Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: The importance of fetal or post partum exposure to diabetogenic molecules

Diabetologia

Volumn 45, Issue 9, 2002, Pages 1340-1343

  Pani, M ^a   Van Autreve, J ^b   Van Der Auwera, B ^b   Gorus, F ^b   Badenhoop, K ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b DIABETES RESEARCH CENTER   (Belgium)

Author keywords

Beta cell autoimmunity; Genetic susceptibility; HLA; Maternal transmission; Microchimerism

Indexed keywords

OLIGONUCLEOTIDE;

ALLELE; ARTICLE; CHI SQUARE TEST; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HETEROZYGOSITY; HUMAN; HYBRIDIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROGENY; PUERPERIUM; RHEUMATOID ARTHRITIS; RISK FACTOR; UTERUS;

ALLELES; DIABETES MELLITUS, TYPE 1; FATHERS; FEMALE; GENOMIC IMPRINTING; HLA-DQ ANTIGENS; HUMANS; MALE; MOTHERS; NUCLEAR FAMILY; PEDIGREE; SEX CHARACTERISTICS;

EID: 0036381991     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0900-z     Document Type: Article

References (18)

1. Nerup J, Platz P, Andersen OO (1974) HLA antigens and diabetes mellitus. Lancet ii: 864-866
2. Lie BA, Todd JA, Pociot F et al. (1999) The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene. Am J Hum Genet 64: 793-800
3. Otonkoski T, Roivainen M, Vaarala O et al. (2000) Neonatal Type I diabetes associated with maternal echovirus 6 infection: a case report. Diabetologia 43: 1235-1238
4. Undlien DE, Lie BA, Thorsby E (2001) HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved? Trends Genet 17: 93-100
5. Cucca F, Lampis R, Congia M et al. (2001) A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. Hum Mol Genet 10: 2025-2037
6. Badenhoop K, Walfish PG, Rau H et al. (1995) Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune diseases. J Clin Endocrinol Metab 80: 2112-2117
7. Heimberg H, Nagy ZP, Somers G, De Leeuw, Schuit FC (1992) Complementation of HLA-DQA and -DQB genes confers susceptibility and protection to insulin-dependent diabetes mellitus. Hum Immunol 33: 10-17
8. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52: 506-516
9. Kockum I, Wassmuth R, Holmberg E, Michelsen B, Lernmark A (1994) Inheritance of MHC class II genes in IDDM studied in population-based affected and control families. Diabetologia 37: 1105-1112
10. Wolde S ten, Breedveld FC, Vries RR de et al. (1993) Influence of non-inherited maternal HLA antigens on occurrence of rheumatoid arthritis. Lancet 341: 200-202
11. Rood JJ van, Claas F (2000) Noninherited maternal HLA antigens: a proposal to elucidate their role in the immune response. Hum Immunol 61: 1390-1394
12. Evans PC, Lambert N, Maloney S, Furst DE, Moore JM, Nelson JL (1999) Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood 93: 2033-2037
13. Maloney S, Smith A, Furst DE et al. (1999) Microchimerism of maternal origin persists into adult life. J Clin Invest 104: 41-47
14. Reed AM, Picornell YJ, Harwood A, Kredich DW (2000) Chimerism in children with juvenile dermatomyositis. Lancet 356: 2156-2157
15. Artlett CM, Miller FW, Rider LG (2001) Persistent maternally derived peripheral microchimerism is associated with the juvenile idiopathic inflammatory myopathies. Rheumatology (Oxford) 40: 1279-1284
16. Ando T, Imaizumi M, Graves PN, Unger P, Davies TF (2002) Intrathyroidal fetal microchimerism in Graves' disease. J Clin Endocrinol Metab (in press)
17. Srivatsa B, Srivatsa S, Johnson KL, Samura O, Lee SL, Bianchi DW (2001) Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study. Lancet 358: 2034-2038
18. Lee KH, Wucherpfennig KW, Wiley DC (2001) Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol 2: 501-507