Direct injection of naked DNA and cytokine transgene expression: Implications for keratinocyte gene therapy

Clinical and Experimental Dermatology

Volumn 27, Issue 6, 2002, Pages 480-484

  Sawamura, D ^a   Akiyama, M ^a   Shimizu, H ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; NAKED DNA; PROTEIN LACZ PLASMID; UNCLASSIFIED DRUG;

CIRCULATION; CYTOKINE RELEASE; DIFFUSION; DISEASE SEVERITY; DOWNSTREAM PROCESSING; EPIDERMIS; EPIDERMIS CELL; GENE EXPRESSION; GENE THERAPY; HUMAN; INTRADERMAL DRUG ADMINISTRATION; KERATINOCYTE; NONHUMAN; ORGAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIDE EFFECT; SKIN DISEASE; SKIN INFLAMMATION; SKIN TRANSPLANTATION; TRANSGENE;

BIOLISTICS; CYTOKINES; GENE THERAPY; HUMANS; KERATINOCYTES; SKIN DISEASES; TRANSGENES;

EID: 0036413572     PISSN: 03076938     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2230.2002.01101.x     Document Type: Review

References (27)

1. Vogel JC. Keratinocyte gene therapy. Arch Dermatol 1993; 129: 1478-83.
2. Greenhalgh DA, Rothnagel JA, Roop DR. Epidermis: An attractive target tissue for gene therapy. J Invest Dermatol 1994; 103: 63S-69S.
3. Khavari PA. Genetic correction of inherited epidermal disorders. Hum Gene Ther 2000; 11: 2277-82.
4. Robson MC, Phillips LG, Lawrence WT et al. The safety and effect of topically applied recombinant basic fibroblast growth factor on the healing of chronic pressure sores. Ann Surg 1992; 216: 401-6.
5. Nathan PD, Eisen TG. The biological treatment of renal-cell carcinoma and melanoma. Lancet Oncol 2002; 3: 89-96.
6. Meng X, Sawamura D, Tamai K et al. Keratinocyte gene therapy for systemic diseases: Circulating interleukin-10 released from gene-transferred keratinocytes inhibited contact hypersensitivity at distant areas of the skin. J Clin Invest 1998; 101: 1462-7.
7. Ghazizadeh S, Taichman LB. Virus-mediated gene transfer for cutaneous gene therapy. Hum Gene Ther 2000; 11: 2247-51.
8. Vogel JC. Nonviral skin gene therapy. Hum Gene Ther 2000; 11: 2253-60.
9. Hengge UR, Chan EF, Foster RA, Walker PS, Vogel JC. Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nature Genet 1995; 10: 161-6.
10. Sawamura D, Meng X, Ina S et al. In vivo transfer of a foreign gene to keratinocytes using the hemagglutinating virus of Japan-liposome method. J Invest Dermatol 1997; 108: 195-9.
11. Ina S, Sawamura D, Meng X et al. In vivo gene transfer method in keratinocyte gene therapy: Intradermal injection of DNA complexed with high mobility group-1 protein in rats. Acta Derm Venereol 2000; 80: 10-3.
12. Sawamura D, Meng X, Ina S et al. Expression vector with DNA of bovine papilloma virus 1 for keratinocyte gene therapy. J Dermatol Sci 2000; 23: 111-6.
13. Sawamura D, Meng X, Ina S et al. Promoter/enhancer cassettes for keratinocyte gene therapy. J Invest Dermatol 1999; 112: 829-30.
14. Itai K, Sawamura D, Meng X et al. Keratinocyte gene therapy: Inducible promoters and in vivo control of trans-gene expression. Clin Exp Dermatol 2001; 26: 531-5.
15. Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 1993; 54: 1-78.
16. Sawamura D, Meng X, Ina S et al. Induction of keratinocyte proliferation and lymphocyte infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes. J Immunol 1998; 161: 5633-9.
17. Meng X, Sawamura D, Baba T et al. Transgenic TNF-α causes apoptosis in epidermal keratinocytes after subcutaneous injection of TNF-α DNA plasmid. J Invest Dermatol 1999; 113: 856-7.
18. Sawamura D, Yasukawa K, Kodama K et al. The majority of keratinocytes incorporate intradermally injected plasmid DNA regardless of size but only a small proportion of cells can express the gene product. J Invest Dermatol 2002; 118: 967-71.
19. Schwarz A, Grabbe S, Riemann H et al. In vivo effects of interleukin-10 on contact hypersensitivity and delayed-type hypersensitivity reactions. J Invest Dermatol 1994; 103: 211-6.
20. Meng X, Sawamura D, Ina S et al. Keratinocyte gene therapy: Cytokine gene expression in local keratinocytes and in circulation by introducing cytokine genes into skin. Exp Dermatol, in press.
21. Hengge UR, Walker PS, Vogel JC. Expression of naked DNA in human, pig, and mouse skin. J Clin Invest 1996; 97: 2911-6.
22. Sawamura D, Ina S, Itai K et al. In vivo gene introduction into keratinocytes using jet injection. Gene Ther 1999; 6: 1785-7.
23. Sato M, Sawamura D, Ina S et al. In vivo introduction of the IL-6 gene into human keratinocytes: Induction of epidermal proliferation by the fully spliced form of IL-6 but not by the alternatively spliced form. Arch Dermatol Res 1999; 291: 400-4.
24. Baek SC, Lin Q, Robbins PB, Fan H, Khavari PA. Sustainable systemic delivery via a single injection of lentivirus into human skin tissue. Hum Gene Ther 2001; 12: 1551-8.
25. Kuhn U, Terunuma A, Pfutzner W et al. In vivo assessment of gene delivery to keratinocytes by lentiviral vectors. J Virol 2002; 76: 1496-504.
26. Gilkeson GS, Pippen AM, Pisetsky DS. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J Clin Invest 1995; 95: 1398-402.
27. Baumqartner I, Pieczek A, Manor O et al. Constitutive expression of phVEGF 15 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 1998; 97: 1114-23.