5-Methylcytosine is present in the 5' flanking region of Ha-ras in mouse liver and increases with ageing

International Journal of Cancer

Volumn 72, Issue 3, 1997, Pages 491-497

  Counts, Jennifer L ^a,c   Kaznowski, Janice M ^a   Michael Mcclain, R ^b   Goodman, Jay I ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA CONTENT; DNA METHYLATION; LIVER CANCER; MALE; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL;

5-METHYLCYTOSINE; AGING; ANIMALS; CYTOSINE; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA METHYLATION; DNA RESTRICTION ENZYMES; GENES, RAS; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION;

EID: 0030790723     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970729)72:3<491::AID-IJC18>3.0.CO;2-F     Document Type: Article

References (28)

1. BORRELLO, M.G., PIEROTTI, M.A., TAMBORINI, E., BIASSONI, D., RIZZETTI, M.G., PILOTTI, S. and DELLA-PORTA, G., DNA methylation of coding and non-codina regions of the human H-RAS gene in normal and tumor tissues. Oncogene, 7, 269-275 (1992).
2. BROWN, K., BAILLEUL, B., RAMSDEN, M., FEE, F., KRUMLAUF, R. and BALMAIN, A., Isolation and characterization of the 5′ flanking region of the mouse c-Ha-ras gene. Mol. Carcinogenesis, 1, 161-170 (1988).
3. BUCHMANN, A., BAUER-HOFMANN, R., MAHR, J., DRINKWATER, N.R., LUZ, A. and SCHWARZ, M., Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis. Proc. nat. Acad. Sci. (Wash.), 88, 911-915 (1991).
4. CLARK, S.J., HARRISON, J. and FROMMER, M., CpNpG methylation in mammalian cells. Nature (Genet.), 10, 20-27 (1995).
5. COONEY, C.A., Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging. Growth Develop. Aging, 57, 261-273 (1993).
6. 1, C3H/He and C57BL/6 mouse liver. Cancer Lett., 75, 129-136 (1993).
7. COUNTS, J.L. and GOODMAN, J.I., Hypomethylation of DNA: a nongeno- toxic mechanism involved in tumor promotion. Toxicology Lett., 82/83, 663-672 (1995a).
8. COUNTS, J.L. and GOODMAN, J.I., Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell, 83, 13-15 (1995b).
9. DRAGAN, Y.P., SARGENT. L., XU, Y.-D., XU, Y.-H. and PITOT, H.C., The initiation-promotion-progression model of rat hepatocarcinogenesis. Proc. Soc. exp. Biol. Med., 202, 16-24 (1993).
10. GARDINER-GARDEN, M. and FROMMER, M., CpG islands in vertebrate genomes. J. mol. Biol., 196, 261-282 (1987).
11. GHAZI, H., GONZALES, F.A. and JONES, P.A., Methylation of CpG-island-containing genes in human sperm, fetal and adult tissues. Gene, 114, 203-210 (1992).
12. GONZALEZ-ZULUETA, M., BENDER, C.M., YANG, A.S., NGUYEN, T., BEART, R.W., VAN-TORNOUT, J.M. and JONES, P.A., Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55, 4531-4535 (1995).
13. ISSA, J.-P., VERTINO, P.M., BOEHM, C.D., NEWSHAM, I.F. and BAYLIN, S.B., Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc. nat. Acad. Sci. (Wash.), 93, 11757-11762 (1996).
14. JENTSCH, S., GÜNTHERT, U. and TRAUTNER, T.A., DNA methyltransferases affecting the sequence 5′CCGG. Nucleic Acids Res., 9, 2753-2759 (1981).
15. KIARIS, H. and SPANDIDOS, D.A., Mutations of ras genes in human tumors. Int. J. Oncol., 7, 413-121 (1995).
16. KORCH, C. and HAGBLOM, P., In-vivo-modified gonococcal plasmid pJD1. A model system for analysis of restriction enzyme sensitivity to DNA modifications. Enrop. J. Biochem., 161, 519-524 (1986).
17. LI, E., BESTOR, T.H. and JAENISCH, R., Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell, 69, 915-926 (1992).
18. MANN, M.B. and SMITH, H.O., Specificity of HpaII and HaeIII DNA methylases. Nucleic Acids Res., 4, 4211-4221 (1977).
19. MARONPOT, R.R., FOX, T., MALARKEY, D.E. and GOLDSWORTHY, T.L., Mutation in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors. Toxicology, 101, 125-156 (1995).
20. MAYOL, X., NEAL, G.E., DAVIES, R., ROMERO, A. and DOMINGO, J., Ethinyl estradiol-induced cell proliferation in rat liver. Involvement of specific populations of hepatocytes. Carcinogenesis, 13, 2381-2388 (1992).
21. MCCLELLAND, M. and NELSON, M., Effect of site-specific methylation on DNA modification methyltransferases and restriction endonucleases. Nucleic Acids Res., 20 (Suppl.), 2145-2157 (1992).
22. NEADHS, R., BETZ, N.A., SHENG, X. and PELLING, J.C., Transient expression of the cloned mouse c-Ha-ras 5′ upstream region in transfected primary SENCAR mouse keratinocytes demonstrates its power as a promoter element. Mol. Carcinogenesis, 4, 369-375 (1991).
23. ONO, T., TAKAHASHI, N. and OKADA, S., Age-associated changes in DNA methylation and mRNA level of the c-myc gene in spleen and liver of mice. Mutation Res., 219, 39-50 (1989).
24. 1 mouse liver tumors. Mol. Carcinogenesis, 9, 155-166 (1994).
25. SINGER-SAM, J., GRANT, M., LEBON, J.M., OKUYAMA, K., CHAPMAN, V., MONK, M. and RIGGS, A.D., Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol. Cell Biol., 10, 4987-4989 (1990).
26. 1 mouse liver tumors. J. Toxicol. environ. Health, 34, 367-384 (1991).
27. WILSON, V.L., SMITH, R.A., MA, S. and CUTLER, R.G., Genomic 5-methyl-deoxycytidine decreases with age. J. biol. Chem., 262, 9948-9951 (1987).
28. WOODCOCK, D.M., CROWTHER, P.J. and DIVER, W.P., The majority of methylated deoxycytidines in human DNA are not in the CpG dinucleotide. Biochem. biophys. Res. Comm., 145, 888-894 (1987).