Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates

Journal of Virology

Volumn 70, Issue 4, 1996, Pages 2075-2085

  Martinez, Rik ^a   Sarisky, Robert T ^b,d   Weber, Peter C ^c   Weller, Sandra K ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c PFIZER INC   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEASE; VIRUS DNA;

ANIMAL CELL; ARTICLE; CHROMOSOME INVERSION; DNA REPLICATION; DNA SEQUENCE; DNA SYNTHESIS; GENE INDUCTION; GENE MUTATION; GENETIC RECOMBINATION; HERPES SIMPLEX VIRUS 1; NONHUMAN; PRIORITY JOURNAL; VIRUS CAPSID; VIRUS DNA CELL DNA INTERACTION; VIRUS GENOME;

EID: 0029870883     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.4.2075-2085.1996     Document Type: Article

References (72)

1. Addison, C., F. J. Rixon, and V. G. Preston. 1990. Herpes simplex virus type 1 UL28 gene product is important for the formation of mature capsids. J. Gen. Virol 71:2377-2384.
2. Banks, L., D. J. Purifoy, P. F. Hurst, R. A. Killington, and K. L. Powell. 1983. Herpes simplex virus non-structural proteins. IV. Purification of the virus-induced deoxyribonuclease and characterization of the enzyme using monoclonal antibodies. J. Gen. Virol. 64:2249-2260.
3. Banks, L. M., I. W. Halliburton, D. J. M. Purifoy, R. A. Killington, and K. L. Powell. 1985, Studies on the herpes simplex virus alkaline nuclease: detection of type-common and type-specific epitopes on the enzyme. J Gen. Virol. 66:1-14.
4. Bataille, D., and A. Epstein. 1994. Herpes simplex virus replicative concatemers contain L components in inverted orientation. Virology 203:384-388
5. Becker, Y., Y. Asher, E. Weinberg-Zahlering, S. Rabkin, A. Friedmann, and E. Kessler. 1978. Defective herpes simplex virus DNA: circular and circular-linear molecules resembling rolling circles. J. Gen. Virol. 40:319-335
6. Ben-Porat, T., and F. J. Rixon. 1979. Replication of herpesvirus DNA IV: analysis of concatemers. Virology 94:61-70.
7. Ben-Porat, T., F. J. Rixon, and M. L. Blankenship. 1979. Analysis of the structure of the genome of pseudorabies virus. Virology 95:285-294.
8. Ben-Porat, T., and S. A. Tokazewski. 1977. Replication of herpesvirus DNA. II. Sedimentation characteristics of newly synthesized DNA. Virology 79:292-301.
9. Beverley, S. M. 1988. Characterization of the 'unusual' mobility of large circular DNAs in pulsed field-gradient electrophoresis. Nucleic Acids Res. 16:925-939.
10. Beverley, S. M. 1989. Estimation of circular DNA size using gamma-irradiation and pulsed-field gel electrophoresis. Anal. Biochem. 177:110-114
11. Brown, S. M., J. H. Subak-Sharpe, J. Harland, and A. R. MacLean. 1992. Analysis of intrastrain recombination in herpes simplex virus type 1 strain 17 and herpes simplex virus type 2 strain HG52 using restriction endonuclease sites as unsclected markers and temperature-sensitive lesions as selected markers. J. Gen Virol. 73:293-301.
12. Cairns, J. 1963. The chromosome of Escherichia coli. Cold Spring Harbor Symp. Quant Biol 28:43-46.
13. Costa, R. H., K. G. Draper, L. Banks, K. L. Powell, G. Cohen, R. Eisenberg, and E. K. Wagner. 1983. High-resolution characterization of herpes simplex virus type 1 transcripts encoding alkaline exonuclease and a 50,000-dalton protein tentatively identified as a capsid protein. J. Virol. 48:591-603.
14. deMassy, B., F. W. Studier, L. Dorgai, E. Appelbaum, and R. A. Weisberg. 1984. Enzymes and sites of genetic recombination: studies with gene-3 endonuclease of phage T7 and with site-affinity mutants of phage lambda. Cold Spring Harbor Symp. Quant. Biol. 49:715-726.
15. Draper, K. G., G. Devi-Rao, R. H. Costa, E. D. Blair, R. L. Thompson, and E. K. Wagner. 1986. Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins J. Virol. 57:1023-1036
16. Dutch, R. E., R. C. Bruckner, E. S. Mocarski, and I. R. Lehman. 1992. Herpes simplex virus type 1 recombination: role of DNA replication and viral a sequences. J. Virol. 66:277-285.
17. Enquist, L. W., and A. M. Skalka. 1978. Replication of bacteriophage lambda DNA Trends Biochem. Sci. 3:279-283.
18. Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction fragments to high specific activity. Anal. Biochem. 132:6-13.
19. Futcher, A. B. 1986. Copy number amplification of the 2 micron circle plasmid of Saccharomyces cerevisiae. J. Theor. Biol. 119:197-204.
20. Garber, D. A., S. M. Beverley, and D. M. Coen. 1993 Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis. Virology 197:459-462
21. Gilbert, W., and D. Dressler. 1968 DNA replication: the rolling circle model. Cold Spring Harbor Symp. Quant. Biol. 33:473-484.
22. Goldin, A. L., R. M. Sandri-Goldin, M. Levine, and J. C. Glorioso. 1981. Cloning of herpes simplex virus type 1 sequences representing the whole genome. J. Virol. 38:50-58.
23. Hammerschmidt, W., and J. Mankertz. 1991. Herpes viral DNA replication between the known and unknown Semin Virol. 2:257-269.
24. Hammerschmidt, W., and B. Sugden. 1990. DNA replication of herpesviruses during the lytic phase of their life-cycles. Mol. Biol. Med. 7:45-57.
25. Hayward, G. S., R. J. Jacob, S. C. Wadsworth, and B. Roizman. 1975 Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components. Proc. Natl. Acad. Sci. USA 72:4243-4247.
26. Hirsch, I., G. Cabral, M. Patterson, and N. Biswal. 1977 Studies on intracellular replicating DNA of herpes simplex virus type 1. Virology 81:48-61.
27. Irmiere, A., and W. Gibson. 1983. Isolation and characterization of a noninfectious virion-like particle released from cells infected with human strains of cytomegalovirus. Virology 130:118-133.
28. Irmiere, A., and W. Gibson. 1985 Isolation of human cytomegalovirus intranuclear capsids, characterization of their protein constituents, and demonstration that the B-capsid assembly protein is also abundant in nonintectious enveloped particles. J. Virol 56:277-283
29. Jacob, R. J., L. S. Morse, and B. Roizman. 1979. Anatomy of herpes simplex virus DNA. XII. Accumulation of head to tail concatemers in the nuclei of infected cells and their role in the generation of four isomeric arrangements of viral DNA J Virol. 29:448-457.
30. Jacob, R. J., and B. Roizman. 1977. Anatomy of herpes simplex virus DNA VIII. Properties of the replicating DNA. J. Virol. 23:394-411.
31. Jongeneel, C. V., and S. L. Bachenheimer. 1981. Structure of replicating herpes simplex virus DNA. J. Virol. 39:656-660
32. Kemper, B., F. Jensch, M. von Depka-Prondzynski, H. J. Fritz, U. Borgmeyer, and K. Mizuuchi. 1984. Resolution of Holliday structures by endonuclease VII as observed in interactions with cruciform DNA. Cold Spring Harbor Symp. Quant Biol. 49:815-825.
33. King, G. J., and W. M. Huang. 1982 Identification of the origins of T4 DNA replication. Proc. Natl. Acad. Sci. USA 79:7248-7252.
34. Lee, J. Y., A. Irmiere, and W. Gibson. 1988. Primate cytomegalovirus assembly: evidence that DNA packaging occurs subsequent to B capsid assembly. Virology 167:87-96.
35. Locker, H., and N. Frenkel. 1979. The BamI, KpnI, and SalI restriction enzyme maps of the DNAs of herpes simplex virus strains Justin and F: occurrence of heterogeneities in defined regions of the viral DNA. J. Virol. 32:429-441.
36. Luder, A., and G. Mosig. 1982. Two alternative mechanisms for initiation of DNA replication forks in bacteriophage T4: priming by RNA polymerase and by recombination. Proc. Natl. Acad. Sci. USA 79:1101-1105.
37. Maniatis, T., E. F. Fritsch, and J. Sambrook (ed.). 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
38. 37a.Martin, D. W., and P. C. Weber. Unpublished data.
39. Martinez, R., L. Shao, J. C. Bronstein, P. C. Weber, and S. K. Weller. 1996. The product of a 1 9-kb mRNA which overlaps the HSV-1 alkaline nuclease gene (UL12) cannot relieve the growth defects of a null mutant. Virology 215:152-164
40. 38a.Martinez, R., and S. K. Weller. Unpublished data.
41. McGeoch, D. J., M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor. 1988. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1 J. Gen. Virol. 69:1531-1574.
42. McVoy, M. A., and S. P. Adler. 1994. Human cytomegalovirus DNA replicates after early circularization by concatemer formation, and inversion occurs within the concatemer. J. Virol. 68:1040-1051
43. McVoy, M. M., and S. P. Adler. 1991. Analysis of human cytomegalovirus (HCMV) DNA replicative intermediates: DNA forms not predicted by the rolling circle model, p. 53-56. In M. P. Landini (ed.), Progress in cytomegalovirus research. Elsevier, Amsterdam.
44. Mizuuchi, K., B. Kemper, H. Hays, and R. A. Wiesberg. 1988 T4 endonuclease VII cleaves Holliday structures. Cell 29:357-365.
45. Morgan, A. R., and A. Severini. 1990. Interconversion of replication and recombination structures: implications for terminal repeats and concatemers. J. Theor. Biol. 144:195-202
46. Mosig, G. 1987. The essential role of recombination in phage T4 growth. Annu. Rev. Genet. 21:347-371.
47. Murray, J. A. H., M. Scarpa, N. Rossi, and G. Cesareni. 1987. Antagonistic controls regulate copy number of the yeast 2m plasmid. EMBO J. 6:4205-4212.
48. Nasseri, M., and E. S. Mocarski. 1988 The cleavage recognition signal is contained within sequences surrounding an a-a junction in herpes simplex virus DNA. Virology 167:25-30.
49. O'Callaghan, D. J., M. C. Kemp, and C. C. Randall. 1977. Properties of nucleocapsid species isolated from an in vivo herpesvirus infection J. Gen. Virol. 37:585-594.
50. Panyutin, I. G., and P. Hsieh. 1994. The kinetics of spontaneous DNA branch migration. Proc. Natl. Acad. Sci. USA 91:2021-2025.
51. Petrillo-Peixoto, M. L., and S. M. Beverley. 1988. Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major Mol. Cell. Biol. 8:5188-5199.
52. Sarisky, R. T., and P. C. Weber. 1994. Requirement for double-strand breaks but not for specific DNA sequences in herpes simplex virus type 1 genome isomerization events. J. Virol. 68:34-47.
53. Severini, A., A. R. Morgan, D. R. Tovell, and L. J. Tyrrel. 1994. Study of the structure of replicative intermediates of HSV-1 DNA by pulsed-field gel electrophoresis Virology 200:428-435.
54. Severini, A., D. G. Scraba, and D. L. J. Tyrrel. Branched structures in the replicative intermediates of herpes simplex virus type 1 DNA. Submitted for publication.
55. Shao, L., L. M. Rapp, and S. K. Weller. 1993. Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus. Virology 196:146-162.
56. Sheldrick, P., and N. Berthelot. 1975. Inverted repetitions in the chromosome of herpes simplex virus. Cold Spring Harbor Symp Quant. Biol. 2:667-678.
57. Sherman, G., and S. L. Bachenheimer. 1988 Characterization of intranuclear capsids made by ts morphogenic mutants of HSV-1 Virology 163:471-180
58. Smiley, J. R., J. Duncan, and M. Howes. 1990. Sequence requirements for DNA rearrangements induced by the terminal repeat of herpes simplex virus type 1 KOS DNA. J. Virol. 64:5036-5050.
59. Smiley, J. R., C. Lavery, and M. Howes. 1992. The herpes simplex virus type 1 (HSV-1) a sequence serves as a cleavage/packaging signal but does not drive recombinational genome isomerization when it is inserted into the HSV-2 genome. J. Virol. 66:7505-7510.
60. Som, T., K. A. Armstrong, F. C. Volkert, and J. R. Broach. 1988. Autoregulation of 2 micron circle gene expression provides a model for maintenance of stable plasmid copy levels Cell 52:27-37.
61. Vlazny, D. A., A. Kwong, and N. Frenkel. 1982. Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA. Proc. Natl. Acad. Sci. USA 79:1423-1427
62. Wagner, M. J., and W. C. Summers. 1978 Structure of the joint region and the termini of the DNA of herpes simplex virus type 1. J. Virol. 27:374-384.
63. Weber, P. C., M. D. Challberg, N. J. Nelson, M. Levine, and J. C. Glorioso. 1988. Inversion events in the HSV-1 genome are directly mediated by the viral DNA replication machinery and lack sequence specificity. Cell 54:369-381.
64. Weller, S. K. 1995. Herpes simplex virus DNA replication and genome maturation, p. 189-213. In B S. G. M. Cooper and R. Temin (ed.), Implications of the DNA provirus: Howard Temin's scientific legacy. ASM Press, Washington, D.C.
65. Weller, S. K., E. P. Carmichael, D. P. Aschman, D. J. Goldstein, and P. A. Schaffer. 1987. Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA. Virology 161:198-210.
66. Weller, S. K., K. J. Lee, D. J. Sabourin, and P. A. Schaffer. 1983. Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein J. Virol 45:354-366.
67. Weller, S. K., R. M. Seghatoleslami, L. Shao, D. Rowse, and E. P. Carmichael. 1990. The herpes simplex virus type 1 alkaline nucleate is not essential for viral DNA synthesis: isolation and characterization of a lacZ insertion mutant. J Gen. Virol. 71:2941-2952
68. Weller, S. K., A. Spadaro, J. E. Schaffer, A. W. Murray, A. M. Maxam, and P. A. Schaffer. 1985. Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis. Mol. Cell. Biol. 5:930-942.
69. Wohlrab, F., S. Chatterjee, and R. D. Wells. 1991. The herpes simplex virus 1 segment inversion site is specifically cleaved by a virus-induced nuclear endonuclease. Proc. Natl. Acad. Sci. USA 88:6432-6436.
70. Wohlrab, F., M. J. McLean, and R. D. Wells. 1987. The segment inversion site of herpes simplex virus type 1 adopts a novel DNA structure. J. Biol Chem. 262:6407-6416.
71. Young, C. S. H., G. Cachianes, P. Munz, and S. Silverstein. 1984. Replication and recombination in adenovirus-infected cells are temporally and functionally related J. Virol. 51:571-577.
72. Zhang, X., S. Efstathiou, and A. Simmons. 1994. Identification of novel herpes simplex virus replicative intermediates by field inversion gel electrophoresis: implications for viral DNA amplification strategies. Virology 202:530-539