The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli

European Journal of Biochemistry

Volumn 269, Issue 22, 2002, Pages 5564-5571

  Adams, Hendrik ^a   Scotti, Pier A ^b,c   De Cock, Hans ^a   Luirink, Joen ^b   Tommassen, Jan ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c INSTITUT EUROPÉEN DE CHIMIE ET BIOLOGIE   (France)

Author keywords

Outer membrane protein; Sec translocon; SecB; Signal recognition particle; Translocation

Indexed keywords

GLYCINE; MEMBRANE PROTEIN; MUTANT PROTEIN; PROTON; SECRETORY PROTEIN; SIGNAL RECOGNITION PARTICLE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CROSS LINKING; DNA HELIX; DNA STRAND BREAKAGE; ESCHERICHIA COLI; GENE MUTATION; GENE TRANSLOCATION; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLYCINE; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; PORINS; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL RECOGNITION PARTICLE; TIME FACTORS; TRANSCRIPTION, GENETIC;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0036439069     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03262.x     Document Type: Article

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