Comparative toxicokinetic/toxicodynamic study of rubber antioxidants, 2-mercaptobenzimidazole and its methyl substituted derivatives, by repeated oral administration in rats

Archives of Toxicology

Volumn 76, Issue 12, 2002, Pages 682-691

  Sakemi, Kazue ^a   Ito, Rieno ^a   Umemura, Takashi ^a   Ohno, Yasuo ^a   Tsuda, Mitsuhiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

2 Mercapto 4 methylbenzimidazole; 2 Mercapto 5 methylbenzimidazole; 2 Mercaptobenzimidazole; Rats; Repeated oral administration; Thioureylenes; Thyroid toxicity; Toxicokinetics toxicodynamics

Indexed keywords

2 BENZIMIDAZOLETHIOL DERIVATIVE; ANTIOXIDANT; BENZIMIDAZOLE DERIVATIVE; CHEMICAL COMPOUND; CORN OIL; LACTOPEROXIDASE; METHYL GROUP; RUBBER; 2 BENZIMIDAZOLETHIOL; 2 MERCAPTOMETHYLBENZIMIDAZOLE; 2-MERCAPTOBENZIMIDAZOLE; 2-MERCAPTOMETHYLBENZIMIDAZOLE;

AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; DESULFURIZATION; DRUG INHIBITION; DRUG POTENCY; FEEDING; ISOMER; LIQUID CHROMATOGRAPHY; MALE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; THYROID DISEASE; TOXICOKINETICS; URINALYSIS; ANIMAL; BODY WEIGHT; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; GERMFREE ANIMAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; ORAL DRUG ADMINISTRATION; ORGAN SIZE; PATHOLOGY; THYROID GLAND; WISTAR RAT;

CHAETODON; RATTUS NORVEGICUS; ZEA MAYS;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; AREA UNDER CURVE; BENZIMIDAZOLES; BODY WEIGHT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; LACTOPEROXIDASE; LIVER; MALE; ORGAN SIZE; RATS; RATS, WISTAR; SPECIFIC PATHOGEN-FREE ORGANISMS; THYROID GLAND;

EID: 0036449293     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0392-0     Document Type: Article

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