Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP depletion

Biochemical and Biophysical Research Communications

Volumn 298, Issue 2, 2002, Pages 235-239

  Yoshizawa, Fumiaki ^a   Watanabe, Emi ^a   Sugahara, Kunio ^a   Natori, Yasuo ^b  

^a UTSUNOMIYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY OF ARTS AND SCIENCES   (Japan)

Author keywords

4E BP1; ATP depletion; eIF4E; Ethionine; Liver; Rats; S6K1; Translation initiation

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; BINDING PROTEIN; ETHIONINE; INITIATION FACTOR 4E; METHIONINE; PROTEIN; PROTEIN KINASE; RAPAMYCIN; RIBOSOME PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; EUKARYOTE; LIVER; MAMMAL; MOLECULAR WEIGHT; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM; TRANSLATION INITIATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; ETHIONINE; EUKARYOTIC INITIATION FACTOR-4E; FEMALE; LIVER; PEPTIDE INITIATION FACTORS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, WISTAR; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA;

EUKARYOTA; MAMMALIA;

EID: 0036405107     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02443-9     Document Type: Article

References (29)

1. E. Farber, M.S. Corban, Sex difference in ethionine inhibition of hepatic protein synthesis, J. Biol. Chem. 233 (1958) 625-630.
2. Y. Natori, Studies on ethionine. VI. Sex-dependent behavior of methionine and ethionine in rats, J. Biol. Chem. 238 (1963) 2075-2080.
3. S. Villa-Trevino, K.H. Shull, E. Farber, The role of adenosine triphosphate deficiency in ethionine-induced inhibition of protein synthesis, J. Biol. Chem. 238 (1963) 1757-1763.
4. K.H. Shull, S. Villa-Trevino, The effects of hadacidin and inosine on hepatic protein synthesis and adenosine triphosphate levels in ethionine-treated rats, Biochem. Biophys. Res. Commun. 16 (1964) 101-105.
5. E. Farber, K.H. Shull, J.M. McConomy, A.E. Castillo, The effects of inosine and aminoimidazole carboxamide upon the ethionine fatty liver, Biochem. Pharmacol. 14 (1965) 761-767.
6. Y. Endo, H. Tominaga, Y. Natori, The state of messenger ribonucleic acid and ribosomes in the cytoplasm of ethionine-treated rat liver, Biochim. Biophys. Acta 383 (1975) 305-315.
7. R. Kisilevsky, The regulatory parameter of protein synthesis most affected by ethionine, and cycloheximide. A comparison of computer and in vivo studies, Biochim. Biophys. Acta 272 (1972) 463-472.
8. W.C. Merrick, Eukaryotic protein synthesis: An in vitro analysis, Biochimie. 76 (1994) 822-830.
9. V.M. Pain, Initiation of protein synthesis in eukaryotic cells, Eur. J. Biochem. 236 (1996) 747-771.
10. A. Dufner, G. Thomas, Ribosomal S6 kinase signaling and the control of translation, Exp. Cell. Res. 253 (1999) 100-109.
11. M. Hase, Y. Endo, Y. Natori, The role of translational inhibitor in ethionine-induced inhibition of protein synthesis, Biochim. Biophys. Acta 698 (1982) 102-104.
12. A.W. Lyon, R. Kisilevsky, Inhibition of the initiation of hepatic protein synthesis during ethionine mediated ATP depletion in vivo: modification to ribosomal subunits, evidence of impaired ternary complex formation and a subcellular redistribution of eIF-2α, Biochim. Biophys. Acta 1049 (1990) 158-170.
13. A. Pause, G.J. Belsham, A.C. Gingras, O. Donze, T.A. Lin, J.C. Lawrence Jr., N. Sonenberg, Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function, Nature 371 (1994) 762-767.
14. S.J. Morley, M. Rau, J.E. Kay, V.M. Pain, Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation, Eur. J. Biochem. 218 (1993) 39-48.
15. W.B. Minich, M.L. Balasta, D.J. Goss, R.E. Rhoads, Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: Increased cap affinity of the phosphorylated form, Proc. Natl. Acad. Sci. USA 91 (1994) 7668-7672.
16. B. Cheatham, C.J. Vlahos, L. Cheatham, L. Wang, J. Blenis, C.R. Kahn, Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation, Mol. Cell. Biol. 14 (1994) 4902-4911.
17. J. Chung, T.C. Grammer, K.P. Lemon, A. Kazlauskas, J. Blenis, PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase, Nature 370 (1994) 71-75.
18. F. Yoshizawa, S.R. Kimball, T.C. Vary, L.S. Jefferson, Effect of dietary protein on translation initiation in rat skeletal muscle and liver, Am. J. Physiol. 275 (1998) E814-E820.
19. S.R. Kimball, C.V. Jurasinski, J.C. Lawrence, L.S. Jefferson, Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G, Am. J. Physiol. 272 (1997) C754-C759.
20. E. Svanberg, L.S. Jefferson, K. Lundholm, S.R. Kimball, Post-prandial stimulation of muscle protein synthesis is independent of changes in insulin, Am. J. Physiol. 272 (1997) E841-E847.
21. S.R. Kimball, R.L. Horetsky, L.S. Jefferson, Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts, Am. J. Physiol. 274 (1998) C221-C228.
22. N. Sonenberg, mRNA 5″ cap-binding protein eIF4E and control of cell growth, in: J.W.B. Hershey, M.B. Mathews, N. Sonenberg (Eds.), Translational Control, Cold Spring Harber Laboratory Press, Plainview, New York, 1996, pp. 245-269.
23. Q.P. Weng, M. Kozlowski, C. Belham, A. Zhang, M.J. Comb, J. Avruch, Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies, J. Biol. Chem. 273 (1998) 16621-16629.
24. G.J. Brunn, C.C. Hudson, A. Sekulic, J.M. Williams, H. Hosoi, P.J. Houghton, J.C. Lawrence Jr., R.T. Abraham, Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin, Science 277 (1997) 99-101.
25. K. Hara, K. Yonezawa, M.T. Kozlowski, T. Sugimoto, K. Andrabi, Q.P. Weng, M. Kasuga, I. Nishimoto, J. Avruch, Regulation of eIF-4E BP1 phosphorylation by mTOR, J. Biol. Chem. 272 (1997) 26457-26463.
26. P.E. Burnett, R.K. Barrow, N.A. Cohen, S.H. Snyder, D.M. Sabatini, RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1, Proc. Natl. Acad. Sci. USA 95 (1998) 1432-1437.
27. P.B. Dennis, A. Jaeschke, M. Saitoh, B. Fowler, S.C. Kozma, G. Thomas, Mammalian TOR: A homeostatic ATP sensor, Science 294 (2001) 1102-1105.
28. J.C. Anthony, F. Yoshizawa, T.G. Anthony, T.C. Vary, L.S. Jefferson, S.R. Kimball, Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway, J. Nutr. 130 (2000) 2413-2419.
29. N.T. Redpath, C.G. Proud, Molecular mechanisms in the control of translation by hormones and growth factors, Biochim. Biophys. Acta 1220 (1994) 147-162.