Comparative toxicokinetic study of rubber antioxidants, 2- mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats

Journal of Toxicological Sciences

Volumn 24, Issue 5, 1999, Pages 399-405

  Sakemi, Kazue ^a   Usami, Makoto ^a   Mitsunaga, Katsuyoshi ^a   Ohno, Yasuo ^a   Tsuda, Mitsuhiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

2 Mercaptomethylbenzimidazole; 2 Mercaptobenzimidazole; Acute toxicity; Rats; Rubber antioxidant; Toxicokinetics

Indexed keywords

2 BENZIMIDAZOLETHIOL DERIVATIVE; ANTIOXIDANT; RUBBER;

ACUTE TOXICITY; ANIMAL MODEL; ARTICLE; ATAXIA; COMA; MALE; NONHUMAN; RAT; THYROID GLAND; TOXICOKINETICS; URINARY EXCRETION;

ANIMALIA; ATAXIA; RATTUS NORVEGICUS;

EID: 0033388433     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.24.5_399     Document Type: Article

References (9)

1. Dahlem, A.M., Allerheilingen, S.R. and Vodicnik, M.J. (1995): Concomitant toxicokinetics: Techniques for and interpretation of exposure data obtained during the conduct of toxicology studies. Toxicol. Pathol. 23, 170-178.
2. El Dareer, S.M., Kalin, J.R., Tillery, K.F. and Hill, D.L. (1984): Disposition of 2-mercaptobenzimidazole in rats dosed orally or intravenously. J. Toxicol. Environ. Health, 14, 595-604.
3. Gaworski, C.L., Aranyi, C., Vana, S., Rajendran, N., Abdo, K., Levine, B.S. and Hall III. A. (1991): Prechronic inhalation studies of 2-mercaptobenzimidazole (2-MBI) in F344/N rats. Fundament. Appl. Toxicol., 16, 161-171.
4. International Conference on Harmonization (1994): Note for guidance on toxicokinetics: The assessment of systemic exposure in toxicity studies.
5. Isama, K., Momma, J., Kaniwa, M. and Nakamura, A. (1998): Structure-activity relationships for skin sensitization potential of 2-mercaptobenzimidazole and its methyl derivatives. Environ. Dermatol., 5, 26-33.
6. Jannsen, F.W., Young, E.M., Kirkman, S.K., Sharma, R.N. and Ruelius, H.W. (1981): Biotransformation of the immunomodulator,3-(p-chlorophenyl)-2,3-dihydro-3-hydroxythiazolo{2,3a} benzimidazole-2-acetic acid, and its relationship to thyroid toxicity. Toxicol. Appl. Pharmacol., 59, 355-363.
7. Kawasaki,Y., Umemura, T., Saito, M., Momma, J., Matsushim, Y., Sekiguchi, H., Matsumoto, M., Sakemi, K., Isama, K., Inoue, T., Kurokawa, Y. and Tsuda, M. (1998): Toxicity study of a rubber antioxidant, 2-mercaptobenzimidazole, by repeated oral dose administration to rats. J. Toxicol. Sci., 23, 53-68.
8. Saitoh, M., Umemura, T., Kawasaki, Y., Momma, J., Matsushima, Y., Sakemi, K., Isama, K., Kitajima, S., Ogawa, Y., Hasegawa, R., Suzuki, T., Hayashi, M., Inoue, T., Ohno, Y., Sofuni, T., Kurokawa, Y. and Tsuda, M. (1999): Toxicity study of a rubber antioxidant, mixture of 2-mercaptomethylbenzimidazoles, by repeated oral administration to rats. Food. Chem. Toxicol., 37, 777-787.
9. Wright, D.S., Rose, S.E. and MacDonald, J.R. (1993): Toxicokinetics of drugs acting on the central nervous system: In Drug Toxicokinetics (Welling, P.G. and De La Iglesia, F.A., eds.), pp. 325-361, Marcel Dekker, Inc., New York.