Severe acute pancreatitis is related to increased early urinary levels of the activation peptide of pancreatic phospholipase A2

Pancreatology

Volumn 2, Issue 6, 2002, Pages 535-542

  Mayer, Jens M ^a   Raraty, Michael ^b   Slavin, John ^b   Kemppainen, Esko ^c   Fitzpatrick, John ^d   Hietaranta, Antti ^c   Puolakkainen, Pauli ^c   Beger, Hans G ^a   Neoptolemos, John P ^b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Necrosis, pancreatitis; Organ complications, pancreatitis; Pancreatitis; Pathophysiology, pancreatitis; Phospholipase A2; Zymogen activation

Indexed keywords

ACTIVATION PEPTIDE; ENZYME PRECURSOR; PEPTIDE; PHOSPHOLIPASE A2; TRYPSINOGEN; TRYPSINOGEN ACTIVATION PEPTIDE; UNCLASSIFIED DRUG; OLIGOPEPTIDE; PHOSPHOLIPASE A; PROPHOSPHOLIPASE A2;

ACUTE PANCREATITIS; ADULT; AGED; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVATION; EUROPE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; SAMPLING; TIME; URINALYSIS; ACUTE DISEASE; ADULT RESPIRATORY DISTRESS SYNDROME; FEMALE; HOSPITALIZATION; MALE; MIDDLE AGED; PANCREATITIS; PATHOPHYSIOLOGY; PROGNOSIS; URINE;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ENZYME PRECURSORS; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; OLIGOPEPTIDES; PANCREATITIS; PHOSPHOLIPASES A; PROGNOSIS; PROSPECTIVE STUDIES; RESPIRATORY DISTRESS SYNDROME, ADULT; SEVERITY OF ILLNESS INDEX;

EID: 0036440594     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000066098     Document Type: Article

References (50)

1. Whitcomb D: Early trypsinogen activation in acute pancreatitis. Gastroenterology 1999;116: 770-772.
2. Pfützer RH, Barmada MM, Brunskill AP, Finch R, Hart PS, Neoptolemos J, Furey WF, Whitcomb D: SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 2000;119:615-623.
3. Grady T, Mah'Moud T, Otani S, Rhee M, Lerch MM, Gorelick S: Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am J Physiol 1998;275: G1010-G1017.
4. Gudgeon AM, Heath DI, Hurley P, Jehanli A, Patel G, Wilson C, Shenkin A, Austen BM, Imrie CW, Hermon Taylor J: Trypsinogen activation peptide assays in the early prediction of severity of acute pancreatitis. Lancet 1990;335: 4-8.
5. Neoptolemos J, Kemppainen E, Mayer J, Raraty MGT, Slavin J, Fitzpatrick JM, Beger HG, Puolakkainen P: A multicentre study of early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide. Lancet 2000;355:1955-1960.
6. Rinderknecht H: Activation of pancreatic zymogens. Dig Dis Sci 1986;31:314-321.
7. Rinderknecht H: Pancreatic secretory enzymes; in Go LW, et al (eds): The Exocrine Pancreas: Biology, Pathobiology and Diseases. New York, Raven Press, 1986, pp 163-183.
8. 2 in acute pancreatitis: An experimental study in rats. Gut 1997;40:386-392.
9. 2 activation using an immunoassay for the free activation peptide DSGISPR. Ann Clin Biochem 1991;28:497-503.
10. 2 activation peptides in the rapid early prediction of trauma outcome: A preliminary report. Injury 1991;22:219-222.
11. 2 propeptide in acute lung injury. Lancet 1994;344:1472-1473.
12. Heath DI, Cruickshank A, Gudgeon AM, Jehanli A, Shenkin A, Imrie CW: The relationship between pancreatic enzyme release and activation and the acute-phase protein response in patients with acute pancreatitis. Pancreas 1995;10:347-353.
13. Mayer J, Rau B, Siech M, Beger HG: Local and systemic zymogen activation in human acute pancreatitis. Digestion 2000;62:164-170.
14. Bradley E: A clinically based classification system for acute pancreatitis: Summary of the International Symposium on Acute Pancreatitis. Arch Surg 1993;128:586-590.
15. Larvin M, McMahon MJ: APACHE-II score for assessment and monitoring of acute pancreatitis. Lancet 1989;ii:201-205.
16. Wilson C, Heath D, Imrie C: Prediction in outcome of acute pancreatitis: A comparative study of APACHE II, clinical assessment and multiple factor scoring systems. Br J Surg 1990; 77:1260-1264.
17. Ranson JHC, Rifkind KM, Roses DF, Fink SD, Eng K, Spencer FC: Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974;139:69-81.
18. 2 propetide immunoreactivity is released from activated granulocytes. Clin Biochem 1995;28:1-7.
19. Beck JR, Shultz EK: The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 1986; 110:13-20.
20. Hurley P, Cook A, Austen B, Hermon Taylor J: Antibodies to trypsinogen activation peptides recognize both Ca-dependent and Ca-independent epitopes. Biochem Soc Trans 1988;16:337-338.
21. Hurley P, Cook A, Jehanli A, Austen B, Hermon Taylor J: Development of radioimmunoassays for free tetra-L-aspartyl-L-lysine trypsinogen activation peptides (TAP). J Immunol Methods 1988;111:195-203.
22. Tenner S, Fernandez del Castillo C, Warshaw A, Steinberg W, Hermon Taylor J, Valenzuela J, Hariri M, Hughes M, Banks P: Urinary trypsinogen activation peptide predicts severity in patients with acute pancreatitis. Int J Pancreatol 1997;21:105-110.
23. Gorelick FS, Otani T: Mechanisms of intracellular zymogen activation; in Neoptolemos JP (ed): Clinical Gastroenterology. London, Baillière Tindall, 1999, pp 227-237.
24. Appelros S, Thim L, Borgstrom A: Activation peptide of carboxypeptidase B in serum and urine in acute pancreatitis. Gut 1998;42:97-102.
25. 2 in relation to systemic inflammatory response syndrome (SIRS) and systemic complications in severe acute pancreatitis. Pancreas 1999;18:385-391.
26. 2 in patients with infected pancreatic necrosis in acute pancreatitis. Pancreas 1998; 17:272-277.
27. 2 in human serum. Clin Chem 1992;38:1824-1829.
28. 2 in serum from patients with acute pancreatitis. Clin Chem 1988;34:1052-1054.
29. 2 in human acute pancreatitis. Gastroenterology 1989;97:1521-1526.
30. 2 in serum samples from patients with severe acute pancreatitis. Gut 1993;34:1133-1136.
31. 2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk. Clin Chem Lab Med 2002;40: 293-297.
32. 2 levels in patients with acute pancreatitis. Res Commun Mol Pathol Pharmacol 2001;109:159-164.
33. 2 isoforms in acute pancreatitis. Ann Surg 2001;233:204-212.
34. 2 in the liver in acute pancreatitis. Scand J Gastroenterol 2001;36:1217-1221.
35. Bialek R, Willemer S, Arnold R, Adler G: Evidence of intracellular activation of serine proteases in acute cerulein-induced pancreatitis in rats. Scand J Gastroenterol 1991;26:190-196.
36. Appelros S, Borgstrom A: Studies on the turnover of procarboxypeptidase B, active enzyme and the activation peptide in pig. Biol Chem 1998;379:893-898.
37. Luthen R, Niederau C, Grendell JH: Intrapancreatic zymogen activation and levels of ATP and glutathione during caerulein pancreatitis in rats. Am J Physiol 1995;268:G592-G604.
38. Winslet MC, Hall C, London NJM, Neoptolemos JP: Relationship of diagnostic serum amylase to aetiology and prognosis in acute pancreatitis. Gut 1992;33:982-986.
39. 2, amylase, lipase, and urinary amylase activities in relation to the severity of acute pancreatitis. Eur J Surg 1997;163:915-922.
40. Millson CE, Charles K, Poon P, Macfie J, Mitchell CJ: A prospective study of serum pancreatic elastase-1 in the diagnosis and assessment of acute pancreatitis. Scand J Gastroenterol 1998;33:664-668.
41. Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussing J: Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000;106:773-781.
42. Brady M, Christmas S, Sutton R, Neoptolemos JP, Slavin J: Cytokines and acute pancreatitis; in Neoptolemos JP (ed): Clinical Gastroenterology. London, Baillière Tindall, 1999, pp 265-289.
43. Bhatia M, Brady M, Zagorski J, Christmas SE, Campbell F, Neoptolemos JP, Slavin J: Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury. Gut 2000;47:838-844.
44. Bhatia M, Brady M, Kang YK, Costello E, Newton DJ, Christmas SE, Neoptolemos JP, Slavin J: MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation. Am J Physiol 2002; 282:G77-G85.
45. Shokuhi S, Bhatia M, Christmas S, Sutton R, Neoptolemos JP, Slavin J: Levels of the chemokines growth-related oncogene alpha and epithelial neutrophil-activating protein 78 are raised in patients with severe acute pancreatitis. Br J Surg 2002;89:566-572.
46. Raraty M, Ward J, Sutton R, Neoptolemos JP, Petersen O: Abnormal cytosolic calcium induces enzyme activation and vacuolization in mouse pancreatic acinar cells. Proc Natl Acad Sci USA 2000;97:13126-13131.
47. Bhatia M, Wallig MA, Hofbauer B, Lee HS, Frossard JL, Steer ML, Saluja AK: Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis. Biochem Biophys Res Commun 1998;246:476-483.
48. Kemppainen E, Hedström J, Puolakkainen P, Halttunen J, Sainio V, Haapiainen R, Kivilaakso E, Stenman UH: Increased serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography induced pancreatitis with high accuracy. Gut 1997;41:690-695.
49. Hedström J, Sainio V, Kemppainen E, Haapiainen R, Kivilaakso E, Schröder T, Leinonen J, Stenman UH: Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: Clinical study in consecutive patients. BMJ 1996;313: 333-337.
50. Mayer JM, Raraty M, Slavin J, Kemppainen E, Fitzpatrick J, Hietaranta A, Puolakkainen P, Beger HG, Neoptolemos JP: Serum amyloid A is a better early predictor of severity than C-reactive protein in acute pancreatitis. Br J Surg 2002;89:163-171.