Oral immunization with a model protein entrapped in microspheres prepared from derivatized α-amino acids

Vaccine

Volumn 14, Issue 8, 1996, Pages 785-791

  Haas, Susan ^a   Miura Fraboni, Judy ^a   Zavala, Fidel ^b   Murata, Kenichiro ^b   Leone Bay, Andrea ^a   Santiago, Noemi ^a  

^a Emisphere Technologies Inc   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Microspheres; Oral immunization; Ovalbumin

Indexed keywords

ALPHA AMINO ACID; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MICROSPHERE; OVALBUMIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030176041     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(95)00243-T     Document Type: Article

References (29)

1. 1 Walker, R.I. New strategies for using mucosal vaccination to achieve more effective immunization. Vaccine 1994, 12, 387-400
2. 2 McGhee, J.R., Mestecky, J., Dertzbaugh, M.T., Eldridge, J.H., Hirasawa, M. and Kiyono, H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 1992, 10, 75-88
3. 3 Hirabayashi, Y., Kurata, H., Funati, H. et al. Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination. Vaccine 1990, 8, 243-248
4. 4 Eldridge, J.H. et al. New advances in vaccine delivery systems. Sem. Hemat. 1993, 30, 16-25
5. 5 Orr, N., Robin, G., Cohen, D., Arnon, R. and Lowell, G.H. Immunogenicity and efficacy of oral or intranasal Shigella flexneri 2a and Shigella sonnei proteosome-lipopolysaccharide vaccines in animal models. Infect. Immun. 1993, 61, 2390-2395
6. 6 Mowat, A.Mcl., Maloy, K.J. and Donachie, A.M. Immune-stimulating complexes as adjuvants for inducing local and systemic immunity after oral immunization with protein antigens. Immunology 1993, 80, 527-534
7. 7 Challacombe, S.J. and Tomasi, T.B.Jr Systemic tolerance and secretory immunity after oral immunization. J. Exp. Med. 1980, 152, 1459-1472
8. 8 Sarubbi, D., Carozza, M., Frommer, E. et al. Seventh Int. Symp. Recent Advances Drug Delivery Systems, 1995, pp. 159-160
9. 9 Agarwal, R., Sarubbi, D., Maher, J. et al. Seventh Int. Symp. Recent Advances Drug Delivery Systems, 1995, pp. 151-152
10. 10 Leipold, H.R., Rivera, T.M., Rosado, C., Santiago, N., Variano, B.F. and Sarubbi, D.J. Seventh Int. Symp. Recent Advances Drug Delivery Systems, 1995, pp. 197-198
11. 11 Santiago, N., Rivera, T., Mayer, E. and Milstein, S. Proteinoid microspheres for the oral delivery of heparin. Proc. Int. Symp. Control. Rel. Bioact. Mater 1992, 19, 514-515
12. 12 Santiago, N., Haas, S., Baughman, R.A. Powell, M. and Newman, M.J. Vaccine Design: The Subunit and Adjuvant Approach June 4, 19961995, 413-438. Plenum Publishing Corporation, New York
13. 13 Santiago, N., Milstein, S., Rivera, T. et al. Oral immunization of rats with proteinoid microspheres encapsulating influenza virus antigens. Pharm. Res. 1993, 10, 1243-1247
14. 14 Lycke, N. and Holmgren, J. Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 1986, 59, 301-308
15. 15 Leone-Bay, A., Santiago, N., Achan, D. et al. N-Acylated a-amino acids as novel oral delivery agents for proteins. J. Med. Chem. 1995, 38, 4263-4269
16. 16 Elson, C.O., Ealding, L.O. and Lefkowitz, J. A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions. J. Immunol. Meth. 1984, 67, 101-108
17. 17 Franz, B., Stegemann, M. and Butler, J.E. Immunochemistry of Solid Phase Immunoassay June 4, 19961991, 277-284. CRC Press, Boca Raton, FL
18. 18 Tijssen, P. Practice and Theory of Enzyme Immunoassays June 4, 19961993. Elsevier Science Publishers, Amsterdam
19. 19 Forrest, B.D. Effects of sample processing on the measurement of specific intestinal IgA immune responses. Vaccine 1992, 10, 802-805
20. 20 Leone-Bay, A., Paton, D., McInnis, C. et al. Microsphere formation in a series of derivatized σ-amino acids. Properties, molecular modeling, and oral delivery of salmon calcitonin. J. Med. Chem. 1995, 38, 4257-4262
21. 21 Eldridge, J.H., Hammond, C.J., Muelbroek, J.A., Staas, J.K., Gilley, R.M. and Tice, T.R. Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's Patches. J. Cont. Rel. 1990, 11, 205-214
22. 22 Elson, C.O. and Ealding, W. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 1984, 133, 2892
23. 23 Rollwagen, F.M., Pacheco, N.D., Clements, J.D., Pavlovskis, O., Rollins, D.M. and Walker, R.I. Killed Campylobacter elicits immune response and protection when administered with an oral adjuvant. Vaccine 1993, 11, 1316-1320
24. 24 Kazanji, M. et al. Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeria falciformis in ISCOMs. Vaccine 1994, 12, 798-804
25. 25 Snider, D.P., Marshall, J.S., Perdue, M.H. and Liang, H. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 1994, 153, 647-657
26. 26 Santiago, N., Miura-Fraboni, J., Kumar, M., Leone-Bay, A., DeMorin, F. and Haas, S. Oral immunization with antigens and adjuvants co-encapsulated in derivatized a-amino acid microspheres. Proc. Int. Symp. Control. Rel. Bioact. Mater. 1995, 22, 576-577
27. 27 Langermann, S., Palaszynski, S., Sadzlene, A., Stover, C.K. and Koenig, S. Systemic and mucosal immunity induced by BCG vector expressing outer-surface protein A of Borrelia burgdorferi. Nature 1994, 372, 552-555
28. 28 O'Hagan, D.T., McGhee, J.R., Holmgren, J. et al. Biodegradable microparticles for oral immunization. Vaccine 1993, 11, 149-154
29. 29 Maloy, K.J., Donachie, A.M., O'Hagan, D.T. and Mowat, A.Mcl. Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-coglycolide) microparticles. Immunology 1994, 81, 661-667