Toxicity study of a rubber antioxidant, mixture of 2-mercaptomethylbenzimidazoles, by repeated oral administration to rats

Food and Chemical Toxicology

Volumn 37, Issue 7, 1999, Pages 777-787

  Saitoh, M ^a   Umemura, T ^a   Kawasaki, Y ^a   Momma, J ^a   Matsushima, Y ^a   Sakemi, K ^a   Isama, K ^b   Kitajima, S ^a   Ogawa, Y ^a   Hasegawa, R ^a   Suzuki, T ^a   Hayashi, M ^a   Inoue, T ^a   Ohno, Y ^a   Sofuni, T ^a   Kurokawa, Y ^a   Tsuda, M ^a  

^a Biol Safety Res Ctr   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Antithyroid toxicity; Rat; Repeated oral administration; Rubber antioxidant; Thioureylene compound

Indexed keywords

2 BENZIMIDAZOLETHIOL DERIVATIVE; ANTIOXIDANT; ANTITHYROID AGENT; THYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEEDING; FEMALE; MALE; NONHUMAN; OCCUPATIONAL TOXICOLOGY; ORAL DRUG ADMINISTRATION; ORGAN WEIGHT; RAT; THYROID DISEASE; THYROID WEIGHT;

ANIMALS; ANTIOXIDANTS; BENZIMIDAZOLES; BONE MARROW CELLS; DIET; EATING; FEMALE; LETHAL DOSE 50; MALE; MICRONUCLEUS TESTS; MUTAGENS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; RATS; RATS, WISTAR; RUBBER;

RATTUS NORVEGICUS; ZEA MAYS;

EID: 0032764316     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00058-7     Document Type: Article

References (21)

1. Airaudo C.B., Gayte-Sorbier A., Momburg R., Laurent P. Leaching of antioxidants and vulcanization accelerators from rubber closures into drug preparations. Journal of Biomaterials Science, Polymer Edition. 1:1990;231-241.
2. Deorge D.R. Mechanism-based inhibition of lactoperoxidase by thiocarbamide goitrogens. Biochemistry. 25:1986;4724-4728.
3. Doy L., Rohein P.S. Rat plasma lipoproteins and apolipoproteins in experimental hypothyroidism. Journal of Lipid Research. 22:1981;287-296.
4. Gaworski C.L., Aranyi C., Vana S., Rajendran N., Abdo K., Levine B.S., Hall Iii A. Prechronic inhalation studies of 2-mercaptobenzimidazole (2-MBI) in F344/N rats. Fundamental and Applied Toxicology. 16:1991;161-171.
5. Hayashi M., Morita T., Kodama Y., Sofuni T., Ishidate M. Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutation Research. 245:1990;245-249.
6. Haynes R. C. (1990) Thyroid and antithyroid drugs. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, ed. A. G. Gilmann, T. W. Rall, A. S. Nies and P. Taylor, 8th edn, pp. 1361-1383. Pergamon Press, New York.
7. IARC (1974) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 7, Ethylenethiourea, pp. 45-52. International Agency for Research on Cancer, Lyon.
8. Isama K., Momma J., Kaniwa M., Nakamura A. Structure-activity relationships for skin sensitization potential of 2-mercaptobenzimidazole and its methyl derivatives. Environmental Dermatology. 5:1998;26-33.
9. Kanazu K. (1980) Blood and hemopoietic organs. In Histopathology of Experimental Animals, ed. Enomoto et al., pp. 362-379. Soft Science, Tokyo (in Japanese).
10. Janssen F.W., Young E.M., Kirkman S.K., Sharma R.N., Ruelius H.W. Biotransformation of the immunomodulator, 3-(p-chlorophenyl)2,3-dihydro-3-hydroxythiazolo{2,3a}benzimidazole-2-acetic acid, and its relationship to thyroid toxicity. Toxicology and Applied Pharmacology. 59:1981;355-363.
11. Kawasaki Y., Umemura T., Saito M., Momma J., Matsushima Y., Sekiguchi H., Matsumoto M., Sakemi K., Isama K., Inoue T., Kurokawa Y., Tsuda M. Toxicity study of a rubber antioxidant, 2-mercaptobenzimidazole, by repeated oral dose administration to rats. Journal of Toxicological Sciences. 23:1998;53-68.
12. Levin S., Semler D., Ruben Z. Effects of two weeks of feed restriction on some common toxicologic parameters in Sprague-Dawley rats. Toxicologic Pathology. 21:1993;1-14.
13. Lorke D. A new approach to practical acute toxicity testing. Archives of Toxicology. 54:1983;275-287.
14. McClain R. The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid gland neoplasia. Toxicologic Pathology. 17:1989;294-306.
15. Norford D.C., Meuten D.J., Culien J.M., Collins J.J. Pituitary and thyroid gland lesions induced by 2-mercaptobenzimidazole (2-MBI) inhalation in male Fisher-344 rats. Toxicologic Pathology. 21:1993;456-464.
16. Paynter O.E., Burin G.J., Jaeger R.B., Gregorio C.A. Goitrogens and thyroid follicular cell neoplasia: Evidence for a threshold process. Regulatory Toxicology and Pharmacology. 8:1988;102-119.
17. Rotstein D.M., Kertesz D.J., Walker K.A.M., Swinney D.C. Stereoisomers of ketoconazole: Preparation and biological activity. Journal of Medicinal Chemistry. 35:1992;2818-2825.
18. Ruggiero F.M., Gnoni G.V., Quagliariello E. Effect of hypothyroidism on the lipid composition of rat plasma and erythrocyte membranes. Lipids. 22:1987;148-151.
19. Taurog A. The mechanism of action of the thioureylene antithyroid drugs. Endocrinology. 98:1976;1031-1046.
20. Visser T.J., van Overmeeren E., Fekkes D., Docter R., Hennemann G. Inhibition of iodothyronine 5′-deiodinase by thioureylenes: Structure-activity relationship. FEBS Letters. 103:1979;314-318.
21. Yamazaki M., Noguchi Y., Tanda M., Shintani S. Statistical methods appropriate for general toxicological studies in rats. Algorithms for multiple comparisons of treatment groups with control. Journal of the Takeda Research Laboratory. 40:1981;163-187.