruggen, M.F., Herben, V.M.M., Mandema. J.W., Danhof, M. Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: Midazolam and alpha-OH-midazolam. J Pharmacol Exp Ther 1999, 289: 1067-74.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1067-1074
    • Tuk, B.1    Van Oostenbruggen, M.F.2    Herben, V.M.M.3    Mandema, J.W.4    Danhof, M.5
  • 9
    • 0033501265 scopus 로고    scopus 로고
    • Application of a combined "effect compartment/indirect response model" to the central nervous system effect of tiagabine in the rat
    • Cleton, A., de Greef, H.J.M.M., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. Application of a combined "effect compartment/indirect response model" to the central nervous system effect of tiagabine in the rat. J Pharmacokinet Biopharm 1999, 27: 301-23.
    • (1999) J Pharmacokinet Biopharm , vol.27 , pp. 301-323
    • Cleton, A.1    De Greef, H.J.M.M.2    Edelbroek, P.M.3    Voskuyl, R.A.4    Danhof, M.5
  • 10
    • 0033462181 scopus 로고    scopus 로고
    • Stereoselective central nervous system effects of the R-and S-isomers of the GABA uptake blocker N-(4,4-di-(3-methylthien-2-yl)but-3-enyl)nipecotic acid in the rat
    • Cleton, A., de Greef, H.J.M.M., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. Stereoselective central nervous system effects of the R-and S-isomers of the GABA uptake blocker N-(4,4-di-(3-methylthien-2-yl)but-3-enyl)nipecotic acid in the rat. Br J Pharmacol 1999, 128: 1651-8.
    • (1999) Br J Pharmacol , vol.128 , pp. 1651-1658
    • Cleton, A.1    De Greef, H.J.M.M.2    Edelbroek, P.M.3    Voskuyl, R.A.4    Danhof, M.5
  • 11
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    • Mechanism-based pharmacokinetic-pharmacodynamic modeling of the EEG effects of concentration-dependent hysteresis and biphasic EEG effects of alphaxalone in rats
    • Visser, S.A.G., Smulders, C.J.G.M., Reijers, B.P.R., van der Graaf, P.H., Peletier, L.A., Danhof, M. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the EEG effects of concentration-dependent hysteresis and biphasic EEG effects of alphaxalone in rats. J Pharmacol Exp Ther 2002, 302: 1158-67.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.