Verapamil Reverts Resistance to Drug-Induced Apoptosis in Ki-ras-Transformed Cells by Altering the Cell Membrane and the Mitochondrial Transmembrane Potentials

Oncology Research

Volumn 13, Issue 1, 2002, Pages 25-35

  Spalletti Cemia, Daniela ^a   D'Agnano, Igea ^b   Sorrentino, Rosanna ^a   Zupi, Gabriella ^c   Vecchio, Giancarlo ^a   Portella, Giuseppe ^a   Laccetti, Paolo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c Lab Chemioter Sperim Preclinica   (Italy)

Author keywords

Apoptosis; Drug resistance; Membrane potentials; Metastases derived thyroid cells; ras transformation; Verapamil

Indexed keywords

DOXORUBICIN; VERAPAMIL;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG RESISTANCE; HYPERPOLARIZATION; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; METASTASIS; MITOCHONDRIAL MEMBRANE; NONHUMAN; ONCOGENE K RAS; ONCOGENE KI RAS; PHENOTYPE; PRIORITY JOURNAL; RAT; THYROID CELL; ANIMAL; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CELL TRANSFORMATION; EPITHELIUM CELL; INTRACELLULAR MEMBRANE; KINETICS; MITOCHONDRION; ONCOGENE RAS; PATHOLOGY; PHYSIOLOGY; THYROID GLAND;

ANIMALS; APOPTOSIS; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; EPITHELIAL CELLS; GENES, RAS; INTRACELLULAR MEMBRANES; KINETICS; MEMBRANE POTENTIALS; MITOCHONDRIA; RATS; THYROID GLAND; VERAPAMIL;

EID: 0036369643     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504002108747935     Document Type: Article

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