The O-GlcNAcase theory of diabetes: Commentary on a candidate gene for diabetes

Molecular Genetics and Metabolism

Volumn 77, Issue 1-2, 2002, Pages 1-2

  Kudlow, Jeffrey E ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; STREPTOZOCIN; TRANSFERASE; ACETYLGLUCOSAMINIDASE; BETA N ACETYLHEXOSAMINIDASE; GLUCOSE; HISTONE ACETYLTRANSFERASE; MULTIENZYME COMPLEX; PEPTIDE O LINKED N ACETYLGLUCOSAMINE BETA N ACETYLGLUCOSAMINIDASE; PEPTIDE O-LINKED N-ACETYLGLUCOSAMINE-BETA-N-ACETYLGLUCOSAMINIDASE;

CHROMOSOME 1; CHROMOSOME 10; DIABETES MELLITUS; DRUG SPECIFICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE LOCUS; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SEASONAL VARIATION; SHORT SURVEY; AMERICAN INDIAN; BIOLOGICAL MODEL; ENZYMOLOGY; GENETICS; METABOLISM; NOTE; PANCREAS ISLET;

ACETYLGLUCOSAMINIDASE; BETA-N-ACETYLHEXOSAMINIDASE; CHROMOSOMES, HUMAN, PAIR 10; DIABETES MELLITUS, TYPE 2; GLUCOSE; HISTONE ACETYLTRANSFERASES; HUMANS; INDIANS, NORTH AMERICAN; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES;

EID: 0036395058     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-7192(02)00128-2     Document Type: Article

References (11)

1. V.S. Farook, C. Bogardas, M. Prochazka, Analysis of MGEA5 on 10g24.1-g24.3 encoding the β-O-linked N-acetylglucosaminidase (O-GlcNAcase) as a candidate gene for type 2 diabetes mellitus in Pima Indians, Mol. Genet. Metabol. (2002).
2. R. Duggirala, J. Blangero, L. Almasy, D.T. Dyer, K.L. Williams, R.J. Leach, P. O'Connell, M.P. Stern, Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican-Americans, Am. J. Hum. Genet. 64 (1999) 1127-1140.
3. H. Fakhrai-Rad, A. Nikoshkov, A. Kamel, M. Fernstrom, J.R. Zierath, S. Norgren, H. Luthman, J. Galli, Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats, Hum. Mol. Genet. 14 (2000) 2149-2158.
4. K. Liu, A.J. Paterson, E. Chin, J.E. Kudlow, Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death, Proc. Natl. Acad. Sci. USA 97 (2000) 2820-2825.
5. K. Liu, A.J. Paterson, R.J. Konrad, A.F. Parlow, S. Jimi, M. Roh, E. Chin, J.E. Kudlow, Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion, Mol. Cell. Endocrinol. (2002) in press.
6. K. Vosseller, L. Wells, M.D. Lane, G.W. Hart, Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes, Proc. Natl. Acad. Sci. USA 99 (2002) 5313-5318.
7. R.J. Konrad, I. Mikolaenko, J.F. Tolar, K. Liu, J.E. Kudlow, The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc selective N-acetyl-beta-D-glucosaminidase, Biochem. J. 356 (2001) 31-41.
8. X. Yang, K. Su, M.D. Roos, A.J. Paterson, J.E. Kudlow, O-Linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability, Proc. Natl. Acad. Sci. USA 98 (2001) 6611-6616.
9. X. Yang, F. Zhang, J.E. Kudlow, Recruitment of O-GlcNAc Transferase to Promoters by Corepressor mSin3A: Coupling Protein O-GlcNAcylation to Transcriptional Repression, Cell 110 (2002) 69-80.
10. K. Su, M.D. Roos, X. Yang, I.-O. Han, A.J. Paterson, J.E. Kudlow, An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitro, J. Biol. Chem. 274 (1999) 15194-15202.
11. R. Sha., S.P. Iyer, L.G. Ellies, N. O'Donnell, K.W. Marek, D. Chui, G.W. Hart, J.D. Marth, The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny, Proc. Natl. Acad. Sci. USA 97 (2000) 5735-5739.