The product of the UL12.5 gene of herpes simplex virus type 1 is not essential for lytic viral growth and is not specifically associated with capsids

Virology

Volumn 298, Issue 2, 2002, Pages 248-257

  Martinez, Rik ^a   Goldstein, Joshua N ^a   Weller, Sandra K ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MUTANT PROTEIN; NUCLEASE; PROTEIN UL 12 5; SUCROSE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE MAPPING; GENE MUTATION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; NONHUMAN; PRIORITY JOURNAL; START CODON; VIROGENESIS; VIRUS CAPSID; VIRUS CULTURE; VIRUS GENOME; WILD TYPE;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0036376718     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2002.1444     Document Type: Article

References (36)

1. The UL15 gene of herpes simplex virus 1 contains within its second exon a novel open reading frame that is translated in frame with the UL15 gene product
2. Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC
3. Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC
4. Purification and characterization of herpes simplex virus type 1 alkaline exonuclease expressed in Escherichia coli
5. The product of the UL12.5 gene of herpes simplex virus type 1 is a capsid-associated nuclease
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7. Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells
8. The promoter and transcriptional unit of a novel herpes simplex virus 1 alpha gene are contained in, and encode a protein in frame with, the open reading frame of the alpha 22 gene
9. High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50000-dalton protein tentatively identified as a capsid protein
10. Mutagenesis and characterization of a 41-kilobase-pair region of the pseudorabies virus genome: Transcription map, search for virulence genes, and comparison with homologs of herpes simplex virus type 1
11. Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins
12. Functional conservation of the alkaline nuclease of herpes simplex virus type-1 and human cytomegalovirus
13. The exonuclease activity of HSV-1 UL12 is required for in vivo function
14. In vitro processing of HSV-1 DNA replication intermediates by the viral alkaline nuclease, UL12
15. Structure-function analysis of the herpes simplex virus type 1 UL12 gene: Correlation of deoxyribonuclease activity in vitro with replication function
16. Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system
17. The promoter, transcriptional unit, and coding sequence of herpes simplex virus 1 family 35 proteins are contained within and in frame with the UL26 open reading frame
18. Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates
19. The product of a 1.9-kb mRNA which overlaps the HSV-1 alkaline nuclease gene (UL12) cannot relieve the growth defects of a null mutant
20. Phenotype of the herpes simplex virus type 1 protease substrate ICP35 mutant virus
21. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1
22. Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1
23. DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes
24. Suppression of amber nonsense mutations of herpes simplex virus type 1 in a tissue culture system
25. Temperature-sensitive mutants of herpes simplex virus type 1: Isolation, complementation and partial characterization
26. Study of the structure of replicative intermediates of HSV-1 DNA by pulsed-field gel electrophoresis
27. Branched structures in the intracellular DNA of herpes simplex virus type 1
28. Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus
29. Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA
30. Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein
31. The herpes simplex virus type 1 alkaline nuclease is not essential for viral DNA synthesis: Isolation and characterization of a lacZ insertion mutant
32. Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins
33. Genetic analysis of the UL15 gene locus for the putative terminase of herpes simplex virus type 1
34. Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging