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Volumn 297, Issue 3, 2002, Pages 607-615

The homeobox gene Cdx1 belongs to the p53-p21WAF-Bcl-2 network in intestinal epithelial cells

Author keywords

Bcl 2; Cdx1; Colorectal cancer; Intestinal cells; p21; p53

Indexed keywords

DOXORUBICIN; MUTANT PROTEIN; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX1; UNCLASSIFIED DRUG;

EID: 0036389805     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02250-7     Document Type: Article
Times cited : (25)

References (48)
  • 1
    • 0024260180 scopus 로고
    • A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine
    • P. Duprey, K. Chowdhury, G.R. Dressler, R. Balling, D. Simon, J.L. Guenet, P. Gruss, A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine, Genes Dev. 2 (1988) 1647-1654.
    • (1988) Genes Dev. , vol.2 , pp. 1647-1654
    • Duprey, P.1    Chowdhury, K.2    Dressler, G.R.3    Balling, R.4    Simon, D.5    Guenet, J.L.6    Gruss, P.7
  • 2
    • 0025906410 scopus 로고
    • Homeobox gene expression in the intestinal epithelium of adult mice
    • R. James, J. Kazenwadel, Homeobox gene expression in the intestinal epithelium of adult mice, J. Biol. Chem. 266 (1991) 3246-3251.
    • (1991) J. Biol. Chem. , vol.266 , pp. 3246-3251
    • James, R.1    Kazenwadel, J.2
  • 3
    • 0027498893 scopus 로고
    • Mouse Cdx-1 expression during gastrulation
    • B.I. Meyer, P. Gruss, Mouse Cdx-1 expression during gastrulation, Development 117 (1993) 191-203.
    • (1993) Development , vol.117 , pp. 191-203
    • Meyer, B.I.1    Gruss, P.2
  • 4
    • 0028800024 scopus 로고
    • Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes
    • V. Subramanian, B.I. Meyer, P. Gruss, Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes, Cell 83 (1995) 641-653.
    • (1995) Cell , vol.83 , pp. 641-653
    • Subramanian, V.1    Meyer, B.I.2    Gruss, P.3
  • 5
    • 0026491116 scopus 로고
    • Gradient expression of Cdx along the rat intestine throughout postnatal development
    • J.N. Freund, R. Boukamel, A. Benazzouz, Gradient expression of Cdx along the rat intestine throughout postnatal development, FEBS Lett. 314 (1992) 163-166.
    • (1992) FEBS Lett. , vol.314 , pp. 163-166
    • Freund, J.N.1    Boukamel, R.2    Benazzouz, A.3
  • 6
    • 0030911194 scopus 로고    scopus 로고
    • Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells
    • I. Duluc, O. Lorentz, C. Fritsch, C. Leberquier, M. Kedinger, J.N. Freund, Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells, J. Cell Sci. 110 (1997) 1317-1324.
    • (1997) J. Cell Sci. , vol.110 , pp. 1317-1324
    • Duluc, I.1    Lorentz, O.2    Fritsch, C.3    Leberquier, C.4    Kedinger, M.5    Freund, J.N.6
  • 7
    • 0030795415 scopus 로고    scopus 로고
    • CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium
    • D.G. Silberg, E.E. Furth, J.K. Taylor, T. Schuck, T. Chiou, P.G. Traber, CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium, Gastroenterology 113 (1997) 478-486.
    • (1997) Gastroenterology , vol.113 , pp. 478-486
    • Silberg, D.G.1    Furth, E.E.2    Taylor, J.K.3    Schuck, T.4    Chiou, T.5    Traber, P.G.6
  • 9
    • 0031742867 scopus 로고    scopus 로고
    • The murine Cdx1 gene product localises to the proliferative compartment in the developing and regenerating intestinal epithelium
    • V. Subramanian, B. Meyer, G.S. Evans, The murine Cdx1 gene product localises to the proliferative compartment in the developing and regenerating intestinal epithelium, Differentiation 64 (1998) 11-18.
    • (1998) Differentiation , vol.64 , pp. 11-18
    • Subramanian, V.1    Meyer, B.2    Evans, G.S.3
  • 11
    • 0031440118 scopus 로고    scopus 로고
    • Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
    • O. Lorentz, I. Duluc, A.D. Arcangelis, P. Simon-Assmann, M. Kedinger, J.N. Freund, Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation, Cell. Biol. 139 (1997) 1553-1565.
    • (1997) Cell. Biol. , vol.139 , pp. 1553-1565
    • Lorentz, O.1    Duluc, I.2    Arcangelis, A.D.3    Simon-Assmann, P.4    Kedinger, M.5    Freund, J.N.6
  • 12
    • 0027602870 scopus 로고
    • The oncogenic potential of deregulated homeobox genes
    • C.C. Maulbecker, P. Gruss, The oncogenic potential of deregulated homeobox genes, Cell Growth Differ. 4 (1993) 431-441.
    • (1993) Cell Growth Differ. , vol.4 , pp. 431-441
    • Maulbecker, C.C.1    Gruss, P.2
  • 13
    • 0035849796 scopus 로고    scopus 로고
    • Homeobox gene Cdx-1 regulates Ras, Rho, and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells
    • P. Soubeyran, K. Haglund, S. Garcia, B.U. Barth, J.L. Iovanna, I. Dikic, Homeobox gene Cdx-1 regulates Ras, Rho, and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells, Oncogene 20 (2001) 4180-4187.
    • (2001) Oncogene , vol.20 , pp. 4180-4187
    • Soubeyran, P.1    Haglund, K.2    Garcia, S.3    Barth, B.U.4    Iovanna, J.L.5    Dikic, I.6
  • 14
    • 0033894544 scopus 로고    scopus 로고
    • Expression of an intestine-specific transcription factor (CDX1) in intestinal metaplasia and in subsequently developed intestinal type of cholangiocarcinoma in rat liver
    • P. Ren, D.G. Silberg, A.E. Sirica, Expression of an intestine-specific transcription factor (CDX1) in intestinal metaplasia and in subsequently developed intestinal type of cholangiocarcinoma in rat liver, Am. J. Pathol. 156 (2000) 621-627.
    • (2000) Am. J. Pathol. , vol.156 , pp. 621-627
    • Ren, P.1    Silberg, D.G.2    Sirica, A.E.3
  • 20
    • 0032578019 scopus 로고    scopus 로고
    • Stem cells in gastrointestinal epithelium: Numbers, characteristics and death
    • C.S. Potten, Stem cells in gastrointestinal epithelium: numbers, characteristics and death, Philos. Trans. R. Soc. London B. Biol. Sci. 353 (1998) 821-830.
    • (1998) Philos. Trans. R. Soc. London B. Biol. Sci. , vol.353 , pp. 821-830
    • Potten, C.S.1
  • 21
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • A.J. Merritt, C.S. Potten, C.J. Kemp, J.A. Hickman, A. Balmain, D.P. Lane, P.A. Hall, The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice, Cancer Res. 54 (1994) 614-617.
    • (1994) Cancer Res. , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 24
    • 0029048596 scopus 로고
    • Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia
    • A.J. Merritt, C.S. Potten, A.J. Watson, D.Y. Loh, K. Nakayama, J.A. Hickman, Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia, J. Cell Sci. 108 (1995) 2261-2271.
    • (1995) J. Cell Sci. , vol.108 , pp. 2261-2271
    • Merritt, A.J.1    Potten, C.S.2    Watson, A.J.3    Loh, D.Y.4    Nakayama, K.5    Hickman, J.A.6
  • 25
    • 0029914705 scopus 로고    scopus 로고
    • Cell cycle protein suppression and p21 induction in differentiating Caco-2 cells
    • B.M. Evers, T.C. Ko, J. Li, E.A. Thompson, Cell cycle protein suppression and p21 induction in differentiating Caco-2 cells, Am. J. Physiol. 271 (1996) G722-G727.
    • (1996) Am. J. Physiol. , vol.271
    • Evers, B.M.1    Ko, T.C.2    Li, J.3    Thompson, E.A.4
  • 26
    • 0033027864 scopus 로고    scopus 로고
    • Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation
    • J.Q. Tian, A. Quaroni, Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation, Am. J. Physiol. 276 (1999) C1245-C1258.
    • (1999) Am. J. Physiol. , vol.276
    • Tian, J.Q.1    Quaroni, A.2
  • 27
    • 0029791681 scopus 로고    scopus 로고
    • p21/WAF1/CIP1 expression in normal mucosa and in adenomas and adenocarcinomas of the colon: Its relationship with differentiation
    • C. Doglioni, P. Pelosio, L. Laurino, E. Macri, E. Meggiolaro, F. Favretti, M. Barbareschi, p21/WAF1/CIP1 expression in normal mucosa and in adenomas and adenocarcinomas of the colon: its relationship with differentiation, J. Pathol. 179 (1996) 248-253.
    • (1996) J. Pathol. , vol.179 , pp. 248-253
    • Doglioni, C.1    Pelosio, P.2    Laurino, L.3    Macri, E.4    Meggiolaro, E.5    Favretti, F.6    Barbareschi, M.7
  • 30
    • 0023779204 scopus 로고
    • Alternative promoters and exons, somatic mutation, and deregulation of the Bcl2-Ig fusion gene in lymphoma
    • M. Seto, U. Jeager, R.D. Hockett, W. Graninger, S. Bennett, P. Goldman, S.J. Korsmeyer, Alternative promoters and exons, somatic mutation, and deregulation of the Bcl2-Ig fusion gene in lymphoma, EMBO J. 7 (1988) 123-131.
    • (1988) EMBO J. , vol.7 , pp. 123-131
    • Seto, M.1    Jeager, U.2    Hockett, R.D.3    Graninger, W.4    Bennett, S.5    Goldman, P.6    Korsmeyer, S.J.7
  • 31
    • 0031058741 scopus 로고    scopus 로고
    • The pancreatitis-associated protein I promoter allows targeting to the pancreas of a foreign gene, whose expression is up-regulated during pancreatic inflammation
    • N.J. Dusetti, S. Vasseur, E.M. Ortiz, H. Romeo, J.C. Dagorn, O. Burrone, J.L. Iovanna, The pancreatitis-associated protein I promoter allows targeting to the pancreas of a foreign gene, whose expression is up-regulated during pancreatic inflammation, J. Biol. Chem. 272 (1997) 5800-5804.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5800-5804
    • Dusetti, N.J.1    Vasseur, S.2    Ortiz, E.M.3    Romeo, H.4    Dagorn, J.C.5    Burrone, O.6    Iovanna, J.L.7
  • 32
    • 0035115608 scopus 로고    scopus 로고
    • Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I
    • V. Moucadel, P. Soubeyran, S. Vasseur, N.J. Dusetti, J.C. Dagorn, J.L. Iovanna, Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I, Eur. J. Cell Biol. 80 (2001) 156-163.
    • (2001) Eur. J. Cell Biol. , vol.80 , pp. 156-163
    • Moucadel, V.1    Soubeyran, P.2    Vasseur, S.3    Dusetti, N.J.4    Dagorn, J.C.5    Iovanna, J.L.6
  • 33
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • M.M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 34
    • 0029670539 scopus 로고    scopus 로고
    • cis-acting elements and transcription factors involved in the intestinal specific expression of the rat calbindin-D9K gene: Binding of the intestine-specific transcription factor Cdx-2 to the TATA box
    • M. Lambert, S. Colnot, E. Suh, F. L3Horset, C. Blin, M.E. Calliot, M. Raymondjean, M. Thomasset, P.G. Traber, C. Perret, cis-Acting elements and transcription factors involved in the intestinal specific expression of the rat calbindin-D9K gene: binding of the intestine-specific transcription factor Cdx-2 to the TATA box, Eur. J. Biochem. 236 (1996) 778-788.
    • (1996) Eur. J. Biochem. , vol.236 , pp. 778-788
    • Lambert, M.1    Colnot, S.2    Suh, E.3    L'Horset, F.4    Blin, C.5    Calliot, M.E.6    Raymondjean, M.7    Thomasset, M.8    Traber, P.G.9    Perret, C.10
  • 35
    • 0033607763 scopus 로고    scopus 로고
    • Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3
    • F. Xu, H. Li, T. Jin, Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3, J. Biol. Chem. 274 (1999) 34310-34316.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34310-34316
    • Xu, F.1    Li, H.2    Jin, T.3
  • 36
    • 0034056039 scopus 로고    scopus 로고
    • A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells
    • C.A. Heckman, J.W. Mehew, G.G. Ying, M. Introna, J. Golay, L.M. Boxer, A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells, J. Biol. Chem. 275 (2000) 6499-6508.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6499-6508
    • Heckman, C.A.1    Mehew, J.W.2    Ying, G.G.3    Introna, M.4    Golay, J.5    Boxer, L.M.6
  • 37
    • 0028243649 scopus 로고
    • Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium
    • R. James, T. Erler, J. Kazenwadel, Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium, J. Biol. Chem. 269 (1994) 15229-15237.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15229-15237
    • James, R.1    Erler, T.2    Kazenwadel, J.3
  • 38
    • 0030032310 scopus 로고    scopus 로고
    • An intestine-specific homeobox gene regulates proliferation and differentiation
    • E. Suh, P.G. Traber, An intestine-specific homeobox gene regulates proliferation and differentiation, Mol. Cell. Biol. 16 (1996) 619-625.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 619-625
    • Suh, E.1    Traber, P.G.2
  • 39
    • 0028080881 scopus 로고
    • A homeodomain protein related to caudal regulates intestine-specific gene transcription
    • E. Suh, L. Chen, J. Taylor, P.G. Traber, A homeodomain protein related to caudal regulates intestine-specific gene transcription, Mol. Cell. Biol. 14 (1994) 7340-7351.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7340-7351
    • Suh, E.1    Chen, L.2    Taylor, J.3    Traber, P.G.4
  • 40
    • 0030973758 scopus 로고    scopus 로고
    • Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2
    • J.T. Troelsen, C. Mitchelmore, N. Spodsberg, A.M. Jensen, O. Noren, H. Sjostrom, Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2, Biochem. J. 322 (1997) 833-838.
    • (1997) Biochem. J. , vol.322 , pp. 833-838
    • Troelsen, J.T.1    Mitchelmore, C.2    Spodsberg, N.3    Jensen, A.M.4    Noren, O.5    Sjostrom, H.6
  • 41
    • 0033610786 scopus 로고    scopus 로고
    • Intestinal expression of the calbindin-D9K gene in transgenic mice. Requirement for a Cdx2-binding site in a distal activator region
    • S. Colnot, B. Romagnolo, M. Lambert, F. Cluzeaud, A. Porteu, A. Vandewalle, M. Thomasset, A. Kahn, C. Perret, Intestinal expression of the calbindin-D9K gene in transgenic mice. Requirement for a Cdx2-binding site in a distal activator region, J. Biol. Chem. 273 (1998) 31939-31946.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31939-31946
    • Colnot, S.1    Romagnolo, B.2    Lambert, M.3    Cluzeaud, F.4    Porteu, A.5    Vandewalle, A.6    Thomasset, M.7    Kahn, A.8    Perret, C.9
  • 42
    • 0032548782 scopus 로고    scopus 로고
    • Colon carbonic anhydrase 1: Transactivation of gene expression by the homeodomain protein Cdx2
    • F.J. Drummond, J. Sowden, K. Morrison, Y.H. Edwards, Colon carbonic anhydrase 1: transactivation of gene expression by the homeodomain protein Cdx2, FEBS Lett. 423 (1998) 218-222.
    • (1998) FEBS Lett. , vol.423 , pp. 218-222
    • Drummond, F.J.1    Sowden, J.2    Morrison, K.3    Edwards, Y.H.4
  • 43
    • 0034234529 scopus 로고    scopus 로고
    • Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx2
    • J. Park, S. Schulz, S.A Waldman, Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx2, Gastroenterology 119 (2000) 89-96.
    • (2000) Gastroenterology , vol.119 , pp. 89-96
    • Park, J.1    Schulz, S.2    Waldman, S.A.3
  • 44
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • X. Wu, J.H. Bayle, D. Olson, A.J. Levine, The p53-mdm-2 autoregulatory feedback loop, Genes Dev. 7 (1993) 1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 45
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • Y. Barak, T. Juven, R. Haffner, M. Oren, mdm2 expression is induced by wild type p53 activity, EMBO J. 12 (1993) 461-468.
    • (1993) EMBO J. , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 48
    • 0029909531 scopus 로고    scopus 로고
    • Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein
    • G. Farmer, P. Friedlander, J. Colgan, J.L. Manley, C. Prives, Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein, Nucleic Acids Res. 24 (1996) 4281-4288.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4281-4288
    • Farmer, G.1    Friedlander, P.2    Colgan, J.3    Manley, J.L.4    Prives, C.5


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