Absorption of biologically active peptide hormones from the small intestine of rat

Acta Physiologica Scandinavica

Volumn 176, Issue 3, 2002, Pages 203-213

  Wheeler, S ^a   Mcginn, B J ^b   Lucas, M L ^a   Morrison, J D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b Thistle Research   (United Kingdom)

Author keywords

Absorption; Cholic acid; Gastrin; Ileum

Indexed keywords

CHOLIC ACID; GASTRIN; PEPTIDE HORMONE;

ACID SECRETION; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONJUGATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; ILEUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE ABSORPTION; STOMACH ACID SECRETION; SYSTEMIC CIRCULATION;

ABSORPTION; ANIMALS; BLOOD PRESSURE; CHOLIC ACID; GASTRIC ACID; GASTRINS; ILEUM; INFUSIONS, PARENTERAL; INJECTIONS, INTRAVENOUS; INTESTINAL MUCOSA; MALE; RATS; RATS, WISTAR; TETRAGASTRIN;

EID: 0036428621     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.2002.01006.x     Document Type: Article

References (34)

1. Baker, R.D. & Searle, G.W. 1960. Bile salt absorption at various levels of the rat small intestine. Proc Soc Exp Biol Med 105, 521-523.
2. Bendayan, M., Ziv, E., Ben-Sasson, R., Bar-On, H. & Kidron, M. 1990. Morpho-cytochemical and biochemical evidence for insulin absorption by the rat ileal epithelium. Diabetologica 33, 197-204.
3. British National Formulary 2001. Royal Pharmaceutical Society, London.
4. Burkoth, T.L., Bellhouse, B.J., Hewson, G., Longridge, D.J., Muddle, A.G. & Sarphie, D.F. 1999. Transdermal and transmucosal powdered drug delivery. Crit Rev Therap Drug Carr Sys 16, 331-384.
5. Chan, W.C. & White, P.D. 2000. Fmoc Solid Phase Peptide Synthesis - A Practical Approach. Oxford University Press, Oxford.
6. Dakka, T., Dumoulin, V., Chayvialle, J.A. & Cuber, J.C. 1995. Cholyltaurine absorption by the isolated vascualrly perfused rat small bowel. Digestion 56, 165-170.
7. Damge, C., Vranckx, H., Balschmidt, P. & Couvreur, P. 1997. Poly (alky cyanoacrylate) nanospheres for oral administration of insulin. J Pharmaceut Sci 86, 1403-1409.
8. Davenport, H.W. 1977. Physiology of the Digestive Tract, 4th Edn. Year Book Medical Publishers Inc, Chicago, IL.
9. Haas, S., Miura-Fraboni, J., Zavala, F., Murata, K., Leone-Bay, A. & Santiago, N. 1996. Oral immunization with a model protein entrapped in microspheres prepared from derivatized α-amino acids. Vaccine 14, 785-791.
10. Holt, P.R. 1964. Intestinal absorption of bile salts in the rat. Am J Physiol 207, 1-7.
11. Kramer, W. & Wess, G. 1995. Modified Bile Acid Conjugates, and their use as Pharmaceuticals. United States Patent 5,462,933. US Patent & Trademark Office, Washington, DC.
12. Kramer, W., Wess, G., Neckermann, G. et al. 1994. Intestinal absorption of peptides by coupling to bile acids. J Biol Chem 269, 10621-10627.
13. Krchnak, V., Vagner, J. & Lebl, M. 1988. Noninvasive monitoring of solid-phase peptide synthesis by acid-base indicator. Int J Pept Prot Res 32, 415-416.
14. Lack, L. & Weiner, I.M. 1961. In vitro absorption of bile salts by small intestine of rats and guinea pigs. Am J Physiol 200, 313-317.
15. Lack, L. & Weiner, I.M. 1966. Intestinal bile salt transport: Structure-activity relationships and other properties. Am J Physiol 210, 1142-1152.
16. Layer, P., Holst, J.J., Grandt, D. & Goebell, H. 1995. Ileal release of glucagon-like peptide-1 (GLP-1). Associated inhibition of gastric acid secretion. Digest Dis Sci 40, 1074-1082.
17. Lichteberger, L.M., Nelson, A.A. & Graziani, L.A. 1986. Amine trapping: A physical explanation for the inhibitory effect of gastric acidity on the post-prandial release of gastrin. Studies on rats and dogs. Gastroenterology 90, 1223-1231.
18. Mathlowitz, E., Jacob, J.S., Jong, Y.S. et al. 1997. Biologically erodable microspheres as potential oral drug delivery systems. Nature 386, 410-414.
19. Matthews, D.M. & Adibi, S.A. 1976. Peptide absorption. Gastroenterology 71, 151-161.
20. McGinn, B.J. 1996. Peptide synthesis. In: N.C. Price (ed.) Proteins Labfax, pp. 139-154. Bios Scientific Publishers and Academic Press, London.
21. Morley, J.S., Tracey, H.J. & Gregory, R.A. 1965. Structure-relationships in the active C-terminal tetrapeptide sequence of gastrin. Nature 207, 1356-1359.
22. Muranishi, S., Murakami, M., Hashidzume, M., Yamada, K., Tajima, S. & Kiso, Y. 1992. Trials of lipid modification of peptide hormones for intestinal delivery. J Contr Release 19, 179-188.
23. Namba, M., Matsuyama, T., Itoh, H., Imai, Y., Horie, H. & Tarui, S. 1986. Inhibition of pentagastrin-stimulated gastric acid secretion by intra-ileal administration of bile and elevation of plasma concentrations of gut glucagon-like immunoreactivity in anaesthetized dogs. Regul Pept 15, 121-128.
24. Playoust, M.R. & Isselbacher, K.J. 1964. Studies of the transport and metabolism of conjugated bile salts by intestinal mucosa. J Clin Invest 43, 467-476.
25. Ritschel, W.A. 1991. Microemulsions for improved peptide absorption from gastrointestinal tract. Meth Find Exp Clin Pharmacol 13, 205-220.
26. Roberts, P.A., Burney, J.D., Black, K.W. & Zaloga, G.P. 1999. Effect of chain length on absorption of biologically active peptides from the gastrointestinal tract. Digestion 60, 332-337.
27. Skyler, J.S., Cefalu, W.T., Kourides, I.A. et al. 2001. Efficacy of inhaled insulin in type 1 diabetes mellitus: A randomised proof-of-concept study. Lancet 357, 331-335.
28. 3 by liver targeting with cholic acid. Biochem Pharmacol 43, 1969-1974.
29. Swaan, P.W., Szoka, F.C. & Ørie, S. 1996. Use of intestinal and hepatic bile acid transporters for drug delivery. Adv Drug Del Rev 20, 59-82.
30. Swaan, P.W., Hillgren, K.M., Szoka, F.C. & Ørie, S. 1997. Enhanced transepithelial transport of peptides by conjugation to cholic acid. Bioconj Chem 8, 520-525.
31. Trier, J.S. 1991. Structure and function of intestinal M cells. Gastroenterol Clin N Am 20, 531-547.
32. Walsh, J.H. 1994. Gastrin. In: J.H. Walsh & G.J. Dockray (eds) Gut Peptides: Biochemistry and Physiology, pp. 75-121. Raven Press, New York.
33. Weiner, I.M. & Lack, I. 1967. Bule salt absorption; enterohepatic circulation. In: C.F. Code (ed.) Handbook of Physiology - Alimentary Canal III, pp. 1439-1455. American Physiological Society, Washington, DC.
34. Wheeler, S., Eardley, J.E.L., McNulty, K.F., Sutcliffe, C.P. & Morrison, J.D. 1997. An investigation into the relative merits of pituitary adenylate cyclase-activating polypeptide (PACAP-27) and vasoactive intestinal polypeptide as vagal neurotransmitters in exocrine pancreas of rats. Exp Physiol 82, 729-747.