Osteoarthritis II: Pathology and pathogenesis

Inflammopharmacology

Volumn 10, Issue 1-2, 2002, Pages 23-52

  Buchanan, W Watson ^a   Kean, Walter F ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; HYALIN; KERATIN; PROTEOGLYCAN;

CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; DISEASE SEVERITY; IMMUNE MEDIATED INJURY; INFLAMMATION; OSTEOARTHRITIS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SYNOVIAL FLUID; SYNOVITIS;

EID: 0036424519     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1163/156856002320751991     Document Type: Review

References (153)

1. Adams, M. E. and Brandt, K. D. (1991). Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transaction. J. Rheum. 18, 428-435.
2. Alaaeddine, N., Di Battista, J. A., Pelletier, J.-P., et al. (1997). Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha, J. Rheumatol. 24, 1985-1994.
3. 2 production by the anti-inflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways, Arthritis Rheum. 42, 710-718.
4. Ali, S. Y. and Rees, J. A. (1992). Microcrystal deposition in cartilage and in osteoarthritis, Bone Mineral. 17, 115-118.
5. Amin A. R. (1999). Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis, Osteoarthritis Cartilage 7, 392-394.
6. Attur, M. G., Mandar, D., Cipolletta, C., et al. (2000). Reversal of autocrine and paracrine effects of interleukin-1 (IL-1) in human arthritis by type II IL-1 decoy receptor: Potential for pharmacological intervention, J. Biol. Chem. 275, 40307-40315.
7. Bird, H. A. and Wright, V. (1981). Traumatic synovitis in a classical guitarist: A study of joint laxity, Ann. Rheum. Dis. 40, 161-163.
8. Blanco, F. J., Ochs, R. L., Schwarz, H., et al. (1995). Chondrocyte apoptosis induced by nitric oxide, Amer. J. Pathol. 146, 75-85.
9. Blanco, F. J., Guitian, R., Váázquez-Martul, E., et al. (1998). Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology, Arthritis Rheum. 41, 284-289.
10. Bollet, A. J. and Nance, J. L. (1966). Biochemical findings in normal and osteoarthritic cartilage. II Chondroitin sulfate concentration and chain length, water and ash contents, J. Clin. Invest. 45, 1170-1177.
11. Boyle, J. A. and Buchanan, W. W. (1971). Clinical Rheumatology. Blackwells, Oxford, UK.
12. Buchanan, W. W. and Smith, F. C. (1995). Understanding the normal joint: A basis for diagnosis, Canad. J. Diagnosis 12, 45-53.
13. Buchanan, W. W., Kean, W. F. and Palmer, D. G. (1987). The contribution of William Hunter (1718-1783) to the study of bone and joint disease, Clin. Rheumatol. 6, 489-503.
14. Buckwalter, J. A. and Cruess, R. (1991). Healing of musculoskeletaI tissues, in: Fractures in Adults, 3rd Edition, C. A. Rockwood, C. P. Green and R. W. Bucholz (Eds), 181-222. J. B. Lippincott, Philadelphia.
15. Bullough, P. C. (1992). The pathology of osteoarthritis, in: Osteoarthritis Diagnosis and Medical/Surgical Management, 2nd Edition, R. W. Moskowitz, D. S. Howell, V. M. Gouldberg and H. J. Mankin (Eds), pp. 39-69. W. B. Saunders, Philadelphia.
16. Bunch, T. W., Hunder, G. G., McDuffie, F. C., et al. (1974). Synovial fluid complement determination as a diagnostic aid in inflammatory joint disease, Mayo Clin. Proc. 49, 715-720.
17. Bywaters, E. G. L. (1937). Metabolism of joint tissues, J. Path. Bact. 44, 247-268.
18. Cheung, H. S., Ryan, L. M., Kozin, F., et al. (1980). Identification of collagen subtypes in synovial fluid sediments from arthritic patients, Amer. J. Med. 68, 73-79.
19. Cheung, H. S., Halverson, P. B. and McCarty, D. J. (1981). Release of collagenase neutral protease and prostaglandin from cultured mammalian synovial cells by hydroxyapatite and calcium pyrophosphate dehydrate crystals, Arthritis Rheum. 24, 1338-1344.
20. Chikanza, I. C., Roux-Lombard, P., Dayer, J. M., et al. (1993). Tumour necrosis factor soluble receptors behave as acute phase reactants following surgery in patients with rheumatoid arthritis, chronic osteomyelitis and osteoarthritis, Clin. Exp. Immunol. 92, 19-22.
21. Clark, I. M., Powell, L. K., Ramsay, S., et al. (1993). The measurement of collagenase, tissue inhibitor of metalloproteinases (TIMP) and collagenase-TIMP complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis, Arthritis Rheum. 36, 372-379.
22. Clark, A. G., Jordan, J. M., Vilim, V., et al. (1999). Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnson County Osteoarthritis Project, Arthritis Rheum. 42, 2356-2364.
23. Cooper, N. S., Soren, A., McCain, C., et al. (1981). Diagnostic specificity of synovial lesions, Human Pathology 12, 314-328.
24. Cope, A. P., Autarchy, D., Diehard, M., et al. (1992). Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases. Arthritis Rheum. 35, 1160-1169.
25. Crofford, L. J. (1997). COX-1 and COX-2 tissue expression: Implications and predictions, J. Rheumatol. 24, 15-19.
26. Crofford, L. J. (1998). Cyclooxygenase-1 and 2 in synovial tissues of arthritis patients. In: Clinical Significance and Potential of Selective Cox-2 Inhibitors, J. Vane and R. Botting (Eds). Kluwer William Harvey Press London, pp. 41-49.
27. Crofford L., Wilder, R. L. L., Ristimaki, A. P., et al. (1994). Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues: Effects of interleukin-1β, phorbol ester, and corticosteroids, J. Clin. Invest. 93, 1095-1101.
28. Dean, D. D. (1991). Proteinase-mediated cartilage degradation in osteoarthritis, Semin. Arthritis Rheum. 20 (Suppl. 2), 2-11.
29. Dean, D. D., Martel-Pelletier, J., Pelletier, J.-P., et al. (1989). Evidence for metalloproteinase and metalloproteinase inhibitor (TIMP) imbalance in human osteoarthritic cartilage, J. Clin. Invest. 84, 678-685.
30. Dean, G., Hoyland, J. A., Denton, J., et al. (1993). Mast cells in the synovium and synovial fluid in osteoarthritis, Brit. J. Rheumatol. 32, 671-675.
31. 133Xe) clearances correlated with clinical assessment in various Arthritudes and studies on the effect of intra-articularly administered hydrocortisone in rheumatoid arthritis, Clin. Sci. 38, 123-133.
32. Dieppe, P. A. (1981). Calcium phosphate crystal deposition and clinical subsets of osteoarthritis, in: Epidemiology of Osteoarthritis, J. G. Peyron (Ed.), pp. 71-80. Ciba-Geigy, Paris.
33. Dieppe, P. A., Crocker, P. R., Huskisson, E. C., et al. (1976). Apatite deposition disease: A new arthropathy, Lancet 2, 266-269.
34. Dieppe, P. A., Crocker, P. R., Corke, C. F., et al. (1979). Synovial fluid crystals, Quart. J. Med. 192, 533-553.
35. Doyle, D. V. (1982). Tissue calcification and inflammation in osteoarthritis, J. Pathol. 136, 199-216.
36. Eghtedari A. A., Bacon, P. A. and Collins, A. (1980). Immunoblasts in synovial fluid and blood in the rheumatic diseases, Ann. Rheum. Dis. 39, 318-322.
37. Essner, R., Rhoades, K., McBride, W. H., et al. (1989). IL-4 down-regulates IL-1 and TNF gene expression in human monocytes, J. Immunol. 142, 3857-3861.
38. Evans, C. H. (1981). Cellular mechanisms of hydrolysis enzyme release in proteoglycan, Semin. Arthritis Rheum. 11 (Suppl. 1), 93-95.
39. Evans, C. H., Mears, D. C. and McKnightr, J. L. (1981). A preliminary ferro graphic study of the wear particles in human synovial fluid, Arthritis Rheum. 24, 912-918.
40. Fahmy, N. R. A., Williams, J. A. and Noble, J. (1983). Medical pathology and osteoarthritis of the knee, J. Bone Joint Surg. 65B, 24-28.
41. Fam, A. G., Mordva-Pritzker, I., Purcell, C., et al. (1995). Acceleration of experimental lapine osteoarthritis by calcium pyrophosphate microcrystalline synovitis, Arthritis Rheum. 38, 201-210.
42. Farahat, M. N., Yanni, G., Poston, R., et al. (1993). Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis, Ann. Rheum. Dis. 52, 870-875.
43. Farrell, A. J., Blake, D. R., Palmer, R. M. J., et al. (1992). Increased concentration of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases, Ann. Rheum. Dis. 51, 1219-1222.
44. Firestein, G. S., Paine, M. M. and Littmann, B. H. (1991). Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intra-articular corticosteroids, Arthritis Rheum. 34, 1094-1105.
45. Gerster, J. C., Vischer, T. L. and Fallet, G. H. (1975). Destructive arthropathy in generalized osteoarthritis with articular chondrocalcinosis, J. Rheumatol. 2, 265-269.
46. Gerster, J. C. (1994). Intra-articular apatite crystal deposition as a predictor of erosive osteoarthritis of the fingers, J. Rheumatol. 21, 2164-2165.
47. Ghadially, F. N. (1978). Fine structure of joints, in: The Joints and Synovial Fluid, Vol. 1, L. Sokoloff (Ed.), pp. 105-168. Academic Press, New York.
48. Gibilisco, P. A., Schumacher, H. R., Hollander, J. L., et al. (1985). Synovial fluid crystals in osteoarthritis, Arthritis Rheum. 28, 511-515.
49. Gibilisco, P. A., Schumacher, H. R., Sieck, M., et al. (1982). Studies on the role of synovial fluid apatite and calcium pyrophosphate crystals in osteoarthritis, Arthritis Rheum. 25 (Suppl), 43.
50. Goldberg, R. L., Huff, J. P., Lenz, M. E., et al. (1991). Elevated plasma levels of hyaluronate in patients with osteoarthritis and rheumatoid arthritis, Arthritis Rheum. 34, 799-807.
51. Goldenberg, D. L., Egan, M. S. and Cohen, A. S. (1982). Inflammatory synovitis in degenerative joint disease, J. Rheumatol. 9, 204-209.
52. Gordon G. V., Villanueva, C., Schumacher, H. R., et al. (1984). Autopsy study correlating degree of osteoarthritis and evidence of articular calcification, J. Rheumatol. 11, 681-686.
53. Grabowski, P. S., Wright P. K., van't Hof R. J., et al. (1997). Immunolocalization of inducible nitric oxide synthase in synovium and cartilage of rheumatoid arthritis and osteoarthritis. Brit. J. Rheumatol. 36, 651-655.
54. Gunja-Smith, Z., Nagase, N. and Weresner, J. F. Jr. (1989). Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase, Biochem. J. 258, 115-119.
55. Halverson, P. B. and McCarty, D. J. (1976). Patterns of radiographic abnormalities associated with basic calcium phosphate and calcium pyrophosphate dehydrate crystal deposition in the knee, J. Bone Joint Surg. 58B, 94-101.
56. 2, Proc. Natl. Acad. Sci. USA 86, 3803-3807.
57. Hart, P. H., Ahern, M. J., Smith, M. D., et al. (1995). Comparison of the suppressive effects of interleukin-10 and interleukin-4 on synovial fluid macrophages and blood monocytes from patients with inflammatory arthritis, Immunology 84, 536-542.
58. Hashimoto, S., Setareh, M., Ochs, R. L., et al. (1997). Fas/Fas ligand expression and induction of apoptosis in chondrocytes, Arthritis Rheum. 40, 1749-1755.
59. Hashimoto, S., Takahashi, K., Amiel, D., et al. (1998). Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis, Arthritis Rheum. 41, 1266-1474.
60. Hasselbacher, P. (Editor) (1991). The Biology of the Joint. Clinics in the Rheumatic Diseases, Vol. 7, No. 1. W.B. Saunders, London.
61. Helbig, B., Gross, W. L., Borisch, B., et al. (1988). Characterization of synovial macrophages by monoclonal antibodies in rheumatoid arthritis and osteoarthritis, Scand. J. Rheumatol. 76 (Suppl.), 61-66.
62. Henderson, B. and Peltipher, E. R. (1989). Arthritogenic actions of recombinant IL-1 and tumor necrosis factor alpha in the rabbit: Evidence for synergistic interactions between cytokines in vivo, Clin. Exp. Immunol. 75, 306-310.
63. Hough, A. J. (1997). Pathology of osteoarthritis, in: Arthritis and Allied Conditions. A Textbook of Rheumatology, 13th Edition, Vol. 2, W. H. Koopman (Ed.), pp. 1945-1968. Williams and Wilkins, Baltimore, Maryland.
64. Howell, D. S., Treadwell, B. V. and Tripped S. B. (1992). Etiopathogenesis of osteoarthritis, in: Osteoarthritis Diagnosis and Medical/Surgical Management, 2nd Edition, R. W. Moskowitz, D. S. Howell, V. M. Goldberg and H. J. Mankin (Eds), Chap. 2, pp. 233-252. W. B. Saunders Co., Philadelphia.
65. Inérot, S., Heingard, D., Audell, L., et al. (1978). Articular cartilage proteoglycans in aging and osteoarthritis, Biochem. J. 169, 143-156.
66. Jasin, N. E. (1985). Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis, Arthritis Rheum. 28, 241-248.
67. Jovanovic, D., Pelletier, J.-P., Alaaeddine, N., et al. (1998). Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritic synovium and synovial fibroblasts, Osteoarthritis Cartilage 6, 40-49.
68. Kempson, G. E., Spivey, C. J., Swanson, S. A. V., et al. (1971). Patterns of cartilage stiffness on normal and degenerate human femoral heads, J. Biomech. 4, 597-609.
69. Kennedy, T. H., Plater-Zyberk, C., Partridge, T. A., et al. (1988). Morphometric comparisons of synovium from patients with osteoarthritis and rheumatoid arthritis, J. Clin. Path. 41, 847-852.
70. Kimball, E. S., Persico, F. J. and Vaught, J. L. (1988). Substance P, neurokinin A and neurokinin B induce generation of IL-1 like activity in P388D1 cells. Possible relevance to arthritic disease, J. Immunol. 141, 3564-3569.
71. Kinsella, T. D., Baum, J. and Ziff, M. (1970). Studies of isolated synovial lining cells of rheumatoid and non rheumatoid synovial membranes, Arthritis Rheum. 13, 734-753.
72. Kronheim, S. R., Mumma, A., Greenstreet, T., et al. (1992). Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor, Arch. Biochem. Biophys. 296, 698-703.
73. Landells, J. W. (1953). The bone cysts in osteoarthritis, J. Bone Jt. Surg. 35B, 643-649.
74. Lane, J. M., Brighton, C. T. and Minkowitz, B. T. (1977). Anaerobic and aerobic metabolism in articular cartilage, J. Rheumatol. 4, 334-342.
75. Lanzer, W. L. and Komenda, G. (1990). Changes in articular cartilage after meniscectomy, Clin. Orthop. 252, 41-48.
76. Lloyd-Roberts, G. C. (1953). The role of capsular changes in osteoarthritis of the hip joint, J. Bone Joint Surg. 35B, 627-642.
77. Lohmander, L. S. and Kimura, J. H. (1986). Biosynthesis of cartilage proteoglycan, in: Articular Cartilage Biochemistry, K. E. Keuttner, R. Schleyerbach and V. C. Hascall (Eds), pp. 93-110. Raven Press, New York.
78. Lohmander, L. S., Hoeffner, L. A. and Lark, M. W. (1993). Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis, Arthritis Rheum. 36, 181-189.
79. Lohmander, L. S., Saxne, T. and Heinegard, D. K. (1994). Release of cartilage oligomeric matrix protein (COMP) in to joint fluid after knee injury and in osteoarthritis, Ann. Rheum. 53, 8-13.
80. Luthra, H. S. (1998). Relapsing polychondritis, in: Rheumatology, 2nd Edition, J. H. Klippel and P. A. Dieppe (Eds), Vol. 1, Section 5, 27, pp. 1-4. Mosby International, London.
81. Mankin, H. J. and Radin, E. R. (1997). Structure and function of joints, in: Arthritis and Allied Disorders. A Textbook of Rheumatology, 13th Edition, W. H. Koopman (Ed.), Vol. 1, pp. 175-191. William and Wilkins, Baltimore.
82. Mankin, H. J. and Thrasher, A. Z. (1975). Water content and binding in normal and osteoarthritic human cartilage, J. Bone Joint Surg. 57A, 76-80.
83. Mankin, H. J., Dorfman, H. D., Lippiello, L., et al. (1971). Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II Correlation of morphology with metabolic data, J. Bone Joint Surg. 53A, 523-537.
84. Mankin, H. J. Mow, V. C., Buckwalter, J. A., et al. (1994). Form and function of articular cartilage, in: Orthopaedic Basic Science, S. Simon (Ed.), p. 1. American Academy of Orthopaedic Surgeons, Chicago.
85. Maroudas, A. (1975). Fluid transport in cartilage, Ann. Rheum. Dis. 34 (Suppl. 2), 77.
86. Maroudas, A. (1976). Balance between swelling pressure and collagen tension in normal and degenerative cartilage, Nature 260, 808-809.
87. Martel-Pelletier, J., McCollum, R., Fujimoto, N., et al. (1994). Excess of metalloproteinases over tissue inhibitor of metalloproteinase may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis, Lab. Invest. 70, 807-815.
88. Matucci-Cerinic, M., Lombardi, A., Leoncini, G., et al. (1993). Neutral endopeptidase (3,4,24,11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation?, Rheumatol. Int. 13, 1 -4.
89. McCarty, D. J., Halverson, P. B., Carrera, G. F., et al. (1981). 'Milwaukee shoulder' - Association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. I. Clinical aspects, Arthritis Rheum. 24, 464-473.
90. McDevitt, C. A. and Miller, R. R. (1989). Biochemistry, cell biology, and immunology of osteoarthritis, Curr. Opin. Rheumatol. 1, 303-314.
91. McDevitt, C. A. and Muir, H. (1976). Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dog, J. Bone Joint Surg. 58B, 94- 101.
92. McInnes, I. B., Leung, B. P., Field, M., et al. (1996). Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients, J. Exp. Med. 184, 1519-1524.
93. 4) in vitro, Ann. Rheum. Dis. 21, 45-50.
94. Meachim, G., Whitehorse, G. H., Peaky, R. D., et al. (1980) An investigation of radiological, clinical, and pathological correlations in osteoarthrosis of the hip, Clin. Radiol. 31, 565-574.
95. Menkes, C. J, Renaux, M., Laoussadi, S., et al. (1993). Substance P levels in the synovium and synovial fluid from patients with rheumatoid arthritis and osteoarthritis, J. Rheumatol. 20, 714-717.
96. Miller, M. D. and Brinker, M. R. (1992). Review of Orthopaedics, 3rd Edition, Section 2, pp. 40-61. W. B. Saunders Co., Philadelphia.
97. Mohtai, N., Smith, R. L., Schurman, D, J., et al. (1993). Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1, Clin. J. Invest. 92, 179- 185.
98. Muir, H. (1977). Molecular approach to the understanding of osteoarthrosis, Ann. Rheum, Dis. 36, 199-208.
99. Muir, H. (1986). Current and future trends in articular cartilage research and osteoarthritis, in: Articular Cartilage Biochemistry, K. E. Kuettner, R. Schleyenbach and R. Hascall (Eds), p. 423. Raven Press, New York.
100. Murphy, G., Cockett, M. I., Stephens, P. E., et al. (1987). Stromelysin is an activator of procollagenase, Biochem. J. 248, 265-268.
101. Murrell, G. A. C., Jang, D., Williams, R. J., et al. (1995). Nitric oxide activates metalloprotease enzymes in articular cartilage, Biochem. Biophys. Res. Commun. 206, 15-21.
102. Myers, S, L., Flusser, D., Brandt, K. D., et al. (1992), Prevalence of cartilage shards in synovium and their association with synovitis in patients, with early and end stage osteoarthritis, J. Rheumatol, 19, 1247-1251.
103. Nagase, H., Enghild, J. J., Suzuki, K., et al. (1990). Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl) mercuric acetate, Biochemistry 29, 5783-5789.
104. Okada Y, Konomi, H., Yada, T., et al. (1989). Degradation of type IX collagen by matrix metalloproteinase-3 (stromelysin) from human rheumatoid synovial cells, FEBS Lett. 244, 473-476.
105. Ollivierre, F., Gubler, V., Towle, C. A., et al. (1986). Expression of IL-1 gene in human and bovine chondrocytes: A mechanism for autocrine control of cartilage matrix degradation, Biochem. Biophys. Commun. 141, 904-911.
106. Palmoski, M. J. and Brandt, K, D. (1982). Immobilization of the knee prevents osteoarthritis after anterior cruciate ligament resection, Arthritis Rheum, 25, 1201-1208.
107. Pekin, T. J. and Zvaifler, N. J. (1964). Hemolytic complement in synovial fluid, J. Clin. Invest. 43, 1372-1382.
108. Pelletier, J.-P. and Martel-Pelletier, J. (1989). Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki model of osteoarthritis, Arthritis Rheum. 32, 181-193.
109. Pelletier, J.-P., Martel-Pelletier, J., Howell, D. S., et al. (1983a). Collagenase and collagenolytic activity in human osteoarthritic cartilage, Arthritis Rheum. 26, 63-68.
110. Pelletier, J.-P., Martel-Pelletier, J., Altman, R. D., et al. (1983b). Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond-Nuki dog model of osteoarthritis, Arthritis Rheum. 26, 866-874.
111. Pelletier, J.-P., Martel-Pelletier, J., Cloutier J. M., et al. (1987). Proteoglycan-degrading acid metalloprotease activity in human osteoarthritic cartilage, and the effect of intra-articular steroid injections, Arthritis Rheum. 30, 541-548.
112. Pelletier, J.-P., DiBattista, J. A., Roughley, P., et al. (1993). Cytokines and inflammation in cartilage degradation, in: Osteoarthritis, R. W. Moskowitz (Ed.), pp. 545-568. Rheumatic Disease Clinics of North America.
113. Pelletier, J.-P., Mineau, F., Raynauld, J. P., et al. (1994). Intra-articular injections with methylprednisolone acetate reduce osteoarthritis lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis, Arthritis Rheum. 37, 414-423.
114. Pelletier, J.-P., Mineau, F., Ranger P., et al. (1996). The increased synthesis of inducible nitric oxide inhibits IL-Ra synthesis by human articular chondrocytes: Possible role in osteoarthritis degradation, Osteoarthritis Cartilage 4, 77- 84.
115. Pelletier, J.-P., Martel-Pelletier, J. and Howell, D. S. (1997). Etiopathogenesis of osteoarthritis, in: Arthritis and Allied Conditions. A Textbook of Rheumatology, 13th Edition, Vol. 2, Chap. 8, pp. 1969-1984. Williams and Wilkins, Baltimore, Maryland.
116. Pelletier, J.-P., Janovic, D., Fernandes, J. C., et al. (1998). Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase, Arthritis Rheum. 41, 1275-1286.
117. Pelletier, J.-P., Martel-Pelletier, J., Abramson, S. B. (2001). Osteoarthritis, an Inflammatory Disease. Potential implication for the selection of new therapeutic targets, Arthritis Rheum. 44, 1237-1247.
118. Petersson, I. F., Boegard, T., Svensson, B., et al. (1998). Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint, Brit. J. Rheumatol. 37, 46-50.
119. Phillips, R. S. (1966). Phlebography in osteoarthritis of the hip, J. Bone Joint Surg. 48B, 280.
120. Pringle, J. A., Byers, P. D. and Brown, M. J. A. (1978). Immunofluorescence in osteoarthritis, Nature 274, 94.
121. Radin, E. R. (1976). Mechanical aspects of osteoarthritis, Bull. Rheum. Dis. 23, 862-865.
122. Radin, E. R. and Paul, I. L. (1970). Does cartilage compliance reduce skeletal impact loads? The relative force-attenuating properties of articular cartilages, synovial fluid, periarticular soft tissues and bone, Arthritis Rheum. 13, 139-144.
123. Radin, E. R. and Rose, R. M. (1986). Role of subchondral bone in the initiating and progression of cartilage damage, Clin. Orthop. 213, 34-40.
124. Reboul, P., Pelletier, J.-P., Tardif., G., et al. (1996). The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis, J. Clin. Invest. 97, May issue.
125. Rediske, J. J., Koehne, C. F., Zhang, B., et al. (1994). The inducible production of nitric oxide by articular cell types, Osteoarthritis Cartilage 2, 199-206.
126. Rhaney, K. and Lamb, D. W. (1955). The cysts of osteoarthritis of the hip. A radiological and pathological study, J. Bone Joint Surg. 37B, 663-675.
127. Saha, N., Moldovan, F., Tardif, G., et al. (1999). Interleukin-1-converting enzyme/caspase-1 in human osteoarthritic tissues: Localization and role in the maturation of interleukin-1 and interleukin-18, Arthritis Rheum. 42, 1577-1587.
128. Saklatvala, J. (1986). Tumor necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage, Nature 322, 547-549.
129. Schumacher, H. R., Gordon, G. and Paul, H. (1981). Osteoarthritis, crystal deposition and inflammation, Semin. Arthritis Rheum. 11 (Suppl.), 116-119.
130. Sharif, M., Saxne, T., Shepstone, L., et al. (1995). Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint, Brit. J. Rheumatol. 34, 306-310.
131. Sharif, M., Shepstone, L., Elson, C. J., et al. (2000). Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee, Ann. Rheum. Dis. 59, 71-74.
132. Shinmei, M., Okada, Y., Masuda, K., et al. (1990). The mechanism of cartilage degradation in osteoarthritic joints, Semin. Arthritis Rheum. 19 (Suppl.), 16-20.
133. Shinmei, M., Masuda, K., Kikuchi, T., et al. (1991). Production of cytokines by chondrocytes and its role in proteoglycan degradation, J. Rheumatol. 27 (Suppl.), 89-91.
134. Shlopov, B. V., Smith, G. N., Jr., Cole, A. A., et al. (1999). Differential response patterns to doxycycline and TGF-β1 in down-regulation of collagenase in osteoarthritic and normal human chondrocytes, Arthritis Rheum. 42, 719-727.
135. Siegle, I., Klein, T., Backman, J. T., et al. (1998). Expression of cyclooxygenase-1 and cyclooxygenase-2 in human synovial tissue. Differential evaluation of cyclooxygenase-2 in inflammatory joint diseases, Arthritis Rheum. 41(1), 122-129.
136. Sipe, J. D. (1995). Acute phase proteins in osteoarthritis, Semin. Arthritis Rheum. 25, 75-86.
137. Sokoloff, L. (1987). Aging and degenerative diseases affecting cartilage, in: Cartilage, Vol. 3, B. K. Hall (Ed.), pp. 110-114. Academic Press, New York.
138. Soren, A., Klein, W. and Huth, F. (1978). The synovial changes in post-traumatic synovitis and osteoarthritis, Rheumatol. Rehab. 17, 38-45.
139. Spector, T. D., Hart, D. J., Nandra, D., et al. (1997). Low-level increases in serum c-reactive protein are present in early osteoarthritis of the knee and predict progressive disease, Arthritis Rheum. 40, 723-727.
140. Stack, M. T. and Brandt, K. D. (1982). Identification and characterization of articular cartilage hyaluronidase (Haase) [Abstract], Arthritis Rheum. 25 (Suppl.), 100.
141. Stamenkovic, I., Stegagno, M., Wright, K. A., et al. (1988). Clonal dominance among T-lymphocyte infiltrates in arthritis, Proc. Natl. Acad. Sci. USA 85, 1179- 1183.
142. Stefanovic-Racic, M., Stadler, J., Georgescu, H. I., et al. (1994). Nitric oxide and energy production in articular chondrocytes, J. Cell Physiol. 159, 274-280.
143. Stephens, R. W., Ghosh, P, and Taylor, T. K. (1979). Pathogenesis of osteoarthritis, Med. Hypotheses 5, 809-816.
144. Taskiran, D., Stefanovic-Racic, M., Georgescu, H., et al. (1994). Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1, Biochem. Biophys. Res. Commun. 200, 142-148.
145. Vaishnaw, A. J., McNealy, J. D. and Elton, K. A. (1997). Apoptosis in the rheumatic diseases, Arthritis Rheum. 40, 1917-1927.
146. van der Korst, J. K., Sokoloff, L. and Miller, E. R. (1968). Senescent pigmentation of cartilage and degenerative joint disease, Arch. Pathol. 86, 40-60.
147. Vannier, E., Miller, L. C. and Dinarello, C. A. (1992). Coordinated antiinflammatory effects of interleukin 4: Interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist, Proc. Natl. Acad. Sci. USA 89, 4076-4080.
148. Vetto, A. A., Mannik, M., Zatarain-Rios, E., et al. (1990). Immune deposits in articular cartilage of patients with rheumatoid arthritis have a granular pattern not seen in osteoarthritis, Rheumatol. Int. 10, 13-20.
149. 2 activity in human osteoarthritic cartilage, J. Rheumatol. 16, 35-38.
150. Westcott, C. I., Atkins, R. M., Dieppe, P. A., et al. (1994). Tumour necrosis factor-alpha receptor expression on chondrocytes isolated from human articular cartilage, J. Rheumatol. 21, 1710-1715.
151. Woessner, J. F. Jr. (1991). Matrix metalloproteinases and their inhibitors in connective tissue remodeling, FASEB J. 5, 2145-2154.
152. Woessner, J. F., Jr. and Howell, D. S. (1983). Hydrolysis enzymes in cartilage, in: Studies in Joint Disease, Vol. 2, A. Maroudas and E. R. Holborrow (Eds). Pitman Medical Books, Tunbridge Wells, England.
153. Wood, D. J., Awbrey, B. J., Mankin, H. J., et al. (1990). Synthesis of alpha-1-antitrypsin by human articular chondrocytes, Trans. Orthop. Res. Soc. 15, 814-815.