Sustainable systemic delivery via a single injection of lentivirus into human skin tissue

Human Gene Therapy

Volumn 12, Issue 12, 2001, Pages 1551-1558

  Baek, Seung Cheol ^a,b   Lin, Qun ^a   Robbins, Paul B ^a   Fan, Hongran ^a   Khavari, Paul A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; LENTIVIRUS VECTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CELL TYPE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ENDOTHELIUM CELL; EXCISION; GENE EXPRESSION; GENE TRANSFER; HEMATOCRIT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; IMMUNE DEFICIENCY; INJECTION SITE; KERATINOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; SKIN FIBROBLAST; SKIN GRAFT; SKIN TRANSPLANTATION; TARGET CELL;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM; ERYTHROPOIETIN; FIBROBLASTS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMATOCRIT; HUMANS; KERATINOCYTES; LENTIVIRUS; MACROPHAGES; MICE; MICE, SCID; PEPTIDES; SKIN; TIME FACTORS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; MURINE LEUKEMIA VIRUS;

EID: 0035572944     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340152480276     Document Type: Article

References (55)

1. Ligand-dependent regulation of vascular endothelial growth factor and erythropoietin expression by a plasmid-based autoinducible GeneSwitch system
2. Na(+)-dependent high affinity uptake of L-glutamate in primary cultures of human fibroblasts isolated from three different types of tissue
3. Transfer of the feline erythropoietin gene to cats using a recombinant adeno-associated virus vector
4. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts
5. Regulated cutaneous gene delivery: The skin as a bioreactor
6. Direct cutaneous gene delivery in a human genetic skin disease
7. Transglutaminase 1 delivery to lamellar ichthyosis keratinocytes
8. Corrective gene transfer in the human skin disorder lamellar ichthyosis
9. Improvement of mouse beta-thalassemia upon erythropoietin delivery by encapsulated myoblasts
10. Particle-mediated gene therapy of wounds
11. Toward epidermal stem cell-mediated ex vivo gene therapy of junctional epidermolysis bullosa
12. Sustainable cutaneous gene delivery
13. High efficiency gene transfer and pharmacologic selection of genetically engineered human keratinocytes
14. VSVG pseudotyped lentiviral vector particles produced in human cells are inactivated by human serum
15. Efficient delivery of transgenes to human hair follicle progenitor cells using topical lipoplex
16. Selective uptake and sustained expression of AAV vectors following subcutaneous delivery
17. A third-generation lentivirus vector with a conditional packaging system
18. Genetic immunization via hair follicles after topical application of naked DNA to normal skin
19. Systemic distribution of apolipoprotein E secreted by grafts of epidermal keratinocytes: Implications for epidermal function and gene therapy
20. A model of corrective gene transfer in X-linked ichthyosis
21. Fas signal transduction triggers either proliferation or apop-tosis in human fibroblasts
22. Towards gene therapy for haemophilia B using primary human keratinocytes
23. Virus-mediated gene transfer for cutaneous gene therapy
24. In vivo transduction of mouse epidermis with recombinant retroviral vectors: Implications for cutaneous gene therapy
25. Myoblast transfer of human erythropoietin gene in a mouse model of renal failure
26. Cytokine gene expression in epidermis with biological effects following injection of naked DNA
27. Expression of naked DNA in human, pig, and mouse skin
28. Gene transfer into cultured human epidermis and its transplantation onto immunodeficient mice: An experimental model for somatic gene therapy
29. A packaging cell line for lentivirus vectors
30. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
31. Genetic correction of inherited epidermal disorders
32. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle
33. Lentivirus vectors for gene therapy
34. The feasibility of targeted selective gene therapy of the hair follicle
35. Topical application of viral vectors for epidermal gene transfer
36. Evaluation of human skin reconstituted from composite grafts of cultured keratinocytes and human acellular dermis transplanted to athymic mice
37. Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin
38. Expression of an exogenous growth hormone gene by transplantable human epidermal cells
39. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
40. Sustained production of human transferrin by transduced fibroblasts implanted into athymic mice: A model for somatic gene therapy
41. In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa
42. Dose response to a single intramuscular injection of recombinant adeno-associated virus-erythropoietin in monkeys
43. BP180 gene delivery in junctional epidermolysis bullosa
44. Control of erythropoietin secretion by doxy-cycline or mifepristone in mice bearing polymer-encapsulated engineered cells
45. Ross River virus glycoprotein-pseudotyped retroviruses and stable cell lines for their production
46. Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1
47. Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector
48. Human growth hormone in the blood of athymic mice grafted with cultures of hormone-secreting human keratinocytes
49. The genodermatoses: Candidate diseases for gene therapy
50. Nonviral skin gene therapy
51. In vivo gene therapy with interleukin-12 inhibits primary vascular tumor growth and induces apoptosis in a mouse model
52. Transgenic studies with a keratin promoter-driven growth hormone transgene: Prospects for gene therapy
53. Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy
54. Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer
55. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery