Affinity and kinetics of the interactions between an αβ T-cell receptor and its superantigen and class II-MHC/peptide ligands

Molecular Immunology

Volumn 34, Issue 6, 1997, Pages 493-503

  Khandekar, Sanjay S ^a   Brauer, Pamela P ^a   Naylor, Jerome W ^a   Chang, Hsiu Ching ^b   Kern, Petra ^b   Newcomb, John R ^a   Leclair, Kenneth P ^a   Stump, Holly S ^a   Bettencourt, Brian M ^a   Kawasaki, Ernest ^a   Banerji, Julian ^a   Profy, Albert T ^a   Jones, Barry ^a  

^a Procept Inc   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Binding constants; Leucine zipper; MHC; SPR; Superantigens; TCR

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SUPERANTIGEN;

ANIMAL CELL; ANTIGEN SPECIFICITY; ANTIGENICITY; ARTICLE; BINDING AFFINITY; BIOSENSOR; GENE SEQUENCE; LEPIDOPTERA; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE ACTIVATION;

ANIMALS; BACULOVIRIDAE; BIOSENSING TECHNIQUES; CELLS, CULTURED; HISTOCOMPATIBILITY ANTIGENS CLASS II; KINETICS; LIGANDS; LYMPHOCYTE ACTIVATION; MOTHS; PEPTIDES; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT FUSION PROTEINS; SOLUBILITY; SPECTRUM ANALYSIS; SUPERANTIGENS;

ANIMALIA; INSECTA; LEPIDOPTERA; MURINAE; STAPHYLOCOCCUS AUREUS;

EID: 18744436304     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00044-8     Document Type: Article

References (58)

1. Ashwell J. D. and Klausner R. D. (1990) Genetic and mutational analysis of the T-cell antigen receptor. A. Rev. Immun. 8, 139-167.
2. Avery A. C., Markowitz J. S., Grusby M. J., Glimcher L. H. and Cantor H. (1994) Activation of T cells by superantigen in class II-negative mice. J. Immun. 153, 4853-4861.
3. Becker M. L. B., Near R., Mudgett-Hunter M., Margolies M. N., Kubo R. T., Kaye J. and Hedrick S. M. (1989) Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell 58, 911-921.
4. Benoist C. D., Mathis D. J., Williams II V. E. and McDevitt H. O. (1983) The murine I-A α-chains Eα and A α show a surprising degree of sequence homology. Proc. natn. Acad. Sci. U.S.A. 80, 534-538.
5. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the protein-dye binding. Analyt. Biochem. 72, 248-254.
6. Chang H.-C., Bao Z. Z., Yao Y., Tse A. G. D., Goyarts E. C., Madsen M., Kawasaki E., Brauer P., Sacchettini J. C., Nathenson S. G. and Reinherz E. L. (1994) A general method of facilitating heterodimeric pairing between two proteins: application to expression of α and β T cell receptor extracellular segments. Proc. natn. Acad. Sci. U.S.A. 91, 11408-11412.
7. Corr M., Slanetz A. E., Boyd L. F., Jelonek M. T., Khilko S., Al-Ramadi B. K., Kim Y. S., Maher S. E., Bothwell A. L. M. and Margulies D. H. (1994) T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity. Science 265, 946-949.
8. Deckhut A. M., Chien Y.-H., Blackman M. A. and Woodland D. L. (1994) Evidence for a functional interaction between the β chain of major histocompatibility complex class II and the T cell receptor α chain during recognition of a bacterial superantigen. J. Exp. Med. 180, 1931-1935.
9. Engel I., Ottenhoff M. and Klausner R. D. (1992) High-efficiency expression and solubilization of functional T cell antigen receptor heterodimers. Science 256, 1318-1321.
10. Fremont D. H., Rees W. A. and Kozono H. (1996) Biophysical studies of T-cell receptors and their ligands. Curr. Opin. Immun. 8, 93-100.
11. Gregoire C., Rebai N., Schweiguth F., Necker A., Mazza G., Auphan N., Millward A., Schmitt-Verhulst A.-M. and Malissen B. (1991) Engineered secreted T-cell receptor heterodimers. Proc. natn. Acad. Sci. U.S.A. 88, 8077-8081
12. Harlow, E. and Lane, D. (1988) In Antibodies: a Laboratory Manual. Cold Spring Harbor Laboratory, New York.
13. Haskins K., Portas M., Bergman B., Lafferty K. and Bradley B. (1989) Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc. natn. Acad. Sci. U.S.A. 86, 8000-8004.
14. Hilyard K. L., Reyburn H., Chung S., Bell J. I. and Strominger J. L. (1994) Binding of soluble natural ligands to a soluble human T-cell receptor fragment produced in Escherichia coli. Proc. natn. Acad. Sci. U.S.A. 91, 9057-9061.
15. Hong S.-C., Waterbury G., Janeway C. A. Jr. (1996) Different superantigens interact with distinct sites in the V β domain of a single T cell receptor. J. Exp. Med. 183, 1437-1446.
16. Janeway C. A. Jr., Yagi J., Conrad P. J., Katz B., Jones B., Vroegop S. and Buxser S. (1989) T-cell responses to MIs and to bacterial proteins that mimic its behavior. Immun. Rev. 107, 61-88.
17. Johnsson B., Lofas S. and Lindqvist G. (1991) Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Analyt. Biochem. 198, 268-277.
18. Kanagawa O. (1989) Antibody-mediated activation of T-cell clones as a method for screening hybridomas producing antibodies to the T cell receptor. J. Exp. Med. 170, 1513-1519.
19. Kappler J., White J., Kozono H., Clements J. and Marrack P. (1994) Binding of a soluble αβ T-cell receptor to superantigen/major histocompatibility complex ligands. Proc. natn. Acad. Sci. U.S.A. 91, 8462-8466.
20. Kaye J., Porcelli S., Tite J., Jones B. and Janeway C. A. Jr. (1983) Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J. Exp. Med. 158, 836-856.
21. Khandekar S. S., Bettencourt B. M., Kelley K. C. and Recny M. A. (1993) A simple and rapid method for the purification of GroEL, an Escherichia coli homolog of the heat shock protein 60 family of molecular chaperonins. Protein Expression and Purification 4, 580-584.
22. Kozono H., Parker D., White J., Marrack P. and Kappler J. (1995) Multiple binding sites for bacterial superantigens on soluble class II molecules. Immunity 3, 187-196.
23. Kozono H., White J., Clements J., Marrack P. and Kappler J. (1994) Production of soluble MHC class II proteins with covalently bound single peptides. Nature 369, 151-154.
24. Kubo R. T., Born W., Kappler J. W., Marrack P. and Pigeon M. (1989) Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immun. 142, 2736-2742.
25. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277, 680-682.
26. Lyons D. S., Lieberman S. A., Hampl J., Boniface J. J., Chien Y.-H., Berg L. J. and Davis M. M. (1996) A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5, 53-61.
27. Malchiodi E. L., Eisenstein E., Fields B. A., Ohlendorf D. H., Schlievert P. M., Karjalainen K. and Mariuzza R. A. (1995) Superantigen binding to a T cell receptor β chain of known three-dimensional structure. J. Exp. Med. 182, 1833-1845.
28. Malmqvist M. (1993) Surface plasmon resonance for detection and measurement of antibody-antigen affinity and kinetics. Curr. Biol. 5, 282-286.
29. Margulies D. H. (1996) An affinity for learning. Nature 381, 558-559.
30. Marrack P. and Kappler J. (1990) The Staphylococcal enterotoxins and their relatives. Science 248, 705-711.
31. Mathis D. J., Benoist C. D., Williams II V. E., Kanter M. R. and McDevitt H. O. (1983) The murine E α immune response gene. Cell 32, 745-754.
32. Matsudaira P. (1987) Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J. Biol. Chem. 262, 10035-10038.
33. Matsui K., Boniface J. J., Reay P. A., Schild H., Groth F. and Davis M. M. (1991) Low affinity interaction of peptide-MHC complexes with T cell receptors. Science 254, 1788-1791.
34. k complexes: correlation of dissociation rate with T-cell responsiveness. Proc. natn. Acad. Sci. U.S.A. 91, 12862-12866.
35. McKeever U., Khandekar S., Newcomb J., Naylor J., Gregory P., Brauer P., Jesson M., Bettencourt B., Burke E., Alderson A., Banerji J., Haskins K. and Jones B. (1996) Immunization with soluble BDC2.5 T cell receptor-immunoglobulin (TCR-IgG1) chimeric protein: antibody specificity and protection of non obese diabetic (NOD) mice against adoptive transfer of diabetes by maternal immunization. J. Exp. Med. 184, 1755-1768.
36. Merwe P. A. van der, Barclay A. N., Mason D. W., Davies E. A., Morgan B. P., Tone M., Krishnan A. K. C., Lanelli C. and Davis S. J. (1994) Human cell-adhesion molecule CD2 bind CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59. Biochemistry 33, 10149-10160.
37. Meuer S. C., Acuto O., Hercend T., Schlossman S. F. and Reinherz E. L. (1984) The human T-cell receptor. A. Rev. Immun. 2, 23-50.
38. Moebius U., Clayton L. K., Abraham S., Harrison S. C. and Reinherz E. L. (1992) The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure. J. Exp. Med. 176, 507-517.
39. Munir Alam S., Travers P. J., Wung J. L., Nasholds W., Redpath S., Jameson S. C. and Gascoigne N. R. (1996) T-cell-receptor affinity and thymocyte positive selection. Nature 381, 616-620.
40. + T cell epitopes. Eur. J. Immun. 21, 2851-2855.
41. O'Reilly D. R., Miller L. K. and Luckow V. A. (1992) In Baculovirus Expression Vector: a Laboratory Manual. W. H. Freeman, New York.
42. O'Shannessy D. J. (1994) Determination of kinetic rate and equilibrium binding constants for macromolecular interactions: a critique of the surface plasmon resonance literature. Curr. Biol. 5, 65-71.
43. O'Shea E. K., Lumb K. L. and Kim P. S. (1993) Peptide "Velcro": design of a heterodimeric coiled coil. Curr. Biol. 3, 658-667.
44. Pantoliano M. W., Bird R. E., Johnson S., Asel E. D., Dodd S. W., Wood J. F. and Hardman K. D. (1991) Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli. Biochemistry 30, 10117-10125.
45. k and T cell receptor Vα a haplotypes: determination with a V α2-specific monoclonal antibody. Eur. J. Immun. 22, 399-404.
46. Rice J. W., Rankl N. B., Gurganus T. M., Marr C. M., Barna J. B., Walters M. M. and Burns D. J. (1993) A comparison of large-scale Sf9 insect cell growth and protein production: stirred vessel vs. airlift. Biotechniques 15, 1015-1059.
47. Sadegh-Nasseri S. and Germain R. N. (1991) A role for peptide in determining MHC class II structure. Nature 0, 167-170.
48. Sayre P. H., Hussey R. E., Chang H.-C., Ciardelli T. L. and Reinherz E. L. (1989) Structural and binding analysis of a two domain extracellular CD2 molecule. J. Exp. Med. 169, 995-1009.
49. Scott C. A., Garcia K. C., Carbone F. R., Wilson I. A. and Teyton E. (1996) Role of chain pairing for the productivity of functional soluble IA major histocompatibility complex class II molecules. J. Exp. Med. 183, 2087-2095.
50. Seth A., Stern L. J., Ottenhoff T. H. H., Engel I., Owens M. J., Lamb J. R., Klausner R. D. and Wiley D. C. (1994) Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro. Nature 369, 324-327.
51. Stern L. J. and Wiley D. C. (1992) The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide. Cell 68, 465-477.
52. Stern L. J. and Wiley D. C. (1994) Antigenic peptide binding by class I and class II histocompatibility proteins. Curr. Biol. 2, 245-251.
53. Summers M. D. and Smith G. E. (1988) A manual of methods for baculovirus vectors and insect cell culture procedures. Texas Agriculatural Experimental Station Bulletin 1555, 10-39.
54. Sykulev Y., Brunmark A., Jackson M., Cohen R. J., Peterson P. and Eisen H. N. (1994) Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes. Immunity 1, 15-22.
55. Sykulev Y., Brunmark A., Tsomides T. J., Kageyama S., Jackson M., Peterson P. and Eisen H. N. (1994) High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. natn. Acad. Sci. U.S.A. 91, 11487-11491.
56. Valitutti S., Muller S., Cella M., Padovan E. and Lanzavecchia A. (1995) Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151.
57. Weber S., Traunecker A., Oliveri F., Gerhard W. and Karjalainen K. (1992) Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor. Nature 356, 793-796.
58. Woodland D. L. and Blackman M. A. (1993) How do T-cell receptors, MHC molecules and superantigens get together? Immun. Today 14, 208-211.