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1
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0030890279
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Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "Wooden Shoe" paradigm
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Breimer, D.D., Danhof, M. Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "Wooden Shoe" paradigm. Clin Pharmacokinet 1997, 32: 259-67.
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(1997)
Clin Pharmacokinet
, vol.32
, pp. 259-267
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Breimer, D.D.1
Danhof, M.2
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2
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0030842321
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Analysis of drug-receptor interactions in vivo: A new approach in pharmacodynamic modelling
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Van der Graaf, P.H., Danhof, M. Analysis of drug-receptor interactions in vivo: A new approach in pharmacodynamic modelling. Int J Clin Pharmacol Ther 1997, 35: 442-6.
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(1997)
Int J Clin Pharmacol Ther
, vol.35
, pp. 442-446
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Van der Graaf, P.H.1
Danhof, M.2
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5
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0031936583
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Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: Correlation with the interaction at the mu-opioid receptor
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Cox, E.H., Kerbusch, T., Van der Graaf, P.H., Danhof, M. Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: Correlation with the interaction at the mu-opioid receptor. J Pharmacol Exp Ther 1998, 284: 1095-103.
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(1998)
J Pharmacol Exp Ther
, vol.284
, pp. 1095-1103
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Cox, E.H.1
Kerbusch, T.2
Van der Graaf, P.H.3
Danhof, M.4
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6
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0033840732
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Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following β-funaltrexamine-induced mu-opioid receptor knockdown in vivo
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Garrido, M., Gubbens-Stibbe, J.M.. Tukker, H.J., Cox, E.H., Drabbe, J., von Freitag, J., Künzel, D., Ijzerman, A., Danhof, M., Van der Graaf, P.H. Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following β-funaltrexamine-induced mu-opioid receptor knockdown in vivo. Pharm Res 2000, 17: 653-9.
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(2000)
Pharm Res
, vol.17
, pp. 653-659
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Garrido, M.1
Gubbens-Stibbe, J.M.2
Tukker, H.J.3
Cox, E.H.4
Drabbe, J.5
Von Freitag, J.6
Künzel, D.7
Ijzerman, A.8
Danhof, M.9
Van der Graaf, P.H.10
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7
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0032912419
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The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat EEG model
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Cox, E.H., Langemeijer, M.W.E., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat EEG model. Anesthesiology 1999, 90: 535-44.
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(1999)
Anesthesiology
, vol.90
, pp. 535-544
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Cox, E.H.1
Langemeijer, M.W.E.2
Gubbens-Stibbe, J.M.3
Muir, K.T.4
Danhof, M.5
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8
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0032927364
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Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: Midazolam and alpha-OH-midazolam
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Tuk, B., van Oostenbruggen, M.F., Herben, V.M.M., Mandema. J.W., Danhof, M. Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: Midazolam and alpha-OH-midazolam. J Pharmacol Exp Ther 1999, 289: 1067-74.
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(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 1067-1074
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Tuk, B.1
Van Oostenbruggen, M.F.2
Herben, V.M.M.3
Mandema, J.W.4
Danhof, M.5
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9
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0033501265
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Application of a combined "effect compartment/indirect response model" to the central nervous system effect of tiagabine in the rat
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Cleton, A., de Greef, H.J.M.M., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. Application of a combined "effect compartment/indirect response model" to the central nervous system effect of tiagabine in the rat. J Pharmacokinet Biopharm 1999, 27: 301-23.
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(1999)
J Pharmacokinet Biopharm
, vol.27
, pp. 301-323
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Cleton, A.1
De Greef, H.J.M.M.2
Edelbroek, P.M.3
Voskuyl, R.A.4
Danhof, M.5
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10
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0033462181
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Stereoselective central nervous system effects of the R-and S-isomers of the GABA uptake blocker N-(4,4-di-(3-methylthien-2-yl)but-3-enyl)nipecotic acid in the rat
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Cleton, A., de Greef, H.J.M.M., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. Stereoselective central nervous system effects of the R-and S-isomers of the GABA uptake blocker N-(4,4-di-(3-methylthien-2-yl)but-3-enyl)nipecotic acid in the rat. Br J Pharmacol 1999, 128: 1651-8.
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(1999)
Br J Pharmacol
, vol.128
, pp. 1651-1658
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Cleton, A.1
De Greef, H.J.M.M.2
Edelbroek, P.M.3
Voskuyl, R.A.4
Danhof, M.5
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11
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0036721222
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Mechanism-based pharmacokinetic-pharmacodynamic modeling of the EEG effects of concentration-dependent hysteresis and biphasic EEG effects of alphaxalone in rats
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Visser, S.A.G., Smulders, C.J.G.M., Reijers, B.P.R., van der Graaf, P.H., Peletier, L.A., Danhof, M. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the EEG effects of concentration-dependent hysteresis and biphasic EEG effects of alphaxalone in rats. J Pharmacol Exp Ther 2002, 302: 1158-67.
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(2002)
J Pharmacol Exp Ther
, vol.302
, pp. 1158-1167
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Visser, S.A.G.1
Smulders, C.J.G.M.2
Reijers, B.P.R.3
Van der Graaf, P.H.4
Peletier, L.A.5
Danhof, M.6
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